Abstract
Dipodascopsis uninucleata, a lipomycetaceous mycelial yeast with a well-defined life cycle, synthesises small amounts of arachidonic acid (ARA) and also produces the novel pharmacologically active metabolite, 3-hydroxyarachidonic acid (3-hydroxyeicosatetraenoic acid, 3-HETE) from exogenous ARA during its sexual phase (van Dyk et al, 1991; Kock et al, 1997). The production of 3-HETE from exogenous ARA and both ascosporogenesis and ascospore production in D. uninucleata were all inhibited by 1 mM aspirin (van Dyk et al, 1991; Botha et al, 1992; Coetzee et al, 1992).
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Akpinar, A., Fox, S.R., Ratledge, C., Friend, J. (1997). Biotransformation of Arachidonic Acid and Other Eicosanoids by the Yeast Dipodascopsis uninucleata, the Oomycete Fungi Saprolegnia diclina and Leptomitus lacteus and the Zygomycete Fungus Mortierella isabellina . In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_49
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_49
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