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Overview of Biomedical Issues in Autism

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Neurobiological Issues in Autism

Part of the book series: Current Issues in Autism ((CIAM))

Abstract

It has become a tradition, in papers attempting an overview or integrative analysis of issues in autism, to start out with a few protective remarks concerning the extreme difficulty of the task, and the problems of the current state of affairs that prevent a successful effort. The authors are then set free to roam and forage as they will, relatively protected from criticism. We shall not deviate from such a formidable and effective tradition. It is one of the advantages of a maintenance of sameness (which has a better adaptive connotation than the corollary resistance to change, which implies rigidity; Ciaranello, Vandenberg, & Anders, 1982).

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References

  • Albert, D. J., & Chew, G. L. (1980). The septal forebrain and the inhibitory modulation in attack and defense in the rat: A review. Behavioral Neurology and Biology, 30, 357–388.

    Article  CAS  Google Scholar 

  • Arbib, M. A. (1972). The metaphorical brain. New York: Wiley.

    Google Scholar 

  • Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35, 866–874.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, D. C., Blanchard, R. J., Lee, E. M. C., & Fukunaga, K. K. (1977). Movement arrest and the hippocampus. Physiological Psychology, 5, 331–335.

    Google Scholar 

  • Blanchard, D. C., Williams, G., Lee, E. M. C., & Blanchard, R. J. (1981a). Taming in the wild Norway rat following lesions in the basal ganglia. Physiology and Behavior, 27, 995–1000.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard, D. C., Williams, G., Lee, E. M. C., & Blanchard, R. J. (1981b). Taming of wild rattus Norvegicus by lesions of the mesencephalic central gray. Physiological Psychology, 9, 157–163.

    Google Scholar 

  • Boesen, V., & Aarkrog, T. (1967). Pneumoencephalography of patients in a child psychiatric department. Danish Medical Bulletin, 14, 210–218.

    PubMed  CAS  Google Scholar 

  • Broadhurst, P. L. (1978). Drugs and the inheritance of behavior: A survey of comparative psycho-pharmacogenetics. New York: Plenum Press.

    Book  Google Scholar 

  • Campbell, M., Rosebloom, S., Perry, R., George, A. E., Richeff, I. T., Anderson, L., Small, A. A., & Jennings, S. J. (1982). Computerized oxial tomography in young autistic children. American Journal of Psychiatry, 139, 510–512.

    PubMed  CAS  Google Scholar 

  • Caparulo, B. K., Cohen, D. J., Rothman, S. L., Young, J. G., Katz, J. D., Shaywitz, S. E., & Shaywitz, B. A. (1981). Computed tomographic brain scanning in children with developmental neuropsychiatric disorders. Journal of the American Academy of Child Psychiatry, 20, 338–357.

    Article  PubMed  CAS  Google Scholar 

  • Capute, A. J., Derivan, A. T., Chauvel, P. J., & Rodriguez, A. (1975). Infantile autism: I. A prospective study of the diagnosis. Developmental Medicine and Child Neurology, 17, 58–62.

    Article  PubMed  CAS  Google Scholar 

  • Chess, S. (1977). Follow-up report on autism in congenital rubella. Journal of Autism and Childhood Schizophrenia, 7, 68–81.

    Article  Google Scholar 

  • Chozick, B. S. (1983). The behavioral effects of lesions of the corpus striatum: A review. International Journal of Neuroscience, 19, 143–160.

    Article  PubMed  CAS  Google Scholar 

  • Ciaranello, R. D., Vandenberg, S. R., & Anders, T. F. (1982). Intrinsic and extrinsic determinants of neural development: Relation to infantile autism. Journal of Autism and Developmental Disorders, 12, 115–145.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, D. J., Caparulo, B. K., Shaywitz, B. A., & Bowers, M. B. (1977). Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. Archives of General Psychiatry, 34, 545–550.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, D. J., Young, J. G., & Roth, J. A. (1977). Platelet monoamine oxidase in early childhood autism. Archives of General Psychiatry, 34, 534–537.

