Skip to main content
SpringerLink
Log in

Biomedical Use of Arsenic Radioisotopes

  • Chapter
New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control

Abstract

The availability of several radioisotopes of arsenic allows for their use as tracers in biochemical, environmental and medical applications. The versatility of arsenic to be incorporated into various chemical structures, and the existence of a wide array of arsenic compounds with established chemistries, permit the synthesis of radiopharmaceuticals with potential utility in therapy and diagnosis of numerous disease states. The current goals of several investigators are to establish methods of routine production and purification of selected arsenic radioisotopes, and to develop synthetic pathways for labeling compounds useful in medical and toxicological research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H. A. Schroeder and J. J. Balassa, J. Chronic. Dis. 19: 85 (1966).

    Article  PubMed  CAS  Google Scholar 

  2. R. Brock, Nature, 195: 841 (1962).

    Article  Google Scholar 

  3. Handbook of Chemistry and Physics, CRC Press 19.

    Google Scholar 

  4. R. S. Goldsmith, Infectious Disease: Protozoal, it “Current Medical Diagnosis and Treatment, M. A. Krupp and M.J. Chatton, eds., Lange Medical Publications, Los Altos, California (1979).

    Google Scholar 

  5. T. Sollmann, “Manual of Pharmacology,” W. B. Saunders Co., Philadelphia (1957).

    Google Scholar 

  6. C. H. Banks, J. R. Daniel, and R. A. Zingaro, J. Medicinal Chem. 22: 572 (1979).

    Article  CAS  Google Scholar 

  7. M. M. Swann, Cancer Res. 17: 727 (1957).

    Google Scholar 

  8. Proceedings of Arsenic Symposium, National Bureau of Standards, Gaithersburg, Maryland, 1981.

    Google Scholar 

  9. G. O. Coak, L. D. Freedman, “Organometallic Compounds of Arsenic, Antimony and Bismuth,” Dictmar Seyferth, ed., John Wiley and Sons, Inc., New York (1970).

    Google Scholar 

  10. M. Dub, ed., Organometallic Compounds: Vol. III; Compounds of Arsenic, Antimony, and Bismuth, 2nd edition, Springer-Verlag, Inc., New York (1968).

    Google Scholar 

  11. K. M. Smith, ed, “Porphyrins and Metalloporphyrins,” Elsevier Scientific Publishing Co., New York (1975).

    Google Scholar 

  12. F. Hosain, P. K. Sripada, P. Hosain, A. Emran, and R. P. Spencer, Substitution of Arsenic for Phosphorus, La: “Radiopharmaceuticals: Structure Activity Relationships,” R. P. Spencer, ed., Grune and Straton, New York (1981).

    Google Scholar 

  13. L. Goetz and H. Norin, Int. J. Appl. Radiat. !sot, 34 (11): 1509 (1983)

    Article  CAS  Google Scholar 

  14. A. M. Emran, N. M. Shanbaky, and R. P. Spencer, Int. J. Appl. Radiat. ‘sot. 37: 545 (1986).

    Article  CAS  Google Scholar 

  15. K. Heydorn, Chin. Chem.-Acta 28: 349, 1970.

    Article  CAS  Google Scholar 

  16. R. D. Hood and S. L. Bishop, Arch. Environ. Health 24: 62 (1972).

    Article  PubMed  CAS  Google Scholar 

  17. W. R. Byron, G. W. Bierbauer, J. B. Brouyer, and W. H. Hansen, Toxicol. Appl. Pharmacol. 16: 132 (1967).

    Article  Google Scholar 

  18. B. D. Obermeyer, I. S. Palmer, O. E. Olson, and A. W. Halverson, Toxicol. Appl. Pharmacol. 20: 135 (1971).

    Article  PubMed  CAS  Google Scholar 

  19. F. A. Patty, Arsenic, Phosphorus, Selenium, Sulfur, and Tellurium, in “Industrial Hygiene and Toxicology,” D. W. Fassett and D. D. Irish, eds., Interscience, New York, (1963).

    Google Scholar 

  20. Registry of Toxic Effects of Chemical Substances, Richard J. Lewis, Sr., ed., National Institute for Occupational Safety and Health, Cincinnati, Ohio, 1979.

    Google Scholar 

  21. P. M. Grant, D. A. Miller, J. S. Gilmore, H. A. O’Brien, Jr., Int. J. Appl. Radiat. Isot, 33: 415 (1982).

    Article  CAS  Google Scholar 

  22. D. R. Phillips, D. C. Moody, W. A. Taylor, N. J. Segura, and B. D. Pate, Int. J. Appl. Radiat. Isot. 38:521 (1987).

    Google Scholar 

  23. A. M. Emran, and D. R. Phillips, Potential Applications of Arsenic Isotopes, in Proceedings of the 196th National Meeting of the American Chemical Society, Los Angeles, September, 1988.

    Google Scholar 

  24. D. R. Phillips, D. A. Nix, and A. M. Emran, Progress on an Electrolytic 72Se/72As Radiochemical Generator, in Proceedings of the International Chemical Congress of Pacific Basin Societies, Honolulu, December, 1989.

    Google Scholar 

  25. C. Birattari, M. Bonardi, and A. Salomone, J. Label. Comp. Radiooharm XVIII: 253 (1988).

    Google Scholar 

  26. S. H. Al-Kouraishi, and G. G. J. Boswell, Int. J. Aool. Radiat. and Isot. 2:(607).

    Google Scholar 

  27. G. B. S. Rayudu, Seminars in Nbclear Medicine XX: 100 (1990).

    Google Scholar 

  28. T. E. Ward, D. L. Swindle, R. J. Wright, and P. K. Kuroda, Radiochimica Acta 11: 70 (1970).

    Google Scholar 

  29. F. Hosain, A. Emran, R. P. Spencer and K. S. Clampitt, Int. J. App’, Radiat. Isot. 33: 1477 (1982).

    Google Scholar 

  30. R. Weinreich, R. Schwarzbach, A. B. Alfassi, and P. Smith-Jones, J. Label, Comp. Radiopharm. X XVI (1989).

    Google Scholar 

  31. M. Inarida, A. Shimamura, Radioanal. Letters 2: 87 (1969).

    CAS  Google Scholar 

  32. T. J. Ruth, B. D. Pate, R. Robertson, and J. K. Porter, 16: 323 (1989).

    CAS  Google Scholar 

  33. M. Guillaume, R. M. Lambrecht, A. P. Wolf, Int. J. Appl. Radiat. and Isot. 29: 411 (1978).

    Article  CAS  Google Scholar 

  34. J. J. La Brecque and I. L. Preiss, J. !nor. and Nucl. Chem. 38: 2139 (1976).

    Article  Google Scholar 

  35. Y. Wang, ed., “Handbook of Radioactive Nuclides”, Chemical Rubber Co., Cleveland (1969).

    Google Scholar 

  36. H. C. Beard and J. G. Cuninghame, “Radiochemistry of Arsenic,” United States Atomic Energy Commission, Springfield, VA (1965).

    Google Scholar 

  37. A. M. Emran and R. P. Spencer, Unpublished data on 77As production.

    Google Scholar 

  38. J. R. Arnold and N. Sugarman, J. Chem. Phys. 15: 703 (1947).

    Article  CAS  Google Scholar 

  39. R. S. Mani, Research Reactor Production of Radioisotopes for Medical Use, in “Radiopharmaceuticals and Labeled Compounds, 1984, Tokyo Conference Proceedings, IACE, Vienna (1985).

    Google Scholar 

  40. C. Michael Lederer and Virginia S. Shirley, eds., Table of Isotopes, John Wiley and Sons, Inc., New York, 1978.

    Google Scholar 

  41. Amersham Corporation, “Research Products.”

    Google Scholar 

  42. Medical Radioisotopes Research Program, Los Alamos National Laboratory, Los Alamos, New Mexico.

    Google Scholar 

  43. F. A. Cotton and G. Wilkinson, “Advanced Inorganic Chemistry,” Third Edition, Interscience Publishers, New York (1972).

    Google Scholar 

  44. J. C. Thorpe and M. A. Whitley, eds., “Thorpe’s Dictionary of Applied Chemistry, Vol. I, Longmans Publishers, London (1969).

    Google Scholar 

  45. D. Basile, C. Birattari, M. Bonardi, L. Goetz, E. Sabbioni, and A. Salomone, Int. J. Aopl. Radiat. Isotopes 32: 403 (1981).

    Article  CAS  Google Scholar 

  46. G. Forsberg, J. W. O’Laughlin, R. G. Megargle, and S. R. Koirtyohann, Anal., Chem. 47: 1586 (1975).

    Article  CAS  Google Scholar 

  47. E. M. Donaldson, Talanta 24: 105 (1977).

    Google Scholar 

  48. E. M. Donaldson, Talanta 35: 47 (1988).

    Google Scholar 

  49. E. Henden, Anal. Chim. Acta 173: 89 (1985).

    Article  CAS  Google Scholar 

  50. W. D. SpaII, J. G. Lynn, J. L. Andersen, J. JG. Valdez, and L. R. Gurley, Anal. Chem. 58: 1340 (1986).

    Google Scholar 

  51. V. I. Rigin, J. Anal. Chem. -USSR 38: 806 (1983).

    Google Scholar 

  52. W. Holak, Journal of the AOAC 59: 650 (1976).

    CAS  Google Scholar 

  53. T. E. Ward, D. L. Swindle, R. J. Wright, and P. K. Kuroda, Radiochimica Acta 11: 70 (1970).

    Google Scholar 

  54. D. R. Phillips, V. T. Tate, W. A. Taylor, R. C. Staroski, R. A. Lopez, Recovery of Germanium, Selenium, and Arsenic Radioisotopes from Proton Irradiated RbBr, manuscript in preparation.

    Google Scholar 

  55. S. A. Amankwah, and J. L. Fasching, Talanta 32: 111 (1985).

    Article  PubMed  CAS  Google Scholar 

  56. Y. M. Yukhim, V. V. Sergeeva, and V. P. Litvinov, Industrial Laboratory-USSR 45: 979 (1979).

    Google Scholar 

  57. M Inarida, A. Shimamura, Radiochem. Radioanal. Letters 2: 87 (1969).

    CAS  Google Scholar 

  58. A. R. Casai and M. S. Zalba, AFINIDAD 38: 405 (1981).

    Google Scholar 

  59. A. R. Casai and M. S. Zalba Annales de Quimica Serie B-Quimica Inorganica Y Quimica Analytica 81: 203 (1985).

    Google Scholar 

  60. S. S. Sandhu, and P. Nelson, in Proceedings of the April, 1979 Meeting of the American Chemical Society, 1979, 280 (1979).

