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Photochemical Models of Focal Brain Ischemia

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Rodent Models of Stroke

Part of the book series: Neuromethods ((NM,volume 120))

Abstract

The photochemical stroke model has a number of advantages: size and location can be exactly determined, the skull does not have to be opened, the model works in rats and mice, and technical variations allow for the induction of subcortical stroke, stroke in newborn animals, or stroke with a penumbra. With photochemical reactions, thrombotic occlusions of large arteries as well as of small penetrating brain arteries may also be produced. However, the model does differ in some aspects from stroke in humans. We herein describe techniques for inducing these stroke models and discuss their potential limitations.

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Authors and Affiliations

  1. Hans Berger Department of Neurology, University Hospital Jena, Erlanger Allee 101, 07747, Jena, Germany

    Anja Urbach & Otto W. Witte

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  1. Anja Urbach
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  2. Otto W. Witte
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Correspondence to Anja Urbach .

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Editors and Affiliations

  1. Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, Germany

    Ulrich Dirnagl

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Urbach, A., Witte, O.W. (2016). Photochemical Models of Focal Brain Ischemia. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 120. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-5620-3_7

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  • DOI: https://doi.org/10.1007/978-1-4939-5620-3_7

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