Skip to main content

Anti-Tumor-Promoting Activities of Triterpenoid Glycosides; Cancer Chemoprevention by Saponins

  • Chapter
Saponins Used in Traditional and Modern Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 404))

Abstract

The mechanism of chemical carcinogenesis has been explained by either a two-stage theory or a multi-stage theory which consists of initiation, promotion and progression stages.1 In these stages, the promotion stage is long-term and reversible reaction, and the development of anti-tumor-promoters has been regarded as the most effective method for the chemoprevention of cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. I. Berenblum, The mechanism of carcinogenesis, a study of the significance of cocarcinogenic action and related phenomea, Cancer Res., 1: 807 (1941)

    CAS  Google Scholar 

  2. T. Konoshima, E. Okamoto, M. Kozuka, H. Nishino, H. Tokuda, and M. Tanabe, Studies on inhibitors of skin tumor promotion, III. Inhibitory effects of isoflavonoids from Wistaria brachybotrys on Epstein-Barr virus activation, J. Nat. Prod., 51: 1266 (1988); M. Takasaki, T. Konoshima, M. Kozuka, and H. Tokuda, Anti-tumor-promoting activities of euglobals from Eucalyptus plants, Biol. Pharm. Bull., 18: 435 (1995).

    Google Scholar 

  3. T. Konoshima, M. Takasaki, M. Kozuka, T. Nagao, H. Okabe, N. Irino, T. Nakatsu, H. Tokuda, and H. Nishino, Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor II., Biol. Pharm. Bull.,18: 284 (1955), and references cited there in.

    Google Scholar 

  4. T. Konoshima, M. Kozuka, M. Haruna, and K. Ito, Constituents of Leguminous plants, XIII, New triterpenoid saponins from Wistaria brachybotrys, J. Nat. Prod., 54: 830 (1991).

    Article  PubMed  CAS  Google Scholar 

  5. I. Kitagawa, M.’ Yoshikawa, H.K. Wang, M. Saito, V. Tosirisuk, T. Fujiwara, and K. Tomita, Revised structures of soyasapogenol A, B and E, oleanene-sapogenols from soybean. Structures of soyasaponin I, II and III, Chem. Pharm. Bull., 30: 2294 (1982).

    Article  CAS  Google Scholar 

  6. T. Konoshima, and T. Sawada, Legume saponins of Gleditsia japonica Miguel IV, 13C-NMR spectral studies on structure elucidation of saponin B and C, Chem. Pharm. Bull.,30: 2747 (1982), and references cited therein.

    Google Scholar 

  7. T. Konoshima, M. Kozuka, T. Sawada, and T. Kimura, Studies on the constituents of Leguminous plants IX, The structure of new triterpenoid saponin from the fruits of Gymnocladus chinensis Baillon, Chem. Pharm Bull.,35: 46 (1987), and references cited therein.

    Google Scholar 

  8. Tanaka and R. Kasai, Progress in the Chemistry of Organic Natural Products, W. Herz, H. Grisebach, G.W. Kirby, and Ch. Tamm, Ed, Springer-Verlag, New York (1984); I. Kitagawa, T. Taniyama, T. Hayashi, and M. Yoshikawa, Malonyl ginsenosides Rb,, Rb2 and Rd, four new malonylated dammarane-type triterpene glycosides from ginseng radix, Chem. Pharm. Bull., 31: 3353 (1983); S. Sanada, N. Kondo, J. Shoji, O. Tanaka, and S. Shibata, Studies of saponins of ginseng I, structures of ginsenoside-Ro, -Rb„ -Rb2, -Rc and -Rd, Chem. Pharm. Bull., 22: 421 (1974).

    Google Scholar 

  9. H. Matsuura, R. Kasai, O. Tanaka, Y. Saruwatari, T. Fuwa, and J. Zhou, Further studies on dammaranesaponins of Sanchi-ginseng, Chem. Pharm. Bull., 31: 2281 (1983).

    Article  CAS  Google Scholar 

  10. H. Yamaguchi, R. Kasai, H. Matsuura, 0. Tanaka, and T. Fuwa, High-performance liquid chromatographic analysis of acidic saponins of ginseng and related plants, Chem. Pharm. Bull., 36: 3468 (1988).

    Article  PubMed  CAS  Google Scholar 

  11. T. Konoshima, M. Takasaki, H. Tokuda, and H. Nishino, Chemopreventive effects of Panax notoginseng on hepatic carcinogenesis, Proc. 10th Symposium on the Development aryl Application of Naturally Occurring Drug Materials (Chiba) p. 45 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Konoshima, T. (1996). Anti-Tumor-Promoting Activities of Triterpenoid Glycosides; Cancer Chemoprevention by Saponins. In: Waller, G.R., Yamasaki, K. (eds) Saponins Used in Traditional and Modern Medicine. Advances in Experimental Medicine and Biology, vol 404. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1367-8_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1367-8_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1369-2

  • Online ISBN: 978-1-4899-1367-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics