Abstract
The genetic analyses of aggression in mammals begins with two articles published almost sixty years agog1, 2. In both the C57BL10, C3H and BALB/c inbred strains were used, and in both the strains differed in measures of aggression. This was the first evidence that genes had a role in individual differences in aggression of any mammal. Both groups believed that their findings were relevant to other animals, especially humans Later, Scott3 wrote in the book Aggression: “It is the purpose of this book to take the important results from current animal research and relate or contrast them with the facts of human behavior.”
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References
Ginsburg, B. G. and Allee, W. C., 1942, Some effects of conditioning on social dominance and subordination in inbred strains of mice. Physiot Zool. 15: 485–506.
Scott, J. P., 1942, Genetic differences in the social behavior on inbred strains of mice. J Hered 33: 11–15.
Scott, J. P., 1958, Aggression. University of Chicago Press. Chicago.
Sandnabba, N. K, 1996, Selective breeding for isolation-induced aggression in mice: Associated responses and environmental influences. Behay. Genet. 26: 477–488.
Gariepy, J.-L., Lewis, M. H., and Cairns, R. H., 1996, Genes, neurobiology and aggression: Time frames and functions of social behaviors in adaptation. In Aggression and Violence: Genetic, Neurobiological and Biosocial Perspectives (D. M. Stoff and R. B. Cairns, eds.), Lawrence Erlbaum Associates. Manwah, N. J., pp. 41–63.
Sluyter, F., Van Oortmerssen, G. A., Ruiter, A. J. H., and Koolhaas, J. M.,1996, Aggression in wild house mice: Current state of affairs. Behay. Genet. 26: 489–495.
Maxson, S.C., 1998, Homologous genes, aggression and animal models. bevel. Neuropsychol. 14: 143–156.
Maxson, S. C., 1999, Genetic influences on aggressive behavior. In Genetic Influences on neural and behavioral functions ( D. Pfaff, W. Berrettini, T. Joh, and S. Maxson eds.), CRC Press, Boca Raton, pp. 405–416.
Miczek, K. A., Masson, S. C., Fish, E. W. and Faccidomo, S., submitted, Aggressive behavioral phenotypes in mice. Behavioral Brain Research
Alleva, E., Cirulli, F., Bianchi, M., Bondiolotti, G. P., Chiarotti, F., DeAcetis, L. and Panerai, A., 1995, Behavioral characterization of interlukin-6 overexpression or deficit mice during agonsitic encounters. Eur. J. Neurosci. 10: 3664–3672.
Maxson, S. C., Ginsburg, B. and Trattner A., 1979, Interaction of Y-chromosomal gene (s) in the development of intermale aggression in mice. Behay. Genet. 9: 219–226.
Stewart, A. D., Manning, A., Batty J., 1980, Effects on Y chromosome variants on the male behaviour of the mouse Mus musculus. Genet. Res. (Cambr.) 35: 261–268.
Carlier, M., Roubertoux, P. L. and Pastoret, C., 1991, The Y chromosome effect on intermale aggression in mice depends on the maternal environment. Genet. 129: 23l - 236.
Van Oortmerssen, G.A., 1984, A behavioral-genetic approach to variation in attack latency, serum testosterone level, and other agonistic parameters. Aggress. Behay. 10: 177–178.
Van Oortmerssen, G. A., and Sluyter, F., 1994, Studies in wild house mice: V. Aggression in selection lines for attack latency and their congenics for the Y chromosome. Behay. Genet. 24, 73–78.
Carlier, M., Roubertoux, P. L., Kottler, M. L. and Degrelle, H., 1990, Y chormosome and aggression in strains of laboratory mice. Behay. Genet. 20: 137–156.
Simmler M. C., Rouyer, F., Vergnaud, G., Nystrom-Lahti, M., K. Ngo, K. Y.,De la Chapelle, A. and Weissenbach, J., 1985, Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes. Nature 317: 692–697.
Ellis, E. and Goodfellow, P. N., 1989, The mammalian pseudoautosomal region. T Genet. 5: 406–410.
Selmanof£ M. K., Maxson, S. C. and Ginsburg, B., 1976, Chromosomal determinants of intermale aggressive behavior in inbred mice. Behay. Genet. 6: 53–69.
Cartier, M. and Roubertoux, P. L., 1986, Differences between CBA/H and NZB mice on intermale aggression. I. Comparison between parental strains and reciprocal Fls, In Genetic Approaches to Behavioral Phenotypes ( J. Medioni and G. Vaysse, eds.) Privat, Toulouse. pp. 47–57.
Roubertoux, P. L. and Carlier, M., 1988, Differences between CBA/H and NZB on intermale aggression II–Maternal effects, Behay. Genet. 18: 175–184.
Selmanoff, M. K., Jummonville, J. E., Maxson, S. C., and Ginsburg, B. E., 1975, Evidence for a Y chromosome contribution to an aggressive phenotype in mice. Nature 253: 529–530.
Bailey, D. W., 1985, Genes that effect the shape of the murine mandible. Congenic strain analysis. J Hered. 76: 107–114.
Moutier, R. and Carlier M.,1991, Mandible shape analysis in Y-congenic strains of mice. Lab. Anim. 25: 303–307.
Roubertoux, P. L, Carlier, M., Degrelle, H., Haas-Dupertuis, M. C., Phillips, J., and Moutier, R., 1994, Co-segregation of the pseudoautosomal region of the Y chromosome with aggression in mice. Genet. 135: 254–263.
Guillot P., Carlier M. and Roubertoux P.L., 1995, The Y chromosome effect on intermale aggression in mice depends on the test situation and on the recorded variables. Behay. Genet. 25: 51–59.
Roubertoux, P.L., Le Roy I., Tordjman S., Mortaud S. and Carlier, M.,1999, Measuring aggression in the Mouse. In Molecular genetic Techniques for Behavioral Neuroscienc,. (W. E. Crusio and R Gerlai, eds.), Elsevier, Amsterdam, pp. 696–709
Roubertoux, P. I.., Degrelle, H., Maxson, S. C., Phillips, J., Tordjman, S., and DupertuisHaas, M. -C., 1994, Polymorphism for the alleles of the microsomal steroid sulfatase gene (Sts) in the pseudoautosomal region of the heterosomes of laboratory mice. C. lt Acad. Sci. Paris, 317: 523–527.
Mortaud, S., Donnes-Dared, E., Roubertoux, P. L., and Degrelle, H., 1995, Murine steroid sulfatase (mSTS): purification, characterization and measurement by ELISA. J. Ster. Biochem. Mol. Biol. 52: 91–96.
Le Roy, I., Mortaud, S., Tordjman, S., Donsez-Darcel, E., Carlier, M., Degrelle, H., Roubertoux, P.L.,1999, Genetic correlation between expression of the steroid sulfatase gene, mapped on the pairing region of the Y-chromosome, and initiation of attack behavior in mice. Behay. Genet. 29, 131–136.
Maxson, S. C., 1996, Searching for candidate genes with effects on an agonