Abstract
A statistical model is given to describe the electrical activity patterns of large neural populations of the hippocampal CA3 region. The population model incorporates basic electrophysiological properties of hippocampal pyramidal and inhibitory neurons. Population activities as well as underlying single cell voltages are simulated during normal and epileptiform activities in the CA3 region of the hippocampus. It is demonstrated that our model can reproduce electrophysiological phenomena characteristic to both single cell and population activities. Specifically, the intrinsic burst response of individual pyramidal cells to injected currents, fully synchronized population bursts, sustained multiple population bursts, synchronized synaptic potentials, and low amplitude population oscillation were obtained.
This work was supported by the OTKA grant F014020, by the exchange program between the Hungarian Academy of Sciences and the Consiglio Nazionale delle Ricerche (Italy), and by the Fogarty International Research Collaboration Award, HHS Grant No. 1 R03 TW00485-01.
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Gröbler, T., Barna, G. (1997). Single Cell and Population Activity in a Statistical Model of the Hippocampal CA3 Region. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9800-5_53
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DOI: https://doi.org/10.1007/978-1-4757-9800-5_53
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