Summary
Sera from 210 patients with APSGN, were tested for the presence of ANCA (IgG-isotype). Indirect immunofluorescence (IF) on ethanol fixed human PMNs was used, and for those positive sera, ELISA kits for PR3 (Proteinase 3) and MPO (Myeloperoxidase) was performed. ANCA were detected in 9% (18 out of 210 cases) in a predominantly diffuse cytoplasmic staining pattern in 14 cases (77%), and in a perinuclear pattern in the remaining 4 cases (22%). Anti-MPO was found in 4 cases (C-ANCA 3; P-ANCA 1) and anti-PR3 was always negative. The presence of ANCA was significantly associated with a more severe glomerular disease as assessed by the serum creatinine value and the crescents formation.
Longitudinal studies performed in 11 cases have shown that raised levels of these autoantibodies may persist for at least six months, without relationship with disease activity.
Further studies are required to dilucidate the specificity of these autoantibodies, and if its presence is either an epiphenomenon of the heterogeneous humoral immune response in streptococcal infection, or they play some pathogenic role in APSGN.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Savage,C.O., Lockwood C.M. 1990. Autoantibodies in primary systemic vasculitis. Adv Intern Med 35: 73–92.
Falk R.J. 1990. ANCA-associated renal disease. Kidney Int. 38: 998–1010.
Jenette J.Ch., Falk R.J. 1990. Antineuthrophil cytoplasmic autoantibodies and associated diseases: a review. Am. J. Kidney Dis. X V: 517–529.
Mezzano S., Burgos M.E., Ardiles L. et al. 1992 Glomerular localization of platelet factor 4 in streptococcal nephritis. Nephron61: 58–63.
Van der Woude F.J., Rasmussen N., Lobatto S. et al. 1985. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet 1: 425–429.
Falk R.J., Jenette J. Ch. 1991. Wegener’s granulomatosis, systemic vasculitis, and antineutrophil cytoplasmic autoantibodies. Annu. Rev. Med. 42: 459–469.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mezzano, S. et al. (1993). Antineutrophil-Cytoplasmic-Autoantibodies in Poststreptococcal Nephritis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_80
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9182-2_80
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
eBook Packages: Springer Book Archive