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Exosomes in Tumor Angiogenesis

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Book cover Tumor Angiogenesis Assays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1464))

Abstract

Exosomes are small vesicles ranging in size between 30 and 150 nm, derived from the luminal membranes of the endosome and are constitutively released by fusion with the cell membrane. Several studies have revealed that exosomes play crucial roles in mediating local and systemic cell communication through the horizontal transfer of information in the form of nucleic material and proteins. This is particularly relevant in the context of the tumor-microenvironment cross talk. Here we describe the method of isolating exosomes and their role in modifying the tumor environment and more specifically in enabling metastasis and promoting angiogenesis.

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Author information

Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Karma Z. Salem, Michele Moschetta, Antonio Sacco, Irene M. Ghobrial, Salomon Manier & Aldo M. Roccaro M.D., Ph.D.

  2. ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy

    Luisa Imberti, Giuseppe Rossi & Aldo M. Roccaro M.D., Ph.D.

Authors
  1. Karma Z. Salem
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  2. Michele Moschetta
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  3. Antonio Sacco
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  4. Luisa Imberti
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  5. Giuseppe Rossi
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  6. Irene M. Ghobrial
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  7. Salomon Manier
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  8. Aldo M. Roccaro M.D., Ph.D.
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Corresponding author

Correspondence to Aldo M. Roccaro M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Neurosciences and Sensory Organs, University of Bari,School of Med Dept of Basic Med Sci, Bari, Italy

    Domenico Ribatti

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© 2016 Springer Science+Business Media New York

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Salem, K.Z. et al. (2016). Exosomes in Tumor Angiogenesis. In: Ribatti, D. (eds) Tumor Angiogenesis Assays. Methods in Molecular Biology, vol 1464. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3999-2_3

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  • DOI: https://doi.org/10.1007/978-1-4939-3999-2_3

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3997-8

  • Online ISBN: 978-1-4939-3999-2

  • eBook Packages: Springer Protocols

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