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Dendritic Cells and Type 2 Inflammation

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The Th2 Type Immune Response in Health and Disease

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Abstract

CD4 Th2 lymfocytes producing IL-4, IL-5 and IL-13 are common controllers of type 2 immunity. They respond to allergens and helminthes only when antigen is presented by professional antigen presenting cells like dendritic cells. Dendritic cells express many pattern recognition receptors that can be triggered by type 2 antigens, leading to direct DC activation and Th2 polarization. Alternatively, type 2 stimuli can first trigger barrier epithelial cells that subsequently activate the DCs via release of TSLP, IL-33 and IL-25. It is clear now that also other innate immune cells involved in type 2 immunity such as basophils and ILC2s help DCs to polarize CD4 T cells towards the Th2 direction. In addition to the roles of DCs in priming CD4 Th2 responses, they also control recall responses of memory CD4 Th2 cells to allergens, identifying these cells as important targets for intervention in allergic inflammatory diseases like asthma, dermatitis and rhinitis.

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Authors and Affiliations

  1. Unit Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent University, Technologiepark 927, 9052, Zwijnaarde, Belgium

    Bart N. Lambrecht M.D., Ph.D., Mary van Helden & Hamida Hammad

  2. Department of Respiratory Medicine, Ghent University Hospital, Gent, Belgium

    Bart N. Lambrecht M.D., Ph.D. & Hamida Hammad

  3. Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands

    Bart N. Lambrecht M.D., Ph.D.

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  1. Bart N. Lambrecht M.D., Ph.D.
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  2. Mary van Helden
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  3. Hamida Hammad
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Correspondence to Bart N. Lambrecht M.D., Ph.D. .

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Editors and Affiliations

  1. Rutgers, The State University of New Jer , NEWARK, New Jersey, USA

    William C. Gause

  2. Department of Microbiology and Immunology Belfer Research Building, Michael Kors Professor of Immunology; Director, Jill Roberts Institute for Research in Inflammatory Bowel Disease; Weill Cornell Medical College; Cornell University; Joan and Sanford I. Weill Department of Medicine, New York, New York, USA

    David Artis

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Lambrecht, B.N., van Helden, M., Hammad, H. (2016). Dendritic Cells and Type 2 Inflammation. In: Gause, W., Artis, D. (eds) The Th2 Type Immune Response in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2911-5_3

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