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Hemolytic Activity of Triterpene Glycosides from the Dendrochirotida Order Holothurian

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Saponins Used in Traditional and Modern Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 404))

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Abstract

Triterpene glycosides from sea cucumbers are taxonomically specific,complicated and variable in their chemical structures and biological activities1. As well known cytotoxic, antifungal, and hemolytic effects of glycosides correlate with each other and due to the glycoside membranotropic action2,3. Hemolytic activity was used as a measure of membranolytic action of these glycosides. Previously we studied the influence of a sulfate group at C-4 of the first xylose residue and length of the carbohydrate chain on the hemolytic activity of triterpene glycosides from Cucumariidae family holothurians4. However, questions concerning the influence on the membranolytic activity of sulfate groups attached to the C-6 position of monosaccharide residues in the carbohydrate chains, 3-Omethyl groups in terminal monosaccharide residues, and 16 -oxo groups in aglycones with the 7(8)-double bond remained unresolved. Herein we report studies on hemolytic activity of glycosides and their derivatives from the sea cucumber order Dendrochirotida which attempt to resolve the above-mentioned questions.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry of Far East Division, Russian Academy of Sciences, 690022, Vladivostok, Russia

    Vladimir I. Kalinin, Nina G. Prokofieva, Galina N. Likhatskaya, Elena B. Shentsova, Irina G. Agafonova, Sergey A. Avilov & Olga A. Drozdova

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  1. Vladimir I. Kalinin
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  2. Nina G. Prokofieva
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  3. Galina N. Likhatskaya
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  4. Elena B. Shentsova
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  5. Irina G. Agafonova
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  6. Sergey A. Avilov
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  7. Olga A. Drozdova
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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Oklahoma State University, 246B Noble Research Center, 74078-0454, Stillwater, Oklahoma, USA

    George R. Waller

  2. Institute of Pharmaceutical Science School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734, Japan

    Kazuo Yamasaki

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© 1996 Springer Science+Business Media New York

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Kalinin, V.I. et al. (1996). Hemolytic Activity of Triterpene Glycosides from the Dendrochirotida Order Holothurian. In: Waller, G.R., Yamasaki, K. (eds) Saponins Used in Traditional and Modern Medicine. Advances in Experimental Medicine and Biology, vol 404. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1367-8_46

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  • DOI: https://doi.org/10.1007/978-1-4899-1367-8_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1369-2

  • Online ISBN: 978-1-4899-1367-8

  • eBook Packages: Springer Book Archive

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