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Resting-State Networks

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fMRI: From Nuclear Spins to Brain Functions

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 30))

Abstract

Resting-state networks (RSNs) in fMRI are ‘activation-like’, spatially structured maps of grey matter brain areas exhibiting temporally correlated signal changes, which are believed to reflect neuronal activities of the ‘resting’ brain and which robustly and consistently appear in both resting and task data. They are purported to reflect the intrinsic energy demands of neuron populations that fire together with a common functional purpose. This chapter introduces the concept of RSNs and why they are of interest to neuroscience, describes their characteristics, reviews the methods used for their analysis, and discusses a few areas of application.

The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents. (H.P. Lovecraft, 1890–1937)

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Notes

  1. 1.

    See Cole et al. (2010b) for further details.

References

  • Achard S, Salvador R, Whitcher B, Suckling J, Bullmore E (2006) A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci 26(1):63–72

    Article  CAS  PubMed  Google Scholar 

  • Albert N, Robertson E, Mehta P, Miall R (2009) Resting state networks and memory consolidation. Commun Integr Biol 2(6):530–532

    Article  PubMed Central  PubMed  Google Scholar 

  • Allen G, Barnard H, McColl R, Hester AL, Fields JA, Weiner MF, Ringe WK, Lipton AM, ­Brooker M, McDonald E, Rubin CD, Cullum CM (2007) Reduced hippocampal functional connectivity in alzheimer disease. Arch Neurol 64(10):1482–1487

    Article  PubMed  Google Scholar 

  • Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ (2005a) ­Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry 57(10):1079–1088

    Article  PubMed  Google Scholar 

  • Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ (2005b) ­Antidepressant effect on connectivity of the mood-regulating circuit: an fMRI study. Neuropsycho Pharmacol 30(7):1334–1344.

    CAS  Google Scholar 

  • Anand A, Li Y, Wang Y, Lowe MJ, Dzemidzic M (2009) Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res 171(3):189–198

    Article  PubMed Central  PubMed  Google Scholar 

  • Andrews-Hanna J, Snyder A, Vincent J, Lustig C, Head D, Raichle M, Buckner R (2007) ­Disruption of large-scale brain systems in advanced aging. Neuron 56(5):924–935

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Antrobus J (1968) Information theory and stimulus-independent. Br J Psychol 59:423–430

    Article  Google Scholar 

  • Baker AP, Brookes MJ, Rezek IA, Smith SM, Behrens T, Probert Smith PJ, Woolrich M (2014) Fast transient networks in spontaneous human brain activity. ELife 3:e01867

    Google Scholar 

  • Beckmann C, Smith S (2004) Probabilistic independent component analysis for functional ­magnetic resonance imaging. IEEE Trans Med Imaging 23(2):137–152

    Article  PubMed  Google Scholar 

  • Beckmann CF, Smith SM (2005) Tensorial extensions of independent component analysis for multisubject fMRI analysis. Neuroimage 25(1):294–311

    Article  CAS  PubMed  Google Scholar 

  • Beckmann C, De Luca M, Devlin J, Smith S (2005) Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci 360(1457):1001–1013

    Article  PubMed Central  PubMed  Google Scholar 

  • Beckmann CF, Mackay CE, Filippini N, Smith SM (2009) Group comparison of resting-state fMRI data using multi-subject ICA and dual regression. Neuroimage 47(Supp 1):S148

    Google Scholar 

  • Behrens TEJ, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CAM, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM (2003) Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6(7):750–757

    Article  CAS  PubMed  Google Scholar 

  • Bettus G, Guedj E, Joyeux F, Confort-Gouny S, Soulier E, Laguitton V, Cozzone PJ, Chauvel P, Ranjeva JP, Bartolomei F, Guye M (2009) Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp 30(5):1580–1591

    Article  PubMed  Google Scholar 

  • Bianciardi M, Fukunaga M, van Gelderen P, Horovitz SG, de Zwart JA, Duyn JH (2009a) Modulation of spontaneous fMRI activity in human visual cortex by behavioral state. Neuroimage 45(1):160–168

    Article  PubMed Central  PubMed  Google Scholar 

  • Bianciardi M, Fukunaga M, van Gelderen P, Horovitz SG, de Zwart JA, Shmueli K, Duyn JH (2009b) Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 t study. Magn Reson Imaging 27(8):1019–1029

    Article  PubMed Central  PubMed  Google Scholar 

  • Birn RM, Diamond JB, Smith MA, Bandettini PA (2006) Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI. Neuroimage 31(4):1536–1548

    Article  PubMed  Google Scholar 

  • Birn R, Murphy K, Bandettini P (2008) The effect of respiration variations on independent component analysis results of resting state functional connectivity. Hum Brain Mapp 29(7):740–750

    Article  PubMed Central  PubMed  Google Scholar 

  • Biswal B, Yetkin F, VM H, Hyde J (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537–541

    Article  CAS  PubMed  Google Scholar 

  • Biswal BB, Mennes M, Zuo XN, Gohel S, Kelly C, Smith SM, Beckmann CF, Adelstein JS, Buckner RL, Colcombe S, Dogonowski AM, Ernst M, Fair D, Hampson M, Hoptman MJ, Hyde JS, Kiviniemi VJ, Kötter R, Li SJ, Lin CP, Lowe MJ, Mackay C, Madden DJ, Madsen KH, Margulies DS, Mayberg HS, McMahon K, Monk CS, Mostofsky SH, Nagel BJ, Pekar JJ, Peltier SJ, Petersen SE, Riedl V, Rombouts SARB, Rypma B, Schlaggar BL, Schmidt S, Seidler RD, Siegle GJ, Sorg C, Teng GJ, Veijola J, Villringer A, Walter M, Wang L, Weng XC, WhitfieldGabrieli S, Williamson P, Windischberger C, Zang YF, Zhang HY, Castellanos FX, Milham MP (2010) Toward discovery science of human brain function. Proc Natl Acad Sci U S A 107(10):4734–4739

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bluhm RL, Miller J, Lanius RA, Osuch EA, Boksman K, Neufeld RWJ, The’berge J, Schaefer B, Williamson P (2007) Spontaneous low-frequency fluctuations in the bold signal in schizophrenic patients: anomalies in the default network. Schizophr Bull 33(4):1004–1012

    Article  PubMed Central  PubMed  Google Scholar 

  • Bluhm R, Williamson P, Lanius R, The’berge J, Densmore M, Bartha R, Neufeld R, Osuch E (2009a) Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus. Psychiatry Clin Neurosci 63(6):754–761

    Article  PubMed  Google Scholar 

  • Bluhm RL, Miller J, Lanius RA, Osuch EA, Boksman K, Neufeld RWJ, The’berge J, Schaefer B, Williamson PC (2009b) Retrosplenial cortex connectivity in schizophrenia. Psychiatry Res 174(1):17–23

    Article  PubMed  Google Scholar 

  • Bluhm RL, Williamson PC, Osuch EA, Frewen PA, Stevens TK, Boksman K, Neufeld RWJ, The’berge J, Lanius RA (2009c) Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma. J Psychiatry Neurosci 34(3):187–194

    PubMed Central  PubMed  Google Scholar 

  • Boly M, Phillips C, Tshibanda L, Vanhaudenhuyse A, Schabus M, Dang-Vu TT, Moonen G, Hustinx R, Maquet P, Laureys S (2008) Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Ann N Y Acad Sci 1129:119–129

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Boly M, Tshibanda L, Vanhaudenhuyse A, Noirhomme Q, Schnakers C, Ledoux D, Boveroux P, Garweg C, Lambermont B, Phillips C, Luxen A, Moonen G, Bassetti C, Maquet P, Laureys S (2009) Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum Brain Mapp 30(8):2393–2400

    Article  CAS  PubMed  Google Scholar 

  • Brookes MJ, Woolrich M, Luckhoo H, Price D, Hale JR, Stephenson MC, Barnes GR, Smith SM, Morris PG (2011) Investigating the electrophysiological basis of resting state networks using magnetoencephalography. Proc Natl Acad Sci U S A 108(40):16783–16788

    Google Scholar 

  • Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJS (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33(3):279–296

    Article  PubMed  Google Scholar 

  • Buckner R, Vincent J (2007) Unrest at rest: default activity and spontaneous network correlations. Neuroimage 37(4):1091–1096

    Article  PubMed  Google Scholar 

  • Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain’s default network: anatomy, ­function, and relevance to disease. Ann N Y Acad Sci 1124:1–38

    Article  PubMed  Google Scholar 

  • Calhoun V, Adali T, Pearlson G, Pekar J (2001) A method for making group inferences from ­functional MRI data using independent component analysis. Hum Brain Mapp 14(3):140–151

    Article  CAS  PubMed  Google Scholar 

  • Calhoun VD, Adali T, Pekar JJ (2004a) A method for comparing group fMRI data using independent component analysis: application to visual, motor and visuomotor tasks. Magn Reson Imaging 22(9):1181–1191

    Article  PubMed  Google Scholar 

  • Calhoun VD, Pekar JJ, Pearlson GD (2004b) Alcohol intoxication effects on simulated driving: exploring alcohol-dose effects on brain activation using functional MRI. Neuropsychol Pharmacol 29(11):2097–2017

    Article  CAS  Google Scholar 

  • Cao Q, Zang Y, Sun L, Sui M, Long X, Zou Q, Wang Y (2006) Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance ­imaging study. Neuroreport 17(10):1033–1036

    Article  PubMed  Google Scholar 

  • Castellanos FX, Margulies DS, Kelly C, Uddin LQ, Ghaffari M, Kirsch A, Shaw D, Shehzad Z, Martino AD, Biswal B, Sonuga-Barke EJS, Rotrosen J, Adler LA, Milham MP (2008) Cingulate-precuneus interactions: a new locus of dysfunction in adult attentiondeficit/hyperactivity disorder. Biol Psychiatry 63(3):332–337

    Article  PubMed Central  PubMed  Google Scholar 

  • Cauda F, Micon BM, Sacco K, Duca S, D’Agata F, Geminiani G, Canavero S (2009a) Disrupted intrinsic functional connectivity in the vegetative state. J Neurol Neurosurg Psychiatry 80(4):429–431

    Article  CAS  PubMed  Google Scholar 

  • Cauda F, Sacco K, D’Agata F, Duca S, Cocito D, Geminiani G, Migliorati F, Isoardo G (2009b) Low-frequency bold fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain. BMC Neurosci 10:138

    Article  PubMed Central  PubMed  Google Scholar 

  • Cauda F, Sacco K, Duca S, Cocito D, D’Agata F, Geminiani GC, Canavero S (2009c) Altered resting state in diabetic neuropathic pain. PLoS One 4(2):e4542

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Cauda F, D’Agata F, Sacco K, Duca S, Cocito D, Paolasso I, Isoardo G, Geminiani G (2010) Altered resting state attentional networks in diabetic neuropathic pain. J Neurol Neurosurg Psychiatry 81(7):806–811

    Article  CAS  PubMed  Google Scholar 

  • Chang C, Glover GH (2009) Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Neuroimage 47(4):1448–1459

    Article  PubMed Central  PubMed  Google Scholar 

  • Chang C, Glover GH (2010) Time-frequency dynamics of resting-state brain connectivity ­measured with fMRI. Neuroimage 50(1):81–98

    Article  PubMed Central  PubMed  Google Scholar 

  • Chang C, Liu Z, Chen MC, Liu X, Duyn JH (2013) EEG correlates of time-varying BOLD functional connectivity. Neuroimage 72:227–236

    Google Scholar 

  • Cherkassky VL, Kana RK, Keller TA, Just MA (2006) Functional connectivity in a baseline resting-state network in autism. Neuroreport 17(16):1687–1690

    Article  PubMed  Google Scholar 

  • Christoff K, Gordon A, Smallwood J, Smith R, Schooler J (2009) Experience sampling during fMRI reveals default network and executive system contributions to mind wandering. Proc Natl Acad Sci U S A 106(21):8719

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Church JA, Fair DA, Dosenbach NUF, Cohen AL, Miezin FM, Petersen SE, Schlaggar BL (2009) Control networks in paediatric tourette syndrome show immature and anomalous patterns of functional connectivity. Brain 132(Pt 1):225–238

    Article  PubMed Central  PubMed  Google Scholar 

  • Cole D, Beckmann C, Long C, Matthews P, Durcan M, Beaver J (2010a) Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics. NeuroImage 52(2):590–599

