Abstract
In healthy individuals, renal clearance maintains tissue and plasma concentrations of aluminium at very low levels. Elevated levels are found in patients on renal dialysis, with dialysis solutions (dialysate) containing trace levels of Al; a further risk results from an associated long term use of Al-based phosphate binders. Among dialysis patients Al has been implicated as the causative agent of encephalopathy, osteomalacia, osteodystrophy, anaemia and general malaisel. There is no easy, noninvasive, method of investigating Al overload. Measurements of Al concentration in plasma give only an estimate of recent exposure, while estimates of long-term exposure can be derived from analysis of iliac crest biopsy samples that are obtained by a painful procedure, not suitable for serial measurements.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
M.E. DeBroe and F.L. Van de Vyver (eds), Aluminium: a clinical problem in nephrology. Clin. Nephrol, 24 suppl 1: (1985)
E.D.Williams, A.L. Elliott, K. Boddy, J.K. Haywood, I.S. Henderson, T. Harvey and A.C. Kennedy. Whole body aluminium in chronic renal failure and dialysis encephalopathy. Clin Nephrol 14: 198 (1980)
K.J. Ellis and S.P. Kelleher. In-vivo bone aluminium measurements in patients with renal disease, in Proc. of Int. Symp on in vivo body composition studies (Chapter 73) KJ. Ellis, S. Yasumura & W.D. Morgan BNL (1986), publ. by IPSM (York) (1987)
W.D. Morgan, E.A. McNeil, R.M. Wyatt, SJ.S. Ryde, C.J. Evans, J. Dutton, A. Sivyer and A.J. Williams. Development of a technique to measure bone aluminium in vivo using a Cf-252 neutron source, in Proc. Int Symp. on in vivo body composition studies, S. Yasumura, J.E. Harrison, K.G. McNeil, A.D. Woodhead & F.A. Dilmanian. Plenum Press, NY. (1990)
ICRU 1983 Report 36, Microdosimetry, International Commission on Radiation Units and Measurements (Washington DC: ICRU )
D.W. Marquardt. An algorithm for least squares estimation of non-linear parameters. J.Soc. Indust. Appl Math, 11: 431 (1963)
S.R. Wagner, B. Grosswendt, J.R. Harvey, A.J. Mill, H.J. Sellback, B.R.L. Siebert. Unified conversion functions for the new ICRU operational radiation protection quantities. Radial. Prot. Dos. 12: 231 (1985).
ICRP 1973 Publication 21, Data for Protection Against Ionising Radiation from external sources (Suppl to Publication 15 ) ( Oxford: Pergamon Press )
S. Green and D.R. Chettle. A feasibility study of the in vivo measurement of aluminium in peripheral bone. Phys. Med. Biol (In Press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Green, S., Bradley, D.A., Mountford, P.J., Morgan, W.D., Chettle, D.R., Weaver, D.R. (1993). Characteristics of an Accelerator Based System for in Vivo Aluminium Measurement in Peripheral Bone. In: Ellis, K.J., Eastman, J.D. (eds) Human Body Composition. Basic Life Sciences, vol 60. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1268-8_64
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1268-8_64
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1270-1
Online ISBN: 978-1-4899-1268-8
eBook Packages: Springer Book Archive