    Article  PubMed  CAS  Google Scholar 

  • Coleman, M. (1979). Studies of the autistic syndromes. In R. Katzman (Ed.), Congenital and acquired cognitive disorders. Research Publications, Association for Research in Nervous and Mental Disease, 57, 265–275.

    Google Scholar 

  • Corbett, J., Harris, R., Taylor, R., & Trimble, M. (1977). Progressive distintegrative psychoses of childhood. Journal of Child Psychology and Psychiatry, 18, 211–219.

    Article  PubMed  CAS  Google Scholar 

  • Crosby, E. C., Humphrey, T., & Lauer, W. (1962). Correlative neuroanatomy of the nervous system. New York: Macmillan.

    Google Scholar 

  • Dalby, M. (1975). Air studies of speech-retarded children: Evidence of early lateralization of language function. Abstract, First International Congress of Child Neurology, Toronto.

    Google Scholar 

  • Damasio, A. R., & Maurer, R. G. (1978). A neurological model for childhood autism. Archives of Neurology, 35, 777–786.

    Article  PubMed  CAS  Google Scholar 

  • Damasio, H., Maurer, R. G., Damasio, A. R., & Chui, H. C. (1980). Computerized tomographic scan findings in patients with autistic behavior. Archives of Neurology, 37, 504–510.

    Article  PubMed  CAS  Google Scholar 

  • DeLong, G. R. (1978). A neuropsychologic interpretation of infantile autism. In M. Rutter & E. Schopler (Eds.), A reappraisal of concepts and treatment. New York: Plenum Press.

    Google Scholar 

  • DeMyer, M. K. (1979). Parents and children in autism. Washington, D.C.: V. H. Winston.

    Google Scholar 

  • DeMyer, M. K., Bryson, C. Q., & Churchill, D. W. (1973). The earliest indicators of pathological development: Comparison of symptoms during infancy and early childhood in normal, subnormal, schizophrenic and autistic children. In Biological and environmental determinants of early development. Research Publications, Association for Research in Nervous and Mental Disease, 51, 298–332.

    Google Scholar 

  • DeMyer, M. K., Hingtgen, J. N., & Jackson, R. K. (1981). Infantile autism reviewed: A decade of research. Schizophrenia Bulletin, 7(3), 388–451.

    Article  PubMed  CAS  Google Scholar 

  • Fish, B., & Ritvo, E. R. (1978). Psychoses of childhood. In J. D. Noshpitz & I. Berlin (Eds.), Basic handbook of child psychiatry. New York: Basic Books.

    Google Scholar 

  • Fish, B., & Ritvo, E. R. (1979). Psychoses of childhood. In J. D. Noshpitz (Ed.), Basic handbook of child psychiatry (Vol. 2). Disturbances in development (pp. 249–304). New York: Basic Books.

    Google Scholar 

  • Folstein, S., & Rutter, M. (1977). Genetic influences and infantile autism. Nature, 265, 726–728.

    Article  PubMed  CAS  Google Scholar 

  • Folstein, S., & Rutter, M. (1978). A twin study of individuals with infantile autism. In M. Rutter & E. Schopler (Eds.), A reappraisal of concepts and treatment. New York: Plenum Press.

    Google Scholar 

  • Freeman, B. J., Ritvo, E., Guthrie, D., Schroth, P., & Ball, J. (1978). The behavior observation scale for autism. Initial methodology, data analysis, and preliminary findings on 89 children. Journal of the American Academy of Child Psychiatry, 17, 576–588.

    Article  PubMed  CAS  Google Scholar 

  • Fuster, J. M. (1980). The prefrontal cortex: Anatomy, physiology, and neuropsychology of the frontal lobe. New York: Raven Press.

    Google Scholar 

  • Goldman-Rakic, P. S., Isseroff, A., Schwartz, M. L., & Bugbee, N. M. (1983). The neurobiology of cognitive development. In P. H. Mussen (Ed.), M. M. Haith & J. J. Campos (Vol. Eds.), Handbook of child psychology (Vol. 2). New York: Wiley.

    Google Scholar 

  • Gottlieb, G. (1983). The psychobiological approach to developmental issues. In P. H. Mussen (Eds.), M. M. Haith & J. J. Campos (Vol. Ed.), Handbook of child psychology (Vol. 2). New York: Wiley.