    Article  CAS  PubMed  Google Scholar 

  • Cole D, Smith S, Beckmann C (2010b) Advances and pitfalls in the analysis and interpretation of resting-state fMRI data. Front Syst Neurosci 4:1–15

    Google Scholar 

  • Cordes D, Haughton VM, Arfanakis K, Wendt GJ, Turski PA, Moritz CH, Quigley MA, Meyerand ME (2000) Mapping functionally related regions of brain with functional connectivity mr imaging. AJNR Am J Neuroradiol 21(9):1636–1644

    CAS  PubMed  Google Scholar 

  • Cordes D, Haughton VM, Arfanakis K, Carew JD, Turski PA, Moritz CH, Quigley MA, Meyerand ME (2001) Frequencies contributing to functional connectivity in the cerebral cortex in ­“resting-state” data. AJNR Am J Neuroradiol 22(7):1326–1333

    CAS  PubMed  Google Scholar 

  • Craddock RC, Milham MP, LaConte SM (2013) Predicting intrinsic brain activity. Neuroimage 82:127–136

    Google Scholar 

  • Damoiseaux J, Rombouts S, Barkhof F, Scheltens P, Stam C, Smith S, Beckmann C (2006) ­Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A 103(37):13848–13853

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Damoiseaux J, Beckmann C, Arigita E, Barkhof F, Scheltens P, Stam C, Smith S, Rombouts S (2008) Reduced resting-state brain activity in the “default network” in normal aging. Cereb Cortex 18(8):1856–1864

    Article  CAS  PubMed  Google Scholar 

  • David O, Guillemain I, Saillet S, Reyt S, Deransart C, Segebarth C, Depaulis A (2008) Identifying neural drivers with functional MRI: an electrophysiological validation. PLoS Biol 6(12):e315

    Article  PubMed Central  CAS  Google Scholar 

  • De Luca M, Beckmann CF, De Stefano N, Matthews PM, Smith SM (2006) fMRI resting state networks define distinct modes of long-distance interactions in the human brain. Neuroimage 29(4):1359–1367

    Article  CAS  PubMed  Google Scholar 

  • de Munck JC, Gonc¸alves SI, Huijboom L, Kuijer JPA, Pouwels PJW, Heethaar RM, da Silva FHL (2007) The hemodynamic response of the alpha rhythm: an EEG/fMRI study. Neuroimage 35(3):1142–1151

    Article  CAS  PubMed  Google Scholar 

  • de Pasquale F, Penna SD, Snyder AZ, Lewis C, Mantini D, Marzetti L, Belardinelli P, Ciancetta L, Pizzella V, Romani GL, Corbetta M (2010) Temporal dynamics of spontaneous meg activity in brain networks. Proc Natl Acad Sci U S A 107(13):6040–6045

    Article  PubMed Central  PubMed  Google Scholar 

  • Doria V, Beckmann C, Arichi T, Merchant N, Groppo M, Turkheimer F, Counsell S, Murgasova M, Aljabar P, Nunes R, Larkman D, Rees G, Edwards A (2010) Emergence of resting state networks in the preterm human brain. Proc Natl Acad Sci U S A 107(46):20015–20020

    Google Scholar 

  • Dosenbach NUF, Visscher KM, Palmer ED, Miezin FM, Wenger KK, Kang HC, Burgund ED, Grimes AL, Schlaggar BL, Petersen SE (2006) A core system for the implementation of task sets. Neuron 50(5):799–812

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dosenbach NUF, Fair DA, Miezin FM, Cohen AL, Wenger KK, Dosenbach RAT, Fox MD, Snyder AZ, Vincent JL, Raichle ME, Schlaggar BL, Petersen SE (2007) Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci U S A 104(26):11073–11078

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Esposito F, Scarabino T, Hyvarinen A, Himberg J, Formisano E, Comani S, Tedeschi G, Goebel R, Seifritz E, Salle FD (2005) Independent component analysis of fMRI group studies by ­self-organizing clustering. Neuroimage 25(1):193–205

    Article  PubMed  Google Scholar 

  • Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD (2009) Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety ­disorder. Arch Gen Psychiatry 66(12):1361–1372

    Article  PubMed  Google Scholar 

  • Fair D, Dosenbach N, Church J, Cohen A, Brahmbhatt S, Miezin F, Barch D, Raichle M, Petersen S, Schlaggar B (2007) Development of distinct control networks through segregation and ­integration. Proc Natl Acad Sci U S A 104(33):13507

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fair DA, Cohen AL, Dosenbach NUF, Church JA, Miezin FM, Barch DM, Raichle ME, Petersen SE, Schlaggar BL (2008) The maturing architecture of the brain's default network. Proc Natl Acad Sci U S A 105(10):4028–4032

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Filippini N, MacIntosh B, Hough M, Goodwin G, Frisoni G, Smith S, Matthews P, Beckmann C, Mackay C (2009) Distinct patterns of brain activity in young carriers of the APOE-e4 allele. Proc Natl Acad Sci USA 106:7209–7214

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fox MD, Greicius MD (2010) Clinical applications of resting state functional connectivity. Front Syst Neurosci 4:1–13

    Google Scholar 

  • Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8(9):700–711

    Article  CAS  PubMed  Google Scholar 

  • Fox MD, Snyder AZ, Vincent JL, Corbetta M, Essen DCV, Raichle ME (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A 102(27):9673–9678

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fox MD, Zhang D, Snyder AZ, Raichle ME (2009) The global signal and observed anticorrelated resting state brain networks. J Neurophysiol 101(6):3270–3283

    Article  PubMed Central  PubMed  Google Scholar 

  • Fransson P (2005) Spontaneous low-frequency bold signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp 26(1):15–29

    Google Scholar 

  • Fransson P, Skiöld B, Horsch S, Nordell A, Blennow M, Lagercrantz H, Aden U (2007) Restingstate networks in the infant brain. Proc Natl Acad Sci U S A 104(39):15531–15536

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fransson P, Skiöld B, Engström M, Hallberg B, Mosskin M, Aden U, Lagercrantz H, Blennow M (2009) Spontaneous brain activity in the newborn brain during natural sleep–an fMRI study in infants born at full term. Pediatr Res 66(3):301–305

    Article  PubMed  Google Scholar 

  • Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. Neuroimage 19:1273–1302

    Google Scholar 

  • Friston KJ, Kahan J, Razi A, Stephan KE, Sporns O (2014a) On nodes and modes in resting state fMRI. Neuroimage 99:533–547

