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Secretory Diarrhea

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Ion Channels and Transporters of Epithelia in Health and Disease

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Secretory diarrhea (SD) remains a major cause of morbidity and mortality globally particularly among infants and children. Enterotoxin-mediated diarrhea due to cholera, Escherichia coli (E. coli), and rotavirus remain major causes of SD in developing countries, while genetic diseases that produce defects in intestinal ion transporters and motor proteins are increasingly implicated in diarrheal diseases in developed countries. In recent years, significant advances have been made in understanding various factors that contribute to the underlying pathogenesis of SD. These advances are the result of research progress in the fields of genetics, cell biology, and physiology and animal models that have culminated in the development of new therapeutic agents for treating SD. The major advances in pathophysiology and treatment of enterotoxin and genetic causes of SD in childhood will be reviewed.

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Acknowledgments

The authors wish to acknowledge Anne Collaco for assistance and technical support and the NIH-R01 DK 077065 to NA.

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Authors and Affiliations

  1. Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, LCI-409C, New Haven, CT, 06520, USA

    Nadia Ameen, Md. Kaimul Ahsan & Dmitri V. Kravtsov

  2. Department of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Sascha Kopic

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  1. Nadia Ameen
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  2. Sascha Kopic
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  3. Md. Kaimul Ahsan
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  4. Dmitri V. Kravtsov
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Correspondence to Nadia Ameen .

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  1. Department of Physiology, University of Otago , Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Daniel C Devor

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Ameen, N., Kopic, S., Ahsan, M.K., Kravtsov, D.V. (2016). Secretory Diarrhea. In: Hamilton, K., Devor, D. (eds) Ion Channels and Transporters of Epithelia in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3366-2_29

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