Abstract
Cognitive and memory impairment is a frequent finding in patients with Parkinson’s disease (PD) (Taylor et al., 1986; Growdon and Corkin, 1986) and in depression (Sternberg and Jarvik, 1976; Wertman et al., 1993). Heterogeneity of memory dysfunction in different neurological illnesses has recently raised interest. The impaired memory in the PD patients has been suggested to be an indication of mild frontal lobe dysfuntion (Taylor et al., 1986). In positron emission tomography, depression in PD has been associated with hypometabolism in the inferior frontal lobe and the caudate nucleus (Mayberg et al., 1990). Structural changes in the caudate nucleus and white matter in magnetic resonance imaging have been associated with late age onset depression (Figiel et al., 1990). Despite similar memory dysfunction, the underlying cognitive processes contributing to dysfunction may differ. We, therefore, examined working memory, learning ability, and retrieval from semantic memory and their relationship to frontal dysfunctions in PD patients, in depressive patients and in controls.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
American Psychiatric Association, 1980, Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: American Psychiatric Association.
Borkowski, J.G., Benton, A.L., and Spreen, O., 1967, Word fluency and brain damage, Neuropsychologia 5: 135–140.
Brown, R.G., and Mardsen, C.D., 1988, Subcortical dementia: the neuropsychological evidence, Neuroscience 25: 363–387.
Figiel, G.S., Krishnan, R.R., Doraiswamy, P.M., Rao, V.P., Nemeroff, C.B., and Boyko, O.B., 1990, Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects. Neurobiol. Aging 26: 245–247.
Growdon, J.H., and Corkin, S., 1986, Cognitive impairment in Parkinson’s disease, Adv Neurol. 45: 383–392.
Helkala E.-L., Laulumaa, V., Soininen, H., Riekkinen, P.J., 1988, Recall and recognition memory in patients with Alzheimer’s and Parkinson’s diseases, Ann. Neurol. 24: 214–217.
Hoehn, M.M., and Yahr, M.D., 1967, Parkinsonism: onset, progression and mortality, Neurology 17: 427–442.
Mayberg, H.S., Starkstein, S.E., Sadzot, B., Preziosi, T., Andrezejewski, P.L., Dannals, R., Wagner, H.N., and Robinson, R.G., 1990, Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinon’s disease, Ann. Neurol. 28: 57–64.
Milner, B., 1971, Interhemispheric differences in the localization of psychological processes in man, Br. Med. Bull. 27: 272.
Moss, M.B., Albert, M.S., Butters, N., Payne, M., 1986, Differential patterns of memory loss among patients with Alzheimer’s disease, Huntington’s disease, and alcoholic Korsakoff s syndrome, Arch. Neurol. 43: 239–246.
Nelson, H.E., 1976, A modified card sorting test sensitive to frontal lobe defects, Cortex 12: 313–324.
Reitan, R.M., 1958, Validity of the Trail making test as an indicator of organic brain damage, Percept. Mot. Skills 8: 271–276.
Russell, E.W., 1975, A multiple scoring method for the assessment of complex memory functions. J. Consult. Clin. Psychol. 43: 800–809.
Sternberg, D.E., Jarvik, M.E., 1976, Memory functions in depression: improvement with antidepressant medication, Arch. Gen. Psychiatry 433: 219–224.
Stroop, J.R., 1935, Studies of interference in serial verbal reaction, J. Exp. Psychol. 18: 643.
Taylor, A.E., Saint-Cyr, J.A., Lang, A.E., Kenny, F.T., 1986, Parkinson’s disease and depression. A critical re-evaluation, Brain 109: 279–292.
Taylor, A.E.,. Saint-Cyr, J.A., Lang, A.E., 1990, Memory and learning in early Parkinson’s disease: Evidence for a “frontal lobe syndrome”, Brain Cogn. 13: 211–232.
Wechsler, D., 1981, WAIS-R Manual, New York, Psychological Corporation.
Wellman, E., Speedie, L., Shemesh, Z., Gilon, D., Raphael, M., Stessman, J., 1993, Cognitive disturbances in Parkinsonian patients with depression, Neuropsychiatry, Neuropsychology Behay. Neurol. 6: 31–37.
Wolfe, N., Katz, D.I., Albert, M.L., Almozlino, A., Durso, R., Smith, M.C., Volker, L., 1990, Neuropsychological profile linked to low dopamine: in Alzheimer’s disc acP major depression, and Parkinson’s disease, J. Neurol. Neurosurg. Psychiatry 53: 915–917.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Helkala, EL., Laulumaa, V., Järvinen, J., Riekkinen, P. (1995). Frontal Dysfunction and Memory Deficit in Depression and Parkinson’s Disease. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_10
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9145-7_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9147-1
Online ISBN: 978-1-4757-9145-7
eBook Packages: Springer Book Archive