    Google Scholar 

  • Friston KJ, Kahan J, Biswal B, Razi A (2014b) A DCM for resting state fMRI. Neuroimage 94:396–407

    Google Scholar 

  • Fukunaga M, Horovitz SG, van Gelderen P, de Zwart JA, Jansma JM, Ikonomidou VN, Chu R, Deckers RHR, Leopold DA, Duyn JH (2006) Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages. Magn Reson Imaging 24(8):979–992

    Article  PubMed  Google Scholar 

  • Gao W, Zhu H, Giovanello KS, Smith JK, Shen D, Gilmore JH, Lin W (2009) Evidence on the emergence of the brain's default network from 2-week-old to 2-year-old healthy pediatric subjects. Proc Natl Acad Sci U S A 106(16):6790–6795

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Glahn D, Winkler A, Kochunov P, Almasy L, Duggirala R, Carless M, Curran J, Olvera R, Laird A, Smith S (2010) Genetic control over the resting brain. Proc Natl Acad Sci U S A 107(3):1223

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Glover GH, Li TQ, Ress D (2000) Image-based method for retrospective correction of physiological motion effects in fMRI: retroicor. Magn Reson Med 44(1):162–167

    Article  CAS  PubMed  Google Scholar 

  • Goebel R, Roebroeck A, Kim D, Formisano E (2003) Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and granger causality mapping. Magn Reson Imaging 21(10):1251–1261

    Article  PubMed  Google Scholar 

  • Goldman RI, Stern JM, Engel J, Cohen MS (2002) Simultaneous EEG and fMRI of the alpha rhythm. Neuroreport 13(18):2487–2492

    Article  PubMed Central  PubMed  Google Scholar 

  • Greicius MD, Menon V (2004) Default-mode activity during a passive sensory task: ­uncoupled from deactivation but impacting activation. J Cogn Neurosci 16(9):1484–1492

    Article  PubMed  Google Scholar 

  • Greicius M, Krasnow B, Reiss A (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 100(1):253–258

    Google Scholar 

  • Greicius MD, Srivastava G, Reiss AL, Menon V (2004) Default-mode network activity ­distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A 101(13):4637–4642

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Greicius M, Flores B, Menon V, Glover G, Solvason H, Kenna H, Reiss A, Schatzberg A (2007) Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry

    Google Scholar 

  • Greicius M, Kiviniemi V, Tervonen O, Vainionpää V, Alahuhta S, Reiss A, Menon V (2008a) ­Persistent default-mode network connectivity during light sedation. Hum Brain Mapp 29(7):839–847

    Article  PubMed Central  PubMed  Google Scholar 

  • Greicius MD, Barad M, Ueno T, Mackey SC (2008b) Chronic pain remodels the brains salience network: a resting-state fMRI study. In: 14th intl meeting of the organization for human brain mapping, Melbourne

    Google Scholar 

  • Griffanti L, Salimi-Khorshidi G, Beckmann CF, Auerbach EJ, Douaud G, Sexton CE, Zsoldos E, Ebmeier KP, Filippini N, Mackay CE, Moeller S, Xu J, Yacoub E, Baselli G, Ugurbil K, Miller KL, Smith SM (2014) ICA-based artefact removal and accelerated fMRI acquisition for improved resting state network imaging. Neuroimage 95:232–247

    Google Scholar 

  • Gusnard DA, Raichle ME (2001) Searching for a baseline: functional imaging and the resting ­human brain. Nat Rev Neurosci 2(10):685–694

    Article  CAS  PubMed  Google Scholar 

  • Harrison BJ, Pujol J, López-Solà M, Hernández-Ribas R, Deus J, Ortiz H, Soriano-Mas C, Yücel M, Pantelis C, Cardoner N (2008a) Consistency and functional specialization in the default mode brain network. Proc Natl Acad Sci U S A 105(28):9781–9786

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Harrison BJ, Pujol J, Ortiz H, Fornito A, Pantelis C, Yücel M (2008b) Modulation of brain resting-state networks by sad mood induction. PLoS One 3(3):e1794

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Hayasaka S, Laurienti PJ (2010) Comparison of characteristics between region-and voxel-based network analyses in resting-state fMRI data. Neuroimage 50(2):499–508

    Article  PubMed Central  PubMed  Google Scholar 

  • He BJ, Snyder AZ, Vincent JL, Epstein A, Shulman GL, Corbetta M (2007) Breakdown of ­functional connectivity in frontoparietal networks underlies behavioral deficits in spatial ­neglect. Neuron 53(6):905–918

    Article  CAS  PubMed  Google Scholar 

  • Hedden T, Dijk KRAV, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL (2009) ­Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci 29(40):12686–12694

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Himberg J, Hyvärinen A, Esposito F (2004) Validating the independent components of neuroimaging time series via clustering and visualization. Neuroimage 22(3):1214–1222

    Article  PubMed  Google Scholar 

  • Hong LE, Gu H, Yang Y, Ross TJ, Salmeron BJ, Buchholz B, Thaker GK, Stein EA (2009) ­Association of nicotine addiction and nicotine’s actions with separate cingulate cortex functional circuits. Arch Gen Psychiatry 66(4):431–441

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Horovitz SG, Fukunaga M, de Zwart JA, van Gelderen P, Fulton SC, Balkin TJ, Duyn JH (2008) Low frequency bold fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Hum Brain Mapp 29(6):671–682

    Article  PubMed  Google Scholar 

  • Horovitz S, Braun A, Carr W (2009) Decoupling of the brain’s default mode network during deep sleep. Proc Natl Acad Sci U S A 106(27):11376–11381

    Google Scholar 

  • Hutchison RM, Womelsdorf T, Allen EA, Bandettini PA, Calhoun VD, Corbetta M, Della Penna S, Duyn JH, Glover GH, Gonzalez-Castillo J, Handwerker DA, Keilholz S, Kiviniemi V, Leopold DA, de Pasquale F, Sporns O, Walter M, Chang C (2013) Dynamic functional connectivity: promise, issues, and interpretation. Neuroimage 80:360–378

    Google Scholar 

  • Jafri M, Pearlson G, Stevens M, Calhoun V (2008) A method for functional network connectivity among spatially independent resting-state components in schizophrenia. Neuroimage 39:1666–1681

