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Cancer Epigenetics for Precision Medicine pp 203–218Cite as

Epigenetic Changes of the Immune System with Role in Tumor Development

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1856))

Abstract

Tumor development is closely related to chronic inflammation and to evasion of immune defense mechanisms by neoplastic cells. The mediators of the inflammatory process as well as proteins involved in immune response or immune response evasion can be subject to various epigenetic changes such as methylation, acetylation, or phosphorylation. Some of these, such as cytokine suppressors, are undergoing repression through epigenetic changes, and others such as cytokines or chemokines are undergoing activation through epigenetic changes, both modifications having as a result tumor progression. The activating changes can affect the receptor molecules involved in immune response and these promote inflammation and subsequently tumor development while the inactivating changes seem to be related to the tumor regression process. The proteins involved in antigen presentation, and, therefore in immune response escape, such as classical HLA proteins and related APM (antigen presentation machinery) with their epigenetic changes contribute to the tumor development process, either to tumor progression or regression, depending on the immune effector cells that are in play.

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Authors and Affiliations

  1. Department of Immunology, University of Medicine and Pharmacy, Iasi, Romania

    Irina Daniela Florea

  2. University of Medicine and Pharmacy, Iasi, Romania

    Christina Karaoulani

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  1. Irina Daniela Florea
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  2. Christina Karaoulani
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  1. Kelly Government Solutions, Bethesda, MD, USA

    Ramona G. Dumitrescu

  2. Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Mukesh Verma

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Florea, I.D., Karaoulani, C. (2018). Epigenetic Changes of the Immune System with Role in Tumor Development. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics for Precision Medicine . Methods in Molecular Biology, vol 1856. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8751-1_11

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  • DOI: https://doi.org/10.1007/978-1-4939-8751-1_11

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