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Retrospective Studies

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Perinatal Programming of Neurodevelopment

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 10))

Abstract

Large retrospective, epidemiological studies accumulated in the late 1980s, providing increasing evidence to the deeply rooted thought that perinatal events could persistently affect the individual’s functioning and health/disease patterns throughout the lifetime. Evidences of such associations can be found in the literature since the beginning of the twentieth century, but studies from Barker, Hales, and colleagues serve as an important hallmark. They proposed the “thrifty phenotype” hypothesis, stating that poor nutrition in fetal and early infant life is detrimental to the development and function of the individuals’ organism, predisposing them to the later development of adult chronic diseases. At first used to explain the increased risk for type 2 diabetes in low birth weight individuals, the hypothesis was soon adapted to other systems, becoming one of the core assumptions of the Developmental Origins of Adult Health and Disease (DOHaD) model.

The central nervous system is also vulnerable to the effects of environmental variation during fetal or neonatal life. Many researchers have explored the effects of perinatal programming on the human neurodevelopment, and some aspects of the brain structure and/or functioning (such as cognitive function, physiological reactivity to stress, and the risk for behavioral disorders or psychopathology) were shown to be modifiable by the exposure to certain adverse events early in life such as neonatal infections, exposure to gestational psychosocial stress, nutrition during gestation, exposure to drugs, or tobacco smoking during pregnancy. Until recently, most studies focused on birth weight as a strong surrogate of the intrauterine environment, investigating the effects of low birth weight (as a marker of suboptimal fetal environment) on a variety of neurodevelopmental outcomes. Despite the fact that literature reviews on this topic are as old as 1940, the more recent retrospective studies are summarized in this chapter.

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  1. Departamento de Pediatria, Faculdade de Medicina—Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, Largo Eduardo Zaccaro Faraco, 90035-903, Porto Alegre, RS, Brazil

    Patrícia Pelufo Silveira MD PhD

  2. Departamento de Psiquiatria, Faculdade de Medicina—Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, Largo Eduardo Zaccaro Faraco, 90035-903, Porto Alegre, RS, Brazil

    Gisele Gus Manfro MD PhD

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Correspondence to Patrícia Pelufo Silveira MD PhD .

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  1. Facultad de Medicina Inst de Biologia Celular y Neurociecias, Universidad de Buenos Aires, Buenos Aires, Argentina

    Marta C. Antonelli

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Silveira, P., Manfro, G. (2015). Retrospective Studies. In: Antonelli, M. (eds) Perinatal Programming of Neurodevelopment. Advances in Neurobiology, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1372-5_12

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