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Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis

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Experimental Models of Cardiovascular Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1816))

Abstract

The Badimon perfusion chamber is an ex vivo model of thrombosis that assesses the thrombogenicity of blood in humans and large animals. It works with native blood thereby excluding any interfering effects of anticoagulants unavoidable with the majority of platelet function testing methodologies. Each variable of the Virchow’s triad (blood, blood flow, and endothelial wall) that modulates blood–vessel wall interaction and thrombus formation is incorporated in this perfusion model. These features make this device a valuable tool for the assessment of thrombogenic potential of various diseases and also gauging the efficacy of antithrombotic (anticoagulant and antiplatelet) treatments.

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References

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Authors and Affiliations

  1. AtheroThrombosis Research Unit, Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    M. Urooj Zafar, Carlos G. Santos-Gallego & Juan J. Badimon

  2. Cardiovascular Research Center, Hospital Santa Cruz and San Pablo, School of Medicine of the Autonomous, University of Barcelona, Barcelona, Spain

    Lina Badimon

Authors
  1. M. Urooj Zafar
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  2. Carlos G. Santos-Gallego
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  3. Lina Badimon
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  4. Juan J. Badimon
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Corresponding author

Correspondence to Juan J. Badimon .

Editor information

Editors and Affiliations

  1. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Kiyotake Ishikawa

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Zafar, M.U., Santos-Gallego, C.G., Badimon, L., Badimon, J.J. (2018). Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 1816. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8597-5_12

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  • DOI: https://doi.org/10.1007/978-1-4939-8597-5_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8596-8

  • Online ISBN: 978-1-4939-8597-5

  • eBook Packages: Springer Protocols

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