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Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing

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Injury Models of the Central Nervous System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1462))

Abstract

Recent military combat has heightened awareness to the complexity of blast-related traumatic brain injuries (bTBI). Experiments using animal, cadaver, or biofidelic physical models remain the primary measures to investigate injury biomechanics as well as validate computational simulations, medical diagnostics and therapies, or protection technologies. However, blast injury research has seen a range of irregular and inconsistent experimental methods for simulating blast insults generating results which may be misleading, cannot be cross-correlated between laboratories, or referenced to any standard for exposure. Both the US Army Medical Research and Materiel Command and the National Institutes of Health have noted that there is a lack of standardized preclinical models of TBI. It is recommended that the blast injury research community converge on a consistent set of experimental procedures and reporting of blast test conditions. This chapter describes the blast conditions which can be recreated within a laboratory setting and methodology for testing in vivo models within the appropriate environment.

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Author information

Authors and Affiliations

  1. Biomedical Engineering and Mechanics, Virginia Tech, 447 Kelly Hall, 325 Stanger St., Blacksburg, VA, 24061, USA

    Pamela J. VandeVord Ph.D.

  2. John D Dingell VAMC, Detroit, MI, 48201, USA

    Alessandra Dal Cengio Leonardi

  3. Dyn-FX Consulting Ltd, Amherstburg, ON, Canada

    David Ritzel

Authors
  1. Pamela J. VandeVord Ph.D.
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  2. Alessandra Dal Cengio Leonardi
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  3. David Ritzel
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Corresponding author

Correspondence to Pamela J. VandeVord Ph.D. .

Editor information

Editors and Affiliations

  1. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Firas H. Kobeissy

  2. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA

    C. Edward Dixon

  3. Banyan Biomarkers, Inc. , Alachua, Florida, USA

    Ronald L. Hayes

  4. Banyan Biomarkers, Inc., Alachua, Florida, USA

    Stefania Mondello

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VandeVord, P.J., Leonardi, A.D.C., Ritzel, D. (2016). Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing. In: Kobeissy, F., Dixon, C., Hayes, R., Mondello, S. (eds) Injury Models of the Central Nervous System. Methods in Molecular Biology, vol 1462. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3816-2_7

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  • DOI: https://doi.org/10.1007/978-1-4939-3816-2_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3814-8

  • Online ISBN: 978-1-4939-3816-2

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