Skip to main content
SpringerLink
Log in

Epstein-Barr Virus Infection and Infectious Mononucleosis

  • Living reference work entry
  • First Online:
Family Medicine

  • 1684 Accesses

Abstract

The Epstein-Barr virus (EBV) is a double-stranded linear DNA virus. Its DNA core is enclosed by an icosahedral nucleocapsid and by a viral envelope. As a member of the Herpesviridae family, EBV is specifically a gamma herpesvirus [1]. There are two subtypes of EBV, EBV-1 and EBV-2, sometimes referred to as EBV types A and B. These are genetically very similar and are not often distinguished from each other in clinical practice [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Similar content being viewed by others

References

  1. Levinson W. Review of medical microbiology and immunology. 9th ed. New York: McGraw Hill Lange; 2006.

    Google Scholar 

  2. Jenson HB. Epstein-Barr virus. Pediatr Rev. 2011;32(9):375–84.

    Article  PubMed  Google Scholar 

  3. Luzuriaga K, Sullivan JL. Infectious mononucleosis. NEJM. 2010;362(21):1993–2000.

    Article  CAS  PubMed  Google Scholar 

  4. Epstein MA, Achong BG, Barr Y. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet. 1964;283(7335):702–3.

    Article  Google Scholar 

  5. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Phys. 2004;70(7):1279–87.

    Google Scholar 

  6. Auwaerter PG. Infectious mononucleosis in middle age. JAMA. 1999;281(5):454–9.

    Article  CAS  PubMed  Google Scholar 

  7. Okano M, Kawa K, Kimura H, Yachie A, Wakiguchi H, Maeda A, Imai S, Ohga S, Kanegane H, Tsuchiya S, Morio T, Mori M, Yokota S, Imashuku S. Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am J Hematol. 2005;80(1):64–9.

    Article  PubMed  Google Scholar 

  8. Aronson MD, Komaroff AL, Pass TM, Ervin CT, Branch WT. Heterophile antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med. 1982;96(4):505–8.

    Article  CAS  PubMed  Google Scholar 

  9. Brigden ML, Au S, Thompson S, Brigden S, Doyle P, Tsaparas Y. Infectious mononucleosis in an outpatient population: diagnostic utility of 2 automated hematology analyzers and the sensitivity and specificity of Hoagland’s criteria in heterophile-positive patients. Arch Path Lab Med. 1999;123(10):875–81.

    CAS  PubMed  Google Scholar 

  10. Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. NEJM. 2004;350(13):1328–37.

    Article  CAS  PubMed  Google Scholar 

  11. Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernan MA, Olek MJ, Hankinson SE, Hunter DJ. Epstein-Barr virus antibodies and risk of multiple sclerosis. JAMA. 2001;286(24):3083–8.

    Article  CAS  PubMed  Google Scholar 

  12. Nielsen TR, Rostgaard K, Nielsen NM, Koch-Henriksen N, Haahr S, Sorensen PS, Hjalgrim H. Multiple sclerosis after infectious mononucleosis. Arch Neur. 2007; 64 (1): 72–5. 2006; 59 (3): 499–503.

    Google Scholar 

  13. Thacker EL, Marzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol. 2006;59(3):499–503.

    Article  PubMed  Google Scholar 

  14. Macsween KF, Higgins CD, McAulay KA, Williams H, Harrison N, Swerdlow AJ, Crawford DH. Infectious mononucleosis in university students in the United Kingdom: evaluation of the clinical features and consequences of the disease. Clin Infect Dis. 2010;50(5):699–706.

    Article  PubMed  Google Scholar 

  15. White PD, Thomas JM, Kangro HO, Bruce-Jones WD, Amess J, Crawford DH, Grover SA, Clare AW. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Lancet. 2001;358(9297):1946–54.

    Article  CAS  PubMed  Google Scholar 

  16. Candy B, Chalder T, Cleare AJ, Wessely S, White PD, Hotopf M. Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review. BJGP. 2002;52(483):844–51.

    PubMed Central  PubMed  Google Scholar 

  17. Torre D, Tambini R. Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand J Infect Dis. 1999;31(6):543–7.

    Article  CAS  PubMed  Google Scholar 

  18. Sasagawa T, Shimakage M, Nakamura M, Sakaike J, Ishikawa H, Inoue M. Epstein-Barr virus (EBV) genes expression in cervical intraepithelial neoplasia and invasive cervical cancer: a comparative study with human papillomavirus (HPV) infection. Hum Pathol. 2000;31(3):318–26.

    Article  CAS  PubMed  Google Scholar 

  19. Putukian A, O’Connor F, Stricker P, McGrew C, Hosey RG, Gordon S, Kinderknecht J, Kriss V, Landry G. Mononucleosis and athletic participation: an evidence-based subject review. Clin J Sport Med. 2008;18(4):309–15.

    Article  PubMed  Google Scholar 

  20. Waninger K, Harcke HT. Determination of safe return to play for athletes recovering from infectious mononucleosis: a review of the literature. Clin J Sport Med. 2005;15(6):410–6.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Primary Care Clinic, Brian Allgood Army Community Hospital, Building 7005, Yongsan Garrison, South Korea

    Alexys J. Hillman

Authors
  1. Alexys J. Hillman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexys J. Hillman .

Editor information

Editors and Affiliations

  1. Department of Family Medicine, University of Nebraska, Omaha, Nebraska, USA

    Paul Paulman

  2. Virginia Beach, Virginia, USA

    Robert Taylor

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland (outside the USA)

About this entry

Cite this entry

Hillman, A.J. (2015). Epstein-Barr Virus Infection and Infectious Mononucleosis. In: Paulman, P., Taylor, R. (eds) Family Medicine. Springer, Cham. https://doi.org/10.1007/978-1-4939-0779-3_40-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-0779-3_40-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Online ISBN: 978-1-4939-0779-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation