Abstract
Although prostacyclin (PGI2) is more commonly known for its important role as an antithrombotic agent, there is accumulating evidence suggesting that PGI2 has additional neuronal activity. For example, the PGI2 analogue cicaprost can stimulate the release of tachykinins from guinea-pig ileum (Jones and Lawrence, 1993), and can inhibit the spontaneous contractile activity of rat colon by stimulating the release of factors involved in nonadrenergic noncholinergic neurotransmission (Qian and Jones, 1995). Furthermore, the activation of IP-receptors in the rat enteric nervous system appears to be mediated by a novel IP-receptor subtype, distinct from the IP-receptor associated with inhibition of platelet aggregation (Wise et al., 1995). This novel IP-receptor was identified by testing some non-prostanoid PGI2 mimetics which, while active in inhibiting rat neutrophil aggregation, were without effect in the rat colon.
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References
Hirata, M., Ushikubi, F. and Narumiya, S., 1995, J. Lipid Mediators Cell Signalling, 12: 393.
Jones, R.L. and Lawrence, R.A., 1993, Pharmacol. Commun. 3: 147.
Jones, R.L., Qian, Y., Wise, H., Wong, H.N.C., Lam, W.L., Chan, H.W., Yim, A.P.C., and Ho, J.K.S., 1997, J. C. ardiovasc. Pharmacol. in press.
Katsuyama, M., Sugimoto, Y., Namba, T., Irie, A., Negishi, M., Narumiya, S. and Ichikawa, A., 1994, FEBS Lett. 344: 74.
Kelly, E., Keen, M., Nobbs, P. and MacDermot, J., 1990, Br. J. Pharmacol. 99: 309.
Matsumura, K., Watanabe, Y., Onoe, H. and Watanabe, Y., 1995, Neurosa. 65: 493.
Meanwell, N. A., Romine, J. L., and Seiler, S. M., 1994, Drugs of the Future, 19: 361.
Nakagawa, O., Tanaka, I., Usui, T., Harada, M., Sasaki, Y., Itoh, H., Yoshimasa, T., Namba, T., Narumiya, S. and Nakao, K., 1994, Circ. 90: 1643.
Oida, H., Namba, T., Sugimoto, Y., Ushikubi, F., Ohishi, H., Ichikawa, A. and Narumiya, S., 1995, Br. J. Pharmacol. 116: 2828.
Qian, Y. and Jones, R.L., 1995, Br. J. Pharmacol. 115: 163.
Ross, R.A., Spengler, B.A. and Biedler, J.L., 1983, J Natl. Cancer Inst. 71: 741.
Sasaki, Y., Usui, T., Tanaka, I., Nakagawa, O., Sando, T., Takahashi, T., Namba, T., Narumiya, S. and Nakao, K., 1994, Biochim. Biophys. Acta 1224: 601.
Takechi, H., Matsumura, K., Watanabe, Y., Kato, K., Noyori, R. and Suzuki, M., 1996, J. Biol. Chem. 271: 5901.
Wise, H., 1996, Prostaglandins Leuk. Essen. Fatty Acids 54: 351.
Wise, H., and Jones, R. L., 1994, Br J Pharmacol. 113: 581.
Wise, H., Qian, Y. & Jones, R.L., 1995, Eur. Pharmacol. 278, 265.
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Wise, H., Chow, K.B.S. (1997). The Effect of Non-Prostanoid Prostacyclin Mimetics on Cyclic AMP Production by Neuronal SK-N-SH Cells. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_41
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