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Social Endophenotypes in Mouse Models of Psychiatric Disease

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Animal Models of Behavior Genetics

Part of the book series: Advances in Behavior Genetics ((AIBG))

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Abstract

Psychiatric diseases encompass some of the most complex and debilitating afflictions known to man. Common to several of these diseases, namely autism spectrum disorders (ASDs) and schizophrenia, are impairments in socio-communicative behavior. These impairments have been proposed as candidate endophenotypes of disease processes, being present in prodromal and active stages of disease, as well as in undiagnosed relatives. The genetic bases for these diseases and associated socio-communicative endophenotypes make them highly amenable to study using mouse models. In this review, socio-communicative endophenotypes of two psychiatric diseases—ASDs and schizophrenia—are discussed and translated to measurable behavior in mice. Social interaction and ultrasonic vocalization behavioral paradigms serve as reliable methods for assessing social and communicative functioning in mice, respectively. Several of these paradigms will be overviewed alongside evidence of abnormalities in genetic mouse models of psychiatric disease.

“…the difference in mind between man and the higher animals, great as it is, certainly is one of degree and not of kind. We have seen that the senses and intuitions, the various emotions and faculties, such as love, memory, attention, curiosity, imitation, reason, etc., of which man boasts, may be found in an incipient, or even sometimes in a well-developed condition, in the lower animals.” Charles Darwin, The Descent of Man, page 86 (1871).

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Authors and Affiliations

  1. Graduate Program in Neuroscience, University of Minnesota—Twin Cities, N90 Elliott Hall, 75 East River Parkway, Minneapolis, MN, 55455, USA

    Marc T. Pisansky

  2. Department of Psychology, University of Minnesota—Twin Cities, 75 East River Parkway, Minneapolis, MN, USA

    Irving I. Gottesman & Jonathan C. Gewirtz

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  1. Marc T. Pisansky
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  2. Irving I. Gottesman
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  3. Jonathan C. Gewirtz
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Correspondence to Marc T. Pisansky .

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  1. Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA

    Jonathan C. Gewirtz

  2. Janelia Research Campus, Howard Hughes Medical Institue, Ashburn, Virginia, USA

    Yong-Kyu Kim

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Pisansky, M.T., Gottesman, I.I., Gewirtz, J.C. (2016). Social Endophenotypes in Mouse Models of Psychiatric Disease. In: Gewirtz, J., Kim, YK. (eds) Animal Models of Behavior Genetics. Advances in Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3777-6_8

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