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Stressed Stability Techniques for Adjuvant Formulations

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Vaccine Adjuvants

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1494))

Abstract

Stressed stability testing is crucial to the understanding of mechanisms of degradation and the effects of external stress factors on adjuvant stability. These studies vastly help the development of stability indicating tests and the selection of stabilizing conditions for long term storage. In this chapter, we provide detailed protocols for the execution of forced degradation experiments that evaluate the robustness of adjuvant formulations against thermal, mechanical, freeze-thawing, and photo stresses.

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Author information

Authors and Affiliations

  1. Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, Toronto, ON, Canada, M2R 3T4

    Manvi Hasija, Anthony Sheung, Nausheen Rahman & Salvador F. Ausar

Authors
  1. Manvi Hasija
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  2. Anthony Sheung
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  3. Nausheen Rahman
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  4. Salvador F. Ausar
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Corresponding author

Correspondence to Salvador F. Ausar .

Editor information

Editors and Affiliations

  1. Infectious Disease Research Institute, Seattle, Washington, USA

    Christopher B. Fox

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© 2017 Springer Science+Business Media New York

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Hasija, M., Sheung, A., Rahman, N., Ausar, S.F. (2017). Stressed Stability Techniques for Adjuvant Formulations. In: Fox, C. (eds) Vaccine Adjuvants. Methods in Molecular Biology, vol 1494. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6445-1_16

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  • DOI: https://doi.org/10.1007/978-1-4939-6445-1_16

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6443-7

  • Online ISBN: 978-1-4939-6445-1

  • eBook Packages: Springer Protocols

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