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Exo-Endocytotic Recycling of Synaptic Vesicles in Developing Neurons

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Botulinum and Tetanus Neurotoxins

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Abstract

Regulated secretion of neurotransmitters from neurons involves a cocktail of neurotransmitter molecules and at least two classes of secretory organdies: synaptic vesicles (SVs) and large dense core vesicles (LDCVs). SVs are small vesicles highly homogeneous in size (about 50 nm) which are clustered under the presynaptic plasmalemmma and contain non-peptide neurotransmitters.Their exocytosis is responsible for the fast, point-to-point signalling typical of synaptic transmission. LDCVs are larger organelles with an electron dense core which contain neuroactive peptides and may also contain amines. Their exocytosis is involved in a slower, modulatory intercellular signalling.

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Author information

Authors and Affiliations

  1. CNR Center of Cytopharmacology and Department of Medical Pharmacology, University of Milano, Italy

    Michela Matteoli

  2. Howard Hughes Medical Institute and Department of Cell Biology, Yale University Medical School, USA

    Pietro De Camilli

Authors
  1. Michela Matteoli
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  2. Pietro De Camilli
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Editor information

Editors and Affiliations

  1. University of Wisconsin, Madison, Wisconsin, USA

    Bibhuti R. DasGupta

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© 1993 Springer Science+Business Media New York

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Matteoli, M., De Camilli, P. (1993). Exo-Endocytotic Recycling of Synaptic Vesicles in Developing Neurons. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_17

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  • DOI: https://doi.org/10.1007/978-1-4757-9542-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9544-8

  • Online ISBN: 978-1-4757-9542-4

  • eBook Packages: Springer Book Archive

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