    Google Scholar 

  • Harlow, H. F., & Harlow, M. K. (1965). The affectional systems. In A. M. Schrier, H. F. Harlow, & F. Stollnitz (Eds.), Behavior of nonhuman primates (Vol. 2). New York: Academic Press.

    Google Scholar 

  • Hasobuchi, Y., Adams, J. E., & Linchitz, R. (1977). Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science, 197, 183–186.

    Article  Google Scholar 

  • Hauser, S. L., DeLong, G. R., & Rosman, N. P. (1975). Pneumographic findings in the infantile autism syndrome: A correlation with temporal lobe disease. Brain, 98, 667–668.

    Article  PubMed  CAS  Google Scholar 

  • Heir, D. E., LeMay, M., & Rosenberger, P. B. (1978). Autism: Association with reversed cerebral asymmetry. Neurology, 28, 348–349.

    Google Scholar 

  • Hingtgen, J. N., & Bryson, C. Q. (1972). Recent developments in the study of early childhood psychoses: Infantile autism, childhood schizophrenia, and related disorders. Schizophrenia Bulletin, 5, 8–54.

    Article  Google Scholar 

  • Hole, K., Fuxe, K., & Jonsson, G. (1976). Behavioral effects of 5,7-dihydroxy tryptamine lesions of ascending 5-hydroxytryptamine pathways. Brain Research, 107, 385–389.

    Article  PubMed  CAS  Google Scholar 

  • Holson, R., & Sackett, G. P. (1984). Effects of isolation rearing on learning by mammals. Psychology of Learning and Motivation, 18.

    Google Scholar 

  • Isaacson, R. (1974). The limbic system. New York: Plenum Press.

    Book  Google Scholar 

  • Iversen, S. D. (1977). Brain dopamine systems and behavior. In L. L. Iversen, S. D. Iversen, & S. H. Snyder (Eds.), Handbook of psychopharmacology (Vol. 8, pp. 333–384). New York: Plenum Press.

    Chapter  Google Scholar 

  • Johnston, M. V., & Singer, H. S. (1982). Brain neurotransmitters and neuromodulators in pediatrics. Pediatrics, 70, 57–68.

    PubMed  CAS  Google Scholar 

  • Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.

    Google Scholar 

  • Knobloch, H., & Pasamanick, B. (1975). Some etiologic and prognostic factors in early infantile autism and psychosis. Pediatrics, 55, 182–191.

    PubMed  CAS  Google Scholar 

  • Lieblich, I. (1982). Implication of the use of the genetic paradigm for brain research. In I. Lieblich (Ed.), Genetics of the Brain. New York: Elsevier.

    Google Scholar 

  • Lorens, S. A., Goldberg, H. C., Hole, K., Kohler, C., & Srebro, B. (1976). Activity, avoidance learning and regional 5-hydroxytryptamine following intrabrain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat. Brain Research, 108, 97–113.

    Article  PubMed  CAS  Google Scholar 

  • Maurer, R. G., & Damasio, A. R. (1982). Childhood autism from the point of view of behavioral neurology. Journal of Autism and Developmental Disorders, 12, 195–205.

    Article  PubMed  CAS  Google Scholar 

  • McGraw, M. B. (1946). Maturation of behavior. In L. Carmichael (Ed.), Manual of child psychology. New York: Wiley.

    Google Scholar 

  • Milner, B. (1976). CNS maturation and language acquisition. In H. Whitaker & H. A. Whitaker (Eds.), Studies in neurolinguistics. New York: Academic Press.

    Google Scholar 

  • Miranda, M., Botti, D., Ragnelli, A. M., & diCola, M. (1982). A study on melanogenesis and catecholamine biosynthesis during Bufo bufo development. J. Exp. Zool., 224(2), 217–222.

    Article  PubMed  CAS  Google Scholar 

  • Myers, R. E., Swett, C., & Miller, M. (1973). Loss of social group affinity following prefrontal lesions in free-ranging macaques. Brain Research, 64, 257–269.

