Summary
43 patients with Wegener’s granulomatosis were studied to evaluate the effectiveness of cyclophosphamide (cyc) pulse treatment. 42% of the patients showed benefits from treatment for at least 6 months after the cessation of cyc pulses. Analysis of clinical and laboratory parameters indicate that this treatment is less effective in patients in whom more than 4 organ systems are involved. Responders to the treatment showed disease manifestations predominantly in the ENT and lower respiratory tract and had lower cANCA titers ( < 1:64) prior to treatment.
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References
De Vita, S., Neri, R., and Bombardieri, S., 1991, Cyclophosphamide pulses in the treatment of rheumatic diseases: an update, Cin.Exp.Rheumatol 9: 179.
Haubitz, M., Frei, U., Rother, U., Brunkhorst, R., and Koch, K.M., 1991, Cyclophosphamide pulse therapy in Wegener’s granulomatosis, NephrolDial Transplant. 6: 531.
Hoffman, G.S., Kerr, G.S., Leavitt, R.Y., Hallahan, C.W., Lebovics, R.S., Travis, W.D., Rottem, M., and Fauci, A.S., 1992, Wegener granulomatosis: An analysis of 158 patients, Ann.Intern.Med. 116: 488.
Hoffman, G.S., Leavitt, R.Y., Fleisher, T.A., Minor, J.R., and Fauci, A.S., 1990, Treatment of Wegener’s granulomatosis with intermittent high-dose intravenous cyclophosphamide, Am.J.Med. 89: 403.
Schmitt, W.H., Heesen, C., Csernok, E., Rautmann, A., and Gross, W.L., 1992, Elevated serum levels of soluble interleukin-2 receptor (sIL-2R) in Wegener’s granulomatosis (WG): Association with disease activity, Arthritis Rheum. 35: 1088.
Steppat, D. and Gross, W.L., 1989, Stage-adapted treatment of Wegener’s granulomatosis, Klin. Wochenschr. 67: 666.
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© 1993 Springer Science+Business Media New York
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Reinhold-Keller, E., Kekow, J., Schnabel, A., Schwarz-Eywill, M., Schmitt, W.H., Gross, W.L. (1993). Effectiveness of Cyclophosphamide Pulse Treatment in Wegener’s Granulomatosis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_87
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_87
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