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Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

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Book cover c-di-GMP Signaling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1657))

Abstract

Bacteria possess several signaling molecules that regulate distinct phenotypes. Cyclic di-GMP (c-di-GMP) has emerged as a ubiquitous second messenger that regulates bacterial virulence, cell cycle, motility, and biofilm formation. The link between c-di-GMP signaling and biofilm formation affords novel strategies for treatment of biofilm-associated infections, which is a major public health problem. The complex c-di-GMP signaling pathway creates a hurdle in the development of small molecule modulators. Nonetheless, some progress has been made in this regard and inhibitors of c-di-GMP metabolizing enzymes that affect biofilm formation and motility have been documented. Herein we discuss the components of c-di-GMP signaling, their correlation with biofilm formation as well as motility and reported small molecule inhibitors of c-di-GMP signaling.

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Acknowledgment

We acknowledge funding from the NSF: CHE-1307218 and CHE-1636752.

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Authors and Affiliations

  1. Purdue Institute for Drug Discovery, Purdue University, 500 Oval Drive, West Lafayette, IN, 47907, USA

    Clement Opoku-Temeng & Herman O. Sintim

  2. Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA

    Herman O. Sintim

  3. Biochemistry Graduate Program, University of Maryland, College Park, MD, 20742, USA

    Clement Opoku-Temeng

  4. Purdue Institute of Inflammation, Immunology and Infectious Disease, West Lafayette, IN, 47907, USA

    Herman O. Sintim

  5. Department of Chemistry, Center for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA

    Clement Opoku-Temeng

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  1. Clement Opoku-Temeng
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  2. Herman O. Sintim
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Correspondence to Herman O. Sintim .

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Editors and Affiliations

  1. Department of Biological Sciences, Binghamton University Department of Biological Sciences, Binghamton, New York, USA

    Karin Sauer

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Opoku-Temeng, C., Sintim, H.O. (2017). Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules. In: Sauer, K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7240-1_31

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  • DOI: https://doi.org/10.1007/978-1-4939-7240-1_31

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