    Article  PubMed Central  PubMed  Google Scholar 

  • Jann K, Kottlow M, Dierks T, Boesch C, Koenig T (2010) Topographic electrophysiological ­signatures of fMRI resting state networks. PLoS One 5(9):e12945

    Google Scholar 

  • Johansen-Berg H, Behrens T, Sillery E, Ciccarelli O, Thompson A, Smith S, Matthews P (2005) Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus. Cereb Cortex 15(1):31–39

    Article  PubMed  Google Scholar 

  • Kahan J, Urner M, Moran R, Flandin G, Marreiros A, Mancini L, White M, Thornton J, Yousry T, Zrinzo L, Hariz M, Limousin P, Friston K, Foltynie T (2014) Resting state functional MRI in Parkinson’s disease: the impact of deep brain stimulation on ‘effective’ connectivity. Brain 137(Pt 4):1130–1144

    Google Scholar 

  • Kelly AMC, Uddin LQ, Biswal BB, Castellanos FX, Milham MP (2008) Competition between functional brain networks mediates behavioral variability. Neuroimage 39(1):527–537

    Article  PubMed  Google Scholar 

  • Kelly C, de Zubicaray G, Di Martino A, Copland D, Reiss P, Klein D, Castellanos F, Milham M, McMahon K (2009) L-dopa modulates functional connectivity in striatal cognitive and motor networks: a double-blind placebo-controlled study. J Neurosci 29(22):7364–7378

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kennedy DP, Courchesne E (2008) The intrinsic functional organization of the brain is altered in autism. Neuroimage 39(4):1877–1885

    Article  PubMed  Google Scholar 

  • Kiviniemi V, Kantola JH, Jauhiainen J, Hyvärinen A, Tervonen O (2003) Independent component analysis of nondeterministic fMRI signal sources. Neuroimage 19(2 Pt 1):253–260

    Article  PubMed  Google Scholar 

  • Kiviniemi V, Starck T, Remes J, Long X, Nikkinen J, Haapea M, Veijola J, Moilanen I, Isohanni M, Zang YF, Tervonen O (2009) Functional segmentation of the brain cortex using high model order group pica. Hum Brain Mapp 30(12):3865–3886

    Article  PubMed  Google Scholar 

  • Krüger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46(4):631–637

    Article  PubMed  Google Scholar 

  • Laird AR, Eickhoff SB, Rottschy C, Bzdok D, Ray KL, Fox PT (2013) Networks of tasks coactivation. Neuroimage 80:505–514

    Google Scholar 

  • Laufs H (2008) Endogenous brain oscillations and related networks detected by surface ­EEG-combined fMRI. Hum Brain Mapp 29(7):762–769

    Article  PubMed  Google Scholar 

  • Laufs H, Kleinschmidt A, Beyerle A, Eger E, Salek-Haddadi A, Preibisch C, Krakow K (2003) EEG-correlated fMRI of human alpha activity. Neuroimage 19(4):1463–1476

    Article  CAS  PubMed  Google Scholar 

  • Laufs H, Holt JL, Elfont R, Krams M, Paul JS, Krakow K, Kleinschmidt A (2006) Where the bold signal goes when alpha EEG leaves. Neuroimage 31(4):1408–1418

    Article  CAS  PubMed  Google Scholar 

  • Lewis C, Baldassarre A, Committeri G, Romani G, Corbetta M (2009) Learning sculpts the ­spontaneous activity of the resting human brain. Proc Natl Acad Sci U S A 106(41):17558

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Li SJ, Li Z, Wu G, Zhang MJ, Franczak M, Antuono PG (2002) Alzheimer disease: evaluation of a functional MR imaging index as a marker. Radiology 225(1):253–259

    Article  PubMed  Google Scholar 

  • Liang M, Zhou Y, Jiang T, Liu Z, Tian L, Liu H, Hao Y (2006) Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. Neuroreport 17(2):209–213

    Article  PubMed  Google Scholar 

  • Liu H, Liu Z, Liang M, Hao Y, Tan L, Kuang F, Yi Y, Xu L, Jiang T (2006) Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport 17(1):19–22

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Yu C, Liang M, Li J, Tian L, Zhou Y, Qin W, Li K, Jiang T (2007) Whole brain functional connectivity in the early blind. Brain 130(Pt 8):2085–2096

    Article  PubMed  Google Scholar 

  • Liu Y, Liang M, Zhou Y, He Y, Hao Y, Song M, Yu C, Liu H, Liu Z, Jiang T (2008) Disrupted small-world networks in schizophrenia. Brain 131(Pt 4):945–961

    Article  PubMed  Google Scholar 

  • Lowe MJ, Mock BJ, Sorenson JA (1998) Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations. Neuroimage 7(2):119–132, clinical Trial

    Article  CAS  PubMed  Google Scholar 

  • Lowe MJ, Phillips MD, Lurito JT, Mattson D, Dzemidzic M, Mathews VP (2002) Multiple ­sclerosis: low-frequency temporal blood oxygen level-dependent fluctuations indicate reduced functional connectivity initial results. Radiology 224(1):184–192

    Article  PubMed  Google Scholar 

  • Lu H, Zuo Y, Gu H, Waltz JA, Zhan W, Scholl CA, Rea W, Yang Y, Stein EA (2007) Synchronized delta oscillations correlate with the resting-state functional MRI signal. Proc Natl Acad Sci U S A 104(46):18265–18259

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Luca MD, Smith S, Stefano ND, Federico A, Matthews PM (2005) Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system. Exp Brain Res 167(4):587–594

    Article  PubMed  Google Scholar 

  • Lui S, Ouyang L, Chen Q, Huang X, Tang H, Chen H, Zhou D, Kemp GJ, Gong Q (2008) Differential interictal activity of the precuneus/posterior cingulate cortex revealed by resting state functional MRI at 3t in generalized vs. partial seizure. J Magn Reson Imaging 27(6):1214–1220

    Article  PubMed  Google Scholar 

  • Mantini D, Perrucci MG, Gratta CD, Romani GL, Corbetta M (2007) Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci U S A 104(32):13170–13175

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Martino AD, Ross K, Uddin LQ, Sklar AB, Castellanos FX, Milham MP (2009a) Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis. Biol Psychiatry 65(1):63–74

    Article  PubMed Central  PubMed  Google Scholar 

  • Martino AD, Shehzad Z, Kelly C, Roy AK, Gee DG, Uddin LQ, Gotimer K, Klein DF, Castellanos FX, Milham MP (2009b) Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults. Am J Psychiatry 166(8):891–899

    Article  PubMed Central  PubMed  Google Scholar 

  • Marx E, Deutschländer A, Stephan T, Dieterich M, Wiesmann M, Brandt T (2004) Eyes open and eyes closed as rest conditions: impact on brain activation patterns. Neuroimage 21(4):1818–1824

    Article  PubMed  Google Scholar 

  • Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, Macrae CN (2007) Wandering minds: the default network and stimulus-independent thought. Science 315(5810):393–395

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, Houde O, Crivello F, Joliot M, Petit L, TzourioMazoyer N (2001) Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull 54(3):287–298

    Article  CAS  PubMed  Google Scholar 

  • McKeown MJ, Makeig S, Brown GG, Jung TP, Kindermann SS, Bell AJ, Sejnowski TJ (1998) Analysis of fMRI data by blind separation into independent spatial components. Hum Brain Mapp 6(3):160–188

    Article  CAS  PubMed  Google Scholar 

  • Miller EK, Cohen JD (2001) An integrative theory of prefrontal cortex function. Annu Rev Neurosci 24:167–202

    Article  CAS  PubMed  Google Scholar 

  • Mohammadi B, Kollewe K, Samii A, Krampfl K, Dengler R, Münte TF (2009) Changes of resting state brain networks in amyotrophic lateral sclerosis. Exp Neurol 217(1):147–153

    Article  PubMed  Google Scholar 

  • Monk CS, Peltier SJ, Wiggins JL, Weng SJ, Carrasco M, Risi S, Lord C (2009) Abnormalities of intrinsic functional connectivity in autism spectrum disorders. Neuroimage 47(2):764–772

    Article  PubMed Central  PubMed  Google Scholar 

  • Moosmann M, Ritter P, Krastel I, Brink A, Thees S, Blankenburg F, Taskin B, Obrig H, Villringer A (2003) Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy. Neuroimage 20(1):145–158

    Article  PubMed  Google Scholar 

  • Morcom A, Fletcher P (2007a) Cognitive neuroscience: the case for design rather than default. Neuroimage 37(4):1097–1099

    Article  Google Scholar 

  • Morcom A, Fletcher P (2007b) Does the brain have a baseline? why we should be resisting a rest. Neuroimage 37(4):1073–1082

    Article  Google Scholar 

  • Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA (2009) The impact of global ­signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44(3):893–905

    Article  PubMed Central  PubMed  Google Scholar 

  • Murphy K, Birn RM, Bandettini PA (2013) Resting-state fMRI confounds and cleanup. Neuroimage 80:349–359

    Google Scholar 

  • Niazy RK, Beckmann CF, Smith SM (2006) Investigations into resting state networks temporal characteristics using empirical mode decomposition and ica. In: 12th intl neeting of the organization for human brain mapping, Florence

    Google Scholar 

  • Niazy RK, Smith SM, Beckmann CF (2008) Principal frequency of resting state networks. In: 14th intl meeting of the organization for human brain mapping, Melbourne

    Google Scholar 

  • Obrig H, Neufang M, Wenzel R, Kohl M, Steinbrink J, Einhäupl K, Villringer A (2000) Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults. Neuroimage 12(6):623–639

    Article  CAS  PubMed  Google Scholar 

  • Ogawa S, Tank D, Menon R, Ellermann J, Kim S, Merkle H, Uğurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic ­resonance imaging. Proc Natl Acad Sci U S A 89(13):5951–5955

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Paakki J, Rahko J, Long X, Moilanen I, Tervonen O, Nikkinen J, Starck T, Remes J, Hurtig T, Haapsamo H, Jussila K, Kuusikko-Gauffin S, Mattila ML, Zang Y, Kiviniemi V (2010) Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders. Brain Res 1321:169–179

    Article  CAS  PubMed  Google Scholar 

  • Popa D, Popescu AT, Pare’ D (2009) Contrasting activity profile of two distributed cortical networks as a function of attentional demands. J Neurosci 29(4):1191–201

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Raichle M (2010) Two views of brain function. Trends Cogn Sci 14(4):180–190

    Article  PubMed  Google Scholar 

  • Raichle ME, Gusnard DA (2005) Intrinsic brain activity sets the stage for expression of motivated behavior. J Comp Neurol 493(1):167–176

    Article  PubMed  Google Scholar 

  • Raichle ME, Mintun MA (2006) Brain work and brain imaging. Annu Rev Neurosci 29:449–476

    Article  CAS  PubMed  Google Scholar 

  • Raichle ME, Snyder AZ (2007) A default mode of brain function: a brief history of an evolving idea. Neuroimage 37(4):1083–1090; discussion 1097–1099

    Article  PubMed  Google Scholar 

  • Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL (2001) A default mode of brain function. Proc Natl Acad Sci U S A 98(2):676–682

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ramsey J, Hanson S, Hanson C, Halchenko Y (2010) Six problems for causal inference from fMRI. Neuroimage 49(2):1545–1558

    Google Scholar 

  • Roebroeck A, Formisano E, Goebel R (2005) Mapping directed influence over the brain using granger causality and fMRI. Neuroimage 25(1):230–242

    Google Scholar 

  • Saini S, DeStefano N, Smith S, Guidi L, Amato MP, Federico A, Matthews PM (2004) Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 75(6):840–846

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Salek-Haddadi A, Friston KJ, Lemieux L, Fish DR (2003) Studying spontaneous EEG activity with fMRI. Brain Res Brain Res Rev 43(1):110–133

    Article  CAS  PubMed  Google Scholar 

  • Salimi-Khorshidi G et al (2014) Automatic denoising of functional MRI data: combining independent component analysis and hierarchical fusion of classifiers. Neuroimage 90:449–468

    Google Scholar 

  • Salvador R, Suckling J, Schwarzbauer C, Bullmore E (2005) Undirected graphs of frequencydependent functional connectivity in whole brain networks. Philos Trans R Soc Lond B Biol Sci 360(1457):937–946

    Article  PubMed Central  PubMed  Google Scholar 

  • Salvador R, Mart’ınez A, Pomarol-Clotet E, Sarro’ S, Suckling J, Bullmore E (2007) Frequency based mutual information measures between clusters of brain regions in functional magnetic resonance imaging. Neuroimage 35(1):83–88

