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The Neuropsychology of Alzheimer’s Disease

  • Chapter
Handbook of Neuropsychology and Aging

Part of the book series: Critical Issues in Neuropsychology ((CINP))

Abstract

Alzheimer’s disease (AD) is a progressive degenerative brain disorder that results in a profound global dementia characterized by severe amnesia with additional deficits in language, “executive” functions, attention, and visuospatial and constructional abilities (Corkin, Davis, Growdon, Usdin, & Wurtman, 1982; Katzman, 1986). Because dementia is associated with more than 50 different causes of brain dysfunction (Haase, 1977; Katzman, 1986) and because there are no known peripheral markers for AD, the disease can only be definitively diagnosed by histopathological verification of the presence of characteristic neurodegenerative abnormalities (i.e., neuritic plaques and neurofibrillary tangles; Khachaturian, 1985). However, documentation of the presence of dementia and the exclusion of all other known potential causes allows probable or possible AD to be clinically diagnosed during life with some certainty (Galasko et al., 1994; Kawas, 1990; McKhann et al., 1984).

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Authors and Affiliations

  1. Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0948, USA

    David P. Salmon

  2. Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0948, USA

    Mark W. Bondi

  3. San Diego Department of Veterans Affairs Medical Center, San Diego, California, 92161, USA

    Mark W. Bondi

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  1. David P. Salmon
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Editors and Affiliations

  1. Aging Research and Education Center, Lutheran Affiliated Services, Mars, Pennsylvania, 16046, USA

    Paul David Nussbaum

  2. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261, USA

    Paul David Nussbaum

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Salmon, D.P., Bondi, M.W. (1997). The Neuropsychology of Alzheimer’s Disease. In: Nussbaum, P.D. (eds) Handbook of Neuropsychology and Aging. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1857-4_10

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