    Google Scholar 

  61. G. Aliotta and D. P. Desilvetti, Anales de la Associacion Quimica Argentina 66: 1 (1978).

    CAS  Google Scholar 

  62. R. Lagunas, D. Pestana, and J. C. Diezmasa, Biochemistry 23: 955 (1984).

    Article  PubMed  CAS  Google Scholar 

  63. M. Braungart and H. Russel, Chromatographia 19: 185 (1989).

    Article  Google Scholar 

  64. Z Hu and Y. B. Tang, Analyst 113: 179 (1988).

    Article  PubMed  CAS  Google Scholar 

  65. A. Watson, Mikrochimica Acta 2: 157 (1976).

    Article  CAS  Google Scholar 

  66. Cadet, Mem. Math Phys. 3: 623 (1760).

    Google Scholar 

  67. H Bart, Ger. Pat. 250,264 (Jan. 8, 1910), Cf. CA= 6, 3312 (1912).

    Google Scholar 

  68. H. P. Brown and C. S. Hamilton, J. Amer. Chem. Soc. 56: 151 (1934).

    Article  CAS  Google Scholar 

  69. G. Meyer, 132L. 16: 1439 (1883).

    Google Scholar 

  70. K. W. Rosenmund, Ber. 54: 438 (1921).

    Google Scholar 

  71. K. Irgolic, R. A. Zingaro, and M. R. Smith, J. Organometal. Chem. 12: 377 (1968).

    Article  Google Scholar 

  72. G. O. Doak, H. Eagle, and H. G. Steinman, J. Amer. Chem. Soc. 62: 168 (1940).

    Article  CAS  Google Scholar 

  73. J. F. Oneto and E. L. Way, J. Amer. Chem. Soc. 63: 762 (1941).

    Article  CAS  Google Scholar 

  74. E. L. Way and J. F. Oneto, J. Amer. Chem. Soc. 64: 1287 (1942).

    Article  CAS  Google Scholar 

  75. J. F. Norris, Ind. Eng. Chem. 11: 817 (1919).

    Google Scholar 

  76. C. Walling and S. A. Buckler, J. Amer. Chem. Soc. 77: 6032 (1955).

    Article  CAS  Google Scholar 

  77. F. Sachs and K. Kantorowiez Ber. 41: 2767 (1908).

    CAS  Google Scholar 

  78. K. Matsumiya and M. Nakai, Mem. Coll. Sci.. Koyoto Imp. Univ. 8A 309 (1925) cf. CA, 19, 3086 (1925).

    Google Scholar 

  79. G. Newberry and M. A., J. Chem. Soc. 2375 (1928).

    Google Scholar 

  80. E. J. Cragoe, R. J. Andres, R. F. Coles, B. Elpern, J. G. Morgan, and C. S. Hamilton, J. Amer. Chem. Soc. 69: 925 (1947).

    Article  CAS  Google Scholar 

  81. W. C. Johnson and A. Pechukas, J. Amer. Chem. Soc, 59: 2068 (1937).

    Article  CAS  Google Scholar 

  82. L. Schmerling (To Universal Oil Products Co.), U. S. Pat. 2,842,579 (July 8, 1958), cf. CA 55, 497 (1961).

    Google Scholar 

  83. E. R. H. Jones and F. G. Mann, J. Chem. Soc. 294 (1958).

    Google Scholar 

  84. E. Miller, B. Teissier, H. Eggensperger, A. Reiker, and K. Scheffler, J. L. Ann. Chem, 705: 54 (1967).

    Article  Google Scholar 

  85. D. E. Worral, J. Amer. Chem. Soc, 52: 664 (1930).

    Google Scholar 

  86. F. G. Mann and J. Watson, J. Chem. Soc. 505 (1947).

    Google Scholar 

  87. M. Kraft, and S. A. Rossina, Dokl. Acad. Nauk SSSR 55: 821 (1947).

    CAS  Google Scholar 

  88. G. A. Rasuwajew and M. Malinowsk, Ber. 64: 120 (1931).

    Google Scholar 

  89. G. K. H. Tam, S. M. Charbonneau, G. Lacroix, and F. Bryce, Bull. Environ. Contam. Toxicol. 21: 371 (1979).

    Article  PubMed  CAS  Google Scholar 

  90. S. M. Charbonnequ, J. G. Hollins, G. K. H. Tam, G. Bryce, J. M. Ridgeway, and R. F. Willes, Toxicology Letters 5: 175 (1980).

    Article  Google Scholar 

  91. S. A. Lerman, T. W. Clarkson, and R. J. Gerson Chem.-Biol. Interactions 45: 401 (1983).

    Article  CAS  Google Scholar 

  92. M. Vahter and E. Marafante, Chem.-Biol. Interactions 47: 29 (1983).

    Article  CAS  Google Scholar 

  93. E. Marafante and M. Vahter, Chem.-Biol. Interactions 50: 49 (1984).

    Article  CAS  Google Scholar 

  94. Private communications between one of the authors (DRP) and numerous arsenic radioisotope users.

    Google Scholar 

  95. R. L. Junkins, V. Schultz, A. W. Klement, Jr., Arsenic and Its Radioisotopes in the Environs, in “Radioecology, Proceedings of the National Symposium on Radioecology 1st,” Van Nostrand-Reinhold, New York (1963).

