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Axoplasmic Transport

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Handbook of Neurochemistry

Abstract

When an axon is severed, the portion separated from the perikaryon degenerates and there is progressive regeneration from the perikaryal stump. This observation is the basis for the concept that the viability of the axon is dependent upon transport of materials from the nerve cell body. It illustrates not only that the axon cannot survive without perikaryal materials but also that the nerve cell body, even in adulthood, has the capacity to synthesize and transport all these critical constituents. In the past few years there has been increasing study of the details of axoplasmic transport. Although it would appear that a major function of this process is the replacement of axonal materials that have been degraded or secreted, increasing attention is being directed to the possibility that materials are transported selectively for regulation of aspects of axonal or nerve ending function. The possibility that important biosynthetic processes can occur in the axon and nerve ending independent of the perikaryon also is being investigated.

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Authors and Affiliations

  1. Departments of Psychiatry and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

    Samuel H. Barondes

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  1. Samuel H. Barondes
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Editors and Affiliations

  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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© 1969 Springer Science+Business Media New York

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Barondes, S.H. (1969). Axoplasmic Transport. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7321-4_18

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  • DOI: https://doi.org/10.1007/978-1-4899-7321-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7301-6

  • Online ISBN: 978-1-4899-7321-4

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