Abstract
Enormous advances have been made during the past three decades in the development of organic chemicals as insect control agents. During this period, beginning approximately after the discovery of the insecticidal properties of DDT, countless numbers of new compounds of widely varying structures have been synthesized and evaluated for insecticidal activity. For the large part, the approaches taken to discover new insecticides have been empirical, i.e., through systematic analogue synthesis and screening. While such an approach has resulted in the unveiling of many useful compounds for insect control, it has been less than satisfying to individuals having the propensity to rationalize biological activity in terms of fundamental chemical and biochemical concepts. This is not meant to minimize the value of the empirical approach, for without it the establishment of meaningful relationships between chemical structure and biological activity would not be possible.
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Fukuto, T.R. (1976). Physicochemical Aspects of Insecticidal Action. In: Wilkinson, C.F. (eds) Insecticide Biochemistry and Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2212-0_11
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