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Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease

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Investigations of Early Nutrition Effects on Long-Term Health

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1735))

Abstract

Epidemiologic studies identified the linkage between exposures to stresses, including the type and plane of nutrition in utero with development of disease in later life. Given the critical roles of the placenta in mediating transport of nutrients between the mother and fetus and regulation of maternal metabolism, recent attention has focused on the role of the placenta in mediating the effect of altered nutritional exposures on the development of disease in later life. In this chapter we describe the mechanisms of nutrient transport in the placenta, the influence of placental metabolism on this, and how placental energetics influence placental function in response to a variety of stressors. Further the recent “recognition” that the placenta itself has a sex which affects its function may begin to help elucidate the mechanisms underlying the well-known dimorphism in development of disease in adult life.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA

    Leslie Myatt

  2. Bob and Charlee Moore Institute for Nutrition & Wellness, Oregon Health & Science University, Portland, OR, USA

    Leslie Myatt & Kent L. Thornburg

  3. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA

    Kent L. Thornburg

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  1. Leslie Myatt
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Correspondence to Leslie Myatt .

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  1. Debden, Essex, United Kingdom

    Paul C. Guest

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Myatt, L., Thornburg, K.L. (2018). Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_2

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