Abstract
Over the past ten years, tremendous advances have been made in the basic understanding of the biological substratum of mental processes. This has been reflected by increased understanding of the metabolism of neurohormones, the genetics of mental illness, the structure activity relationship of hallucinogens and the possible mechanism of action of psychopharmacological agents. Stemming from this new understanding have been a number of new techniques for the study of biochemical processes, and as a result of these techniques, several investigations of biochemical abnormalities related to schizophrenia have been undertaken which were not previously possible. All of these advances have given great forward momentum to the field of biological psychiatry, and it should be necessary to detail only a few to demonstrate this point.
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References
Bergen, J.R., Possible relationship of a plasma factor to schizophrenia, Trans. N.Y. Acad. Sci., 28, 40–46, 1965.
Bourdillon, R. E. and Ridges, A. P., 3,4-Dimethoxyphenylethylamine in schizophrenia? In: Amines and Schizophrenia, Himwich, Kety and Smvthies (Eds.), Pergamon Press, Oxford, 1967.
Creveling, C. R. and Daly, J. W., Identification of 3,4-dimethoxyphenylethylamine from schizophrenic urine by mass spectrometry, Nature, 216, 190–191, 1967.
Faurbye, A. and Pind, K., Investigation on the occurrence of the dopamine metabolite, 3,4-dimethoxyphenylethylamine, Acta Psychiat. Scand., 40, 240–243, 1964.
Friedhoff, A. J., Metabolism of dimethoxyphenethylamine and its possible relationship to schizophrenia. In: Origins of Schizophrenia, Romano (Ed.), Excerpta Medica Internat’l Cong. Ser., 151, 27–34, 1968.
Friedhoff, A. J. and Furiya, K., 3,4-Dimethoxyphenylacetic acid in urine, Nature, 214, 1127–1128, 1967.
Friedhoff, A. J. and Van Winkle, E., Isolation of a compound from the urine of schizophrenics, Nature, 194, 897–898, 1962 a.
Friedhoff, A. J. and Van Winkle, E., New Developments in the investigation of the relationship of 3,4-dimethoxyphenethylamine to schizophrenia. In: Amines and Schizophrenia, Himwich, Kety & Smythies (Eds.), Pergamon Press, Oxford, 1966.
Friedhoff, A. J. and Van Winkle, E., The characteristics of an amine found in the urine of schizophrenic patients, J. Nerv. Ment. Dis., 135, 550–555, 1962 b.
Kuehl, F. A., Ormond, R. E. and Vandenheuvel, W. J. A., Occurrence of 3,4-dimethoxyphenylacetic acid in the urines of normal and schizophrenic individuals, Nature, 211, 606, 1966.
Nordio, S., Berio, A. and Distefano, A., Pink spot and other amines in urine, Lancet, 2, 311–312, 1967.
Perry, T. L., Hansen, S. and Macintyre, L., Failure to detect 3,4-dimethoxyphenylethylamine in the urine of schizophrenics, Nature, 202, 519–520, 1964.
Predescu, V., Florescu, D. and Radulescu, C., Pink spot as a diagnostic test in schizophrenia, Nature, 217, 1150–1151, 1968.
Proctor, C. D., Cho, J. B., Ashley, L. G., Potts, J. L., Eaton, H. E., McGriff, J. E., Douglas, J. G. and Amoroso, C. P., Factors influencing a blood plasma-DMPEA test for schizophrenia, Fedn. Proc., 27, 219, 1968.
Ridges, A. P. and Bourdillon, R. E., Schizophrenia, transmethylation and pink spot, Proc. Royal Soc. Med., 60, 555–560, 1966.
Sen, N. P. and McGeer, P. L., 4-Methoxyphenylethylamine and 3,4-dimethoxyphenylethylamine in human urine, Biochem. Biophys. Res. Commun., 14, 227, 1964.
Takesada, M., Kakimoto, Y., Sano, I. and Kaneko, Z., 3,4-Dimethoxyphenylethylamine and other amines in the urine of schizophrenic patients, Nature, 199, 203–204, 1963.
Vacca, L., Fujimori, M., Davis, S. H. and Marrazzi, A., Cerebral synaptic transmission and behavioral effects of dimethoxyphenylethylamine: A potential psychotogen, Science, 160, 95–96, 1968.
Vogel, W. H., Ahlberg, C. D. and Horwitt, M. K., Time study of the urinary excretion of 3,4-dimethoxyphenylethylamine and 3,4-dimethoxyphenylacetic acid by schizophrenic and normal individuals, Internat. J. Psychiat., 3, 292–297, 1967.
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Friedhoff, A.J. (1969). Present Directions in the Investigation of Dimethoxyphenethylamine. In: Bogoch, S. (eds) The Future of the Brain Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6323-9_54
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DOI: https://doi.org/10.1007/978-1-4899-6323-9_54
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