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Hypothyroidism

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Thyroid Disease in Clinical Practice

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Abstract

Hypothyroidism is present when there is insufficient action of thyroid hormones to meet the requirements of the body. The vast majority of patients suffering from hypothyroidism have disease of the thyroid: primary hypothyroidism. Lesser numbers have disease of the pituitary or hypothalamus, which are called secondary and tertiary hypothyroidism respectively. These are also called central hypothyroidism. Exceptionally rare causes of hypothyroidism (quaternary hypothyroidism) are peripheral resistance to thyroid hormone [1], and inactivation of circulating hormones by specific autoantibodies [2, 3]. The severity of hypothyroidism varies from cases which are so mild that diagnosis is based on biochemical findings, to those which are life threatening and easily diagnosed clinically [4], Severe hypothyroidism with skin changes is called myxoedema.

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  1. Stanford University School of Medicine, California, USA

    I. Ross McDougall MB, CHB, PhD, FACP, FRCP (Glas) (Professor of Radiology and Medicine)

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McDougall, I.R. (1992). Hypothyroidism. In: Thyroid Disease in Clinical Practice. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2881-8_6

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