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HIV Reservoirs in Lymph Nodes and Spleen

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Encyclopedia of AIDS

Definition: The Lymphatic Reservoir

The lymphatic reservoir is constituted by subsets of the CD4+ T lymphocytes, dendritic cells, and cells of monocyte–macrophage lineage which become infected by HIV. After infection, these cells harbor transcriptionally silent but replication-competent HIV DNA, beyond the reach of host immune responses and antiretroviral therapy (ART) (Shan and Siliciano 2013). These cells are generally long-lived and maintain the capacity for viral replication throughout their life spans.

Introduction

After entry into the body, HIV rapidly spreads to regional lymph nodes and other lymphoid tissues. This early exploitation of the lymphatic system is mediated by specific host cells and defines the long-term course of HIV infection (Brenchley et al. 2004; Kramer-Hammerle et al. 2005; Moir et al. 2015). CD4+ T lymphocytes, dendritic cells, and cells from the monocyte–macrophage lineage are principal players in these events, and subsets of these cells become latent...

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Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL, 60611, USA

    Sean G. Kelly

  2. Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL, USA

    Babafemi O. Taiwo

Authors
  1. Sean G. Kelly
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  2. Babafemi O. Taiwo
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Correspondence to Sean G. Kelly .

Editor information

Editors and Affiliations

  1. Department of Cell and Molecular Biology, Northwestern University, Robert H. Lurie Medical Research Center, Chicago, IL, USA

    Thomas J. Hope

  2. VA San Diego Healthcare System and University of California San Diego, La Jolla, CA, USA

    Douglas D. Richman

  3. Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA

    Mario Stevenson

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Kelly, S.G., Taiwo, B.O. (2018). HIV Reservoirs in Lymph Nodes and Spleen. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_431

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  • DOI: https://doi.org/10.1007/978-1-4939-7101-5_431

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7100-8

  • Online ISBN: 978-1-4939-7101-5

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