    Article  PubMed  CAS  Google Scholar 

  • Ojemann, G. A. (1976). Subcortical language mechanisms. In H. Whitaker & H. A. Whitaker (Eds.), Studies in Neurolinguistics. New York: Academic Press.

    Google Scholar 

  • O’Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. New York: Oxford University Press.

    Google Scholar 

  • Ornitz, E. M. (1974). The modulation of sensory input and motor output in autistic children. Journal of Autism and Childhood Schizophrenia, 4, 197–215.

    Article  PubMed  CAS  Google Scholar 

  • Ornitz, E. M. (1978). Biological homogeneity or heterogeneity? In M. Rutter & E. Schopler (Eds.), A reappraisal of concepts and treatment. New York: Plenum Press.

    Google Scholar 

  • Ornitz, E. M. (1983). The functional neuroanatomy of infantile autism. International Journal of Neuroscience, 19, 85–124.

    Article  PubMed  CAS  Google Scholar 

  • Ornitz, E. M. (1985). Neurophysiology of infantile autism. Journal of the American Academy of Child Psychiatry, 24, 251–262.

    Article  PubMed  CAS  Google Scholar 

  • Ornitz, E. M., Guthrie, D., & Farley, A. J. (1978). The early symptoms of childhood autism. In G. Serban (Eds.), Cognitive defects in the development of mental illness. New York: Brunner/Mazel.

    Google Scholar 

  • Parmelee, A. H., & Sigman, M. (1976). Development of visual behavior & neurological organization on pre-term and full-term infants. In A. D. Pick (Ed.), Minnesota Symposia on Child Psychology (Vol. 10). Minneapolis: University of Minnesota Press.

    Google Scholar 

  • Parnavelas, J. G. (1978). Influence of stimulation of cortical development. In M. A. Corner, R. E. Baker, N. E. van de Poll, D. F. Swaab, & H. B. M. Uylings (Eds.), Maturation of the nervous system, Progress in Brain Research, 48, 247–259.

    Chapter  Google Scholar 

  • Pomperano, O. (1967a). The neurophysiologic mechanisms of the postural and motor events during desynchronized sleep. Research Publications, Association for Research in Nervous and Mental Disease, 45, 351–423.

    Google Scholar 

  • Pomperano, O. (1967b). Sensory inhibition during motor activity in sleep. In M. D. Yahr & D. P. Purpura (Eds.), Neurophysiological basis of normal and abnormal motor activities. New York: Hewlett, Raven Press.

    Google Scholar 

  • Reichler, R. J., & Schopler, E. (1971). Observations on the nature of human relatedness. Journal of Autism and Childhood Schizophrenia, 1, 283–296.

    Article  PubMed  CAS  Google Scholar 

  • Reichler, R. J., & Schopler, E. (1976). Developmental therapy: A program model. In E. Schopler & R. J. Reichler (Eds.), Psychopathology and child development. New York: Plenum Press.

    Google Scholar 

  • Ritvo, E. R., & Freeman, B. J. (1978). National Society for Autistic Children definition of the syndrome of autism. Journal of the American Academy of Child Psychiatry, 17, 565–576.

    Article  PubMed  CAS  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins. American Journal of Psychiatry, 142, 74–77.

    PubMed  CAS  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Scheibel, A. B., Duong, P. T., Robinson, H., & Guthrie, D. (1986). Decreased Purkinje cell density in four autistic patients: Initial findings of the UCLA-NSAC Autopsy Research Project. American Journal of Psychiatry, 43(7), 862–866.

    Google Scholar 

  • Ritvo, E. R., Spence, M. A., Freeman, B. J., Mason-Brothers, A., Mo, A., & Marazita, M. L. (1985). Evidence for autosomal recessive inheritance in 46 families with multiple incidence of autism. American Journal of Psychiatry, 142, 187–192.

    PubMed  CAS  Google Scholar 

  • Rumsey, J. M., Duara, R., Grady, C., Rapoport, J. L., Margolin, R. A., Rapoport, S. I., & Cutler, N. R. (1985). Brain metabolism in autism. Archives of General Psychiatry, 42, 448–455.

