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Changes of Arterial Endothelial Cells in Chronic Hypertension with Special Reference to Regressive Changes and Replication

  • Chapter
Endothelial Cell Dysfunctions

Abstract

Hypertension is a potent risk factor for atherosclerosis and causes hypertensive vascular changes by itself. On the other hand, injuries to endothelial cells have been shown to be a possible initiating event in atherogenesis1,2 as well as in the development of hypertensive arterial changes.3,4 Therefore, information about the morphological and functional changes of endothelial cells associated with chronic hypertension and the mechanisms by which hypertension injures endothelial cells is indispensable for a better understanding of the pathogenesis of atherosclerosis and hypertensive vascular changes. Recently it has been found that endothelial cells contain factors related to the contraction, dilation, migration, and proliferation of medial smooth muscle cells. Therefore, it is possible that endothelial cells have an important role in the regulation of the vascular functions. Information about the effects of chronic hypertension on such regulating mechanisms of endothelial cells is also very important.

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Author information

Authors and Affiliations

  1. Department of Pathology, Shiga University of Medical Science, Seta, Otsu, 520-21, Japan

    Fumitada Hazama & Masakiyo Sasahara

Authors
  1. Fumitada Hazama
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  2. Masakiyo Sasahara
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Editors and Affiliations

  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

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Hazama, F., Sasahara, M. (1992). Changes of Arterial Endothelial Cells in Chronic Hypertension with Special Reference to Regressive Changes and Replication. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_16

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  • DOI: https://doi.org/10.1007/978-1-4899-0721-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0723-3

  • Online ISBN: 978-1-4899-0721-9

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