Abstract
The diuretic effect of spironolactone is due to its action as an aldosterone antagonist. Hydrochlorothiazide promotes the excretion of sodium and water mainly by inhibiting their reabsorption in the cortical diluting segment of the renal tubule. Aldactazide lowers systolic and diastolic blood pressure in many patients with hypertension even when aldosterone secretion is within normal limits.
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Literature
Medical Letter 23:45, 1981.
Seller, RH. et al: Arch Intern Med 113:350, 1964.
Winer, BM, et al: JAMA 204:775, 1968.
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© 1982 Springer-Verlag Berlin Heidelberg
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Tallarida, R.J. (1982). Aldactazide® (Searle). In: TOP 200. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6746-6_4
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DOI: https://doi.org/10.1007/978-1-4899-6746-6_4
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