    Article  PubMed  CAS  Google Scholar 

  • Rutter, M. (1978). Diagnosis and definition of childhood autism. Journal of Autism and Childhood Schizophrenia, 8, 139–161.

    Article  PubMed  CAS  Google Scholar 

  • Rutter, M., Bartak, L., & Newman, S. (1971). Autism—A central disorder of cognition and language? In M. Rutter (Ed.), Infantile autism: Concepts, characteristics and treatment. London: Churchill- Livingstone.

    Google Scholar 

  • Rutter, M., & Lockyer, L. (1967). A five to fifteen year follow-up study of infantile psychosis. I. Description of the sample. British Journal of Psychiatry, 113, 1169–1182.

    Article  PubMed  CAS  Google Scholar 

  • Sackett, G. P. (1972). Isolation rearing in monkeys: Diffuse and specific effects on later behavior. Colloques Internationaux du C.N.R.S., No. 198, Modèles animaux du comportement humain.

    Google Scholar 

  • Schneider, A. M., & Tarshis, B. (1980). An introduction to physiological psychology (2nd ed.). New York: Random House.

    Google Scholar 

  • Schopler, E., Reichler, R. J., DeVillis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103.

    Article  PubMed  CAS  Google Scholar 

  • Schopler, E., Reichler, R. J., & Renner, B. R. (1986). The Childhood Autism Rating Scale (CARS): For diagnostic screening and classification of autism. New York: Irvington.

    Google Scholar 

  • Schopler, E., & Rutter, M. (1978). Subgroups vary with selection purpose. In M. Rutter & E. Schopler (Eds.), Autism: A reappraisal of concepts and treatment (pp. 507–517). New York: Plenum Press.

    Google Scholar 

  • Shaywitz, B. A., Cohen, D. J., Leckman, J. F., Young, J. G., & Bowers, M. B. (1980). Ontogeny of dopamine and serotonin metabolities in the cerebrospinal fluid of children with neurological disorders. Developmental Medicine and Child Neurology, 22, 748–754.

    Article  PubMed  CAS  Google Scholar 

  • Spence, M. A. (1976). Genetic studies. In E. Ritvo (Ed.), Autism: Diagnosis, current research and management (pp. 169–174). New York: Halstead/Wiley.

    Google Scholar 

  • Spyer, K. M., Ghelarducci, B., & Pompeiano, O. (1973). Responses of brain stem reticular neurons to tilting. Brain Research, 56, 321–326.

    Article  Google Scholar 

  • Stubbs, E. G., Ritvo, E. R., & Mason-Brothers, A. (1985). Autism and shared parental HLA antigens. Journal of the American Academy of Child Psychiatry, 24, 182–185.

    Article  PubMed  CAS  Google Scholar 

  • Tanguay, P. E., & Edwards, R. M. (1982). Electrophysiological studies of autism: The whisper of the bang. Journal of Autism and Developmental Disorders, 12, 172–184.

    Article  Google Scholar 

  • Young, J. G., Cohen, D. J., Caparulo, B. K., Brown, S., & Maas, J. W. (1979). Decreased 24-hour urinary MHPG in childhood autism. American Journal of Psychiatry, 136, 1055–1057.

    PubMed  CAS  Google Scholar 

  • Young, J. G., Kavanagh, M. E., Anderson, G. M., Shaywitz, B. A., & Cohen, D. J. (1982). Clinical neurochemistry of autism and associated disorders. Journal of Autism and Developmental Disorders, 12, 147–165.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Child at Risk Project, Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, 98104, USA

    Robert Jay Reichler & Eugene M. C. Lee

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  1. Robert Jay Reichler
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  2. Eugene M. C. Lee
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  1. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Eric Schopler  & Gary B. Mesibov  & 

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Reichler, R.J., Lee, E.M.C. (1987). Overview of Biomedical Issues in Autism. In: Schopler, E., Mesibov, G.B. (eds) Neurobiological Issues in Autism. Current Issues in Autism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1992-2_2

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  • DOI: https://doi.org/10.1007/978-1-4899-1992-2_2

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