    Article  CAS  PubMed  Google Scholar 

  • Schölvinck ML, Maier A, Ye FQ, Duyn JH, Leopold DA (2010) Neural basis of global resting-state fMRI activity. Proc Natl Acad Sci U S A 107(22):10238–10243

    Article  PubMed Central  PubMed  Google Scholar 

  • Seeley WW, Allman JM, Carlin DA, Crawford RK, Macedo MN, Greicius MD, Dearmond SJ, Miller BL (2007a) Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution. Alzheimer Dis Assoc Disord 21(4):S50–S57

    Article  PubMed  Google Scholar 

  • Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD (2007b) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27(9):2349–2356

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Seeley WW, Crawford RK, Miller BL, Greicius MD (2008) Cortical neurodegeneration syndromes target human structural-functional covariance networks. In: 14th intl meeting of the organization for human brain mapping, Melbourne

    Google Scholar 

  • Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD (2009) Neurodegenerative diseases target large-scale human brain networks. Neuron 62(1):42–52

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shehzad Z, Kelly A, Reiss P, Gee D, Gotimer K, Uddin L, Lee S, Margulies D, Roy A, Biswal B, Petkova E, Castellanos F, Milham M (2009) The resting brain: unconstrained yet reliable. Cereb Cortex 19(10):2209–2229

    Article  PubMed Central  PubMed  Google Scholar 

  • Sheline YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S, Mintun MA (2010) Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry 67(6):584–587

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shmuel A, Leopold DA (2008) Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: implications for functional connectivity at rest. Hum Brain Mapp 29(7):751–761

    Article  PubMed  Google Scholar 

  • Shulman G, Corbetta M, Buckner R, Fiez J, Miezin FM, Raichle ME, Petersen SE (1997) Common blood flow changes across visual tasks: I. Increases in subcortical structures and cerebellum but not in nonvisual cortex. J Cogn Neurosci 9(5):624–647

    Article  CAS  PubMed  Google Scholar 

  • Singh KD, Fawcett IP (2008) Transient and linearly graded deactivation of the human default-mode network by a visual detection task. Neuroimage 41(1):100–112

    Article  CAS  PubMed  Google Scholar 

  • Smith SM, Niazy RK, Beckmann CF, Miller K (2008) Resting state networks: neither low frequency nor anti–correlated? In: 14th intl meeting of the organization for human brain mapping, Melbourne

    Google Scholar 

  • Smith S, Fox P, Miller K, Glahn D, Fox P, Mackay C, Filippini N, Watkins K, Toro R, Laird A, Beckmann C (2009) Correspondence of the brain’s functional architecture during activation and rest. Proc Natl Acad Sci U S A 106(31):13040

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Smith S, Miller K, Salimi-Khorshidi G, Webster M, Beckmann C, Nichols T, Ramsey J, Woolrich M (2011) Network modelling methods for fMRI. NeuroImage 59(2):1228–1229

    Google Scholar 

  • Smyser C, Inder T, Shimony J, Hill J, Degnan A, Snyder A, Neil J (2010) Longitudinal analysis of neural network development in preterm infants. Cereb Cortex 20(12):2852–2862

    Google Scholar 

  • Sorg C, Riedl V, Mühlau M, Calhoun VD, Eichele T, Läer L, Drzezga A, Förstl H, Kurz A, Zimmer C, Wohlschläger AM (2007) Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease. Proc Natl Acad Sci U S A 104(47):18760–18765

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sridharan D, Levitin D, Menon V (2008) A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A 105(34):12569–12574

    Google Scholar 

  • Stam CJ, Reijneveld JC (2007) Graph theoretical analysis of complex networks in the brain. Nonlinear Biomed Phys 1(1):3

    Article  PubMed Central  PubMed  Google Scholar 

  • Starck T, Remes J, Nikkinen J, Tervonen O, Kiviniemi V (2010) Correction of low-frequency physiological noise from the resting state bold fMRI–effect on ICA default mode analysis at 1.5 t. J Neurosci Methods 186(2):179–185

    Article  PubMed  Google Scholar 

  • Supekar K, Menon V, Rubin D, Musen M, Greicius MD (2008) Network analysis of intrinsic functional brain connectivity in Alzheimer’s disease. PLoS Comput Biol 4(6):e1000100

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Tian L, Jiang T, Wang Y, Zang Y, He Y, Liang M, Sui M, Cao Q, Hu S, Peng M, Zhuo Y (2006) Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neurosci Lett 400(1–2):39–43

    Article  CAS  PubMed  Google Scholar 

  • Tohka J, Foerde K, Aron A, Tom S, Toga A (2008) Automatic independent component labeling for artifact removal in fMRI. Neuroimage 39(3):1227–1245

    Article  PubMed Central  PubMed  Google Scholar 

  • Uğurbil K et al (2013) Pushing spatial and temporal resolution for functional and diffusion MRI in the human connectome project. Neuroimage 80:80–104

    Google Scholar 

  • Van Dijk KRA, Hedden T, Venkataraman A, Evans KC, Lazar SW, Buckner RL (2010) Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol 103(1):297–321

    Article  PubMed Central  PubMed  Google Scholar 

  • Vanhaudenhuyse A, Noirhomme Q, Tshibanda LJF, Bruno MA, Boveroux P, Schnakers C, Soddu A, Perlbarg V, Ledoux D, Brichant JF, Moonen G, Maquet P, Greicius MD, Laureys S, Boly M (2010) Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133(Pt 1):161–171

    Article  PubMed Central  PubMed  Google Scholar 

  • Vincent JL, Snyder AZ, Fox MD, Shannon BJ, Andrews JR, Raichle ME, Buckner RL (2006) Coherent spontaneous activity identifies a hippocampal-parietal memory network. J Neurophysiol 96(6):3517–3531

    Article  PubMed  Google Scholar 

  • Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Essen DCV, Zempel JM, Snyder LH, Corbetta M, Raichle ME (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447(7140):83–86

    Article  CAS  PubMed  Google Scholar 

  • Waites AB, Briellmann RS, Saling MM, Abbott DF, Jackson GD (2006) Functional connectivity networks are disrupted in left temporal lobe epilepsy. Arch Neurol 59(2):335–343

    Google Scholar 

  • Wang K, Jiang T, Liang M, Wang L, Tian L, Zhang X, Li K, Liu Z (2006a) Discriminative analysis of early Alzheimer’s disease based on two intrinsically anti-correlated networks with resting-state fMRI. Med Image Comput Comput Assist Interv 9(Pt 2):340–347

    PubMed  Google Scholar 

  • Wang L, Zang Y, He Y, Liang M, Zhang X, Tian L, Wu T, Jiang T, Li K (2006b) Changes in hippocampal connectivity in the early stages of Alzheimer’s disease: evidence from resting state fMRI. Neuroimage 31(2):496–504

    Article  PubMed  Google Scholar 

  • Wang K, Liang M, Wang L, Tian L, Zhang X, Li K, Jiang T (2007) Altered functional connectivity in early Alzheimer’s disease: a resting-state fMRI study. Hum Brain Mapp 28(10):967–978

    Article  PubMed  Google Scholar 

  • Wang L, Zhu C, He Y, Zang Y, Cao Q, Zhang H, Zhong Q, Wang Y (2009) Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp 30(2):638–649

    Article  CAS  PubMed  Google Scholar 

  • Weng S, Wiggins J, Peltier S, Carrasco M, Risi S, Lord C, Monk C (2010) Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders. Brain Res 1313:202–214

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Whitfield-Gabrieli S, Thermenos HW, Milanovic S, Tsuang MT, Faraone SV, McCarley RW, Shenton ME, Green AI, Nieto-Castanon A, LaViolette P, Wojcik J, Gabrieli JDE, Seidman LJ (2009) Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A 106(4):1279–1284

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wink AM, Bullmore E, Barnes A, Bernard F, Suckling J (2008) Monofractal and multifractal dynamics of low frequency endogenous brain oscillations in functional MRI. Hum Brain Mapp 29(7):791–801

    Article  PubMed  Google Scholar 

  • Wise RG, Ide K, Poulin MJ, Tracey I (2004) Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. Neuroimage 21(4):1652–1664

    Article  PubMed  Google Scholar 

  • Woolrich MW, Stephan KE (2013) Biophysical network models and the human connectome. Neuroimage 80:330–338

    Google Scholar 

  • Xiong J, Parsons LM, Gao JH, Fox PT (1999) Interregional connectivity to primary motor cortex revealed using MRI resting state images. Hum Brain Mapp 8(2–3):151–156

    Article  CAS  PubMed  Google Scholar 

  • Yu C, Liu Y, Li J, Zhou Y, Wang K, Tian L, Qin W, Jiang T, Li K (2008) Altered functional connectivity of primary visual cortex in early blindness. Hum Brain Mapp 29(5):533–543

    Article  PubMed  Google Scholar 

  • Zang Y, Jiang T, Lu Y, He Y, Tian L (2004) Regional homogeneity approach to fMRI data analysis. Neuroimage 22(1):394–400

    Article  PubMed  Google Scholar 

  • Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, Tian LX, Jiang TZ, Wang YF (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 29(2):83–91

    Article  PubMed  Google Scholar 

  • Zhang Z, Lu G, Zhong Y, Tan Q, Liao W, Chen Z, Shi J, Liu Y (2009a) Impaired perceptual networks in temporal lobe epilepsy revealed by resting fMRI. J Neurol 256(10):1705–1713

    Article  PubMed  Google Scholar 

  • Zhang Z, Lu G, Zhong Y, Tan Q, Yang Z, Liao W, Chen Z, Shi J, Liu Y (2009b) Impaired attention network in temporal lobe epilepsy: a resting fMRI study. Neurosci Lett 458(3):97–101

    Article  CAS  PubMed  Google Scholar 

  • Zhou Y, Liang M, Jiang T, Tian L, Liu Y, Liu Z, Liu H, Kuang F (2007) Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neurosci Lett 417(3):297–302

    Article  CAS  PubMed  Google Scholar 

  • Zhu CZ, Zang YF, Liang M, Tian LX, He Y, Li XB, Sui MQ, Wang YF, Jiang TZ (2005) Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder. Med Image Comput Comput Assist Interv 8(Pt 2):468–475

    CAS  PubMed  Google Scholar 

  • Zhu C, Zang Y, Cao Q, Yan C, He Y, Jiang T, Sui M, Wang Y (2008) Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage 40(1):110–120

    Article  PubMed  Google Scholar 

  • Zou QH, Zhu CZ, Yang Y, Zuo XN, Long XY, Cao QJ, Wang YF, Zang YF (2008) An improved approach to detection of amplitude of low-frequency fluctuation (alff) for resting-state fMRI: fractional ALFF. J Neurosci Methods 172(1):137–141

    Article  PubMed Central  PubMed  Google Scholar 

  • Zuo XN, Kelly C, Adelstein JS, Klein DF, Castellanos FX, Milham MP (2010a) Reliable intrinsic connectivity networks: test-retest evaluation using ICA and dual regression approach. Neuroimage 49(3):2163–2177

    Article  PubMed Central  PubMed  Google Scholar 

  • Zuo XN, Martino AD, Kelly C, Shehzad ZE, Gee DG, Klein DF, Castellanos FX, Biswal BB, Milham MP (2010b) The oscillating brain: complex and reliable. Neuroimage 49(2):1432–1445

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Biomedical Physics Department, King Faisal Specialist Hospital & Research Centre, MBC 03, P.O. Box 3354, 11211, Riyadh, Saudi Arabia

    Rami K. Niazy

  2. Centre for Neuroscience, Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK

    David M. Cole

  3. Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging (DCCN), Radboud University Nijmegen, Nijmegen, The Netherlands

    Christian F. Beckmann

  4. MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands

    Christian F. Beckmann

  5. Oxford University Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, OX3 9DU, Oxford, UK

    Stephen M. Smith

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  1. Rami K. Niazy
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Correspondence to Rami K. Niazy .

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  1. Maastricht Brain Imaging Centre, Maastricht University, Maastricht, The Netherlands

    Kamil Uludag

  2. University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Kamil Ugurbil

  3. Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado, USA

    Lawrence Berliner

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Niazy, R., Cole, D., Beckmann, C., Smith, S. (2015). Resting-State Networks. In: Uludag, K., Ugurbil, K., Berliner, L. (eds) fMRI: From Nuclear Spins to Brain Functions. Biological Magnetic Resonance, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7591-1_14

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