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Sickle Cell Disease

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Atlas of Genetic Diagnosis and Counseling

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Abstract

Sickle cell disease (SCD) is the most common single gene disorder in Afro-Americans, affecting approximately 1 in 375 persons of African ancestry. The frequency of sickle cell trait is about 8% in the US blacks. Sickle blood cells have an increased resistance to malaria. Protection from malaria helps maintain the high prevalence of the sickle gene in areas where malaria is endemic (Fixler and Styles 2002).

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Authors and Affiliations

  1. Medical Genetics, Shriners Hospitals for Children, Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA, USA

    Harold Chen

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Chen, H. (2017). Sickle Cell Disease. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2401-1_215

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  • DOI: https://doi.org/10.1007/978-1-4939-2401-1_215

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