    Google Scholar 

  96. R. C. Ball and F. H. Hooper, Use of 74As-Tagged Sodium Arsenite in a Study of Effects of a Herbicide on Pond Ecology, in “Proceedings of the Symposium on the Use of Isotopes in Weed Research,” International Atomic Energy Agency (1966).

    Google Scholar 

  97. J. Oughton, Rept. Ent. Soc. Ont., 81:91, as referenced by D. W. Jenkins, Radioisotopes in Ecological and Biological Studies of Agricultural Insects, in “Proceedings of the Symposium on Radioisotopes and Radiation in Entomology,” International Atomic Energy Agency, Vienna (1962).

    Google Scholar 

  98. G. L. Brownell and W. H. Sweet, Nucleonics 11: 40 (1953).

    Google Scholar 

  99. W. H. Sweet and G. L. Brownell, J.A.M.A. 157: 1183 (1955).

    Article  CAS  Google Scholar 

  100. J. R. Mallard, J. F. Fowler, and M. Sulton, Br. J. Radiol. 34: 562 (1961).

    Article  PubMed  CAS  Google Scholar 

  101. W. Paul and R. H. Botterell, J. Nucl. Med. 4: 1 (1963).

    PubMed  CAS  Google Scholar 

  102. P. A. Farrer and J. McRae, Australian Annals of Medicine 12: 93 (1963).

    CAS  Google Scholar 

  103. P. Benda, M. David, and J. Constans, Rev. Neurol 89: 101 (1953).

    Google Scholar 

  104. J. Mealey, G. L. Brownell, and W. H. Sweet, Arch. Neurol. Psychiat. 81: 310 (1959).

    Article  CAS  Google Scholar 

  105. R. G. Long, J. G. McAfee, and J. Winkelman, Cancer Res. 23: 98 (1963).

    Google Scholar 

  106. C. M. E. Matthews and G. Molinaro, Brit. J. Exp. Path. 44: 260 (1963).

    CAS  Google Scholar 

  107. J. L. Mego and J. D. McQueen, Cancer Res. 23: 523 (1963).

    PubMed  CAS  Google Scholar 

  108. J. D. McQueen and J. L. Mego, Neurosurgery 21: 641 (1964).

    Article  CAS  Google Scholar 

  109. R. G. Ojemann, S. Aronow, and W. H. Sweet, Neurosurgery 22: 489 (1965).

    Article  CAS  Google Scholar 

  110. Leicester and G. K. Vanerfield, The Medical Journal of Australia Part 2, Page 680, October 8, 1966.

    Google Scholar 

  111. P. Hosain, P. K. Sripada, R. P. Spencer, and F. Hosain, Int. J. Nucl Med. and Biol. 8: 209 (1981).

    Article  CAS  Google Scholar 

  112. A. M Emran, F. Hosain, and R.P Spencer, J. Nucl. Med. 23: 100 (1982).

    Google Scholar 

  113. A. M. Emran, F. Hosain, and R. P. Spencer, J. Label. Comp. Radiooharm. XIX: 1505 (1982).

    Google Scholar 

  114. A. Emran, F. Hosain, R. P. Spencer, and K S. Kolstad, Int. J. Nucl. Med. Biol. 11: 259 (1984).

    Article  PubMed  CAS  Google Scholar 

  115. Private communication with S. Larsen and J. Mercer-Smith.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cyclotron Facility, Positron Diagnostic and Research Center The University of Texas Health Science Center, Houston, Texas, USA

    Ali M. Emran

  2. Isotopes and Nuclear Chemistry Group 11, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

    Dennis R. Phillips

Authors
  1. Ali M. Emran
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dennis R. Phillips
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Texas Health Science Center, Houston, Texas, USA

    Ali M. Emran

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Emran, A.M., Phillips, D.R. (1991). Biomedical Use of Arsenic Radioisotopes. In: Emran, A.M. (eds) New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0626-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0626-7_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0628-1

  • Online ISBN: 978-1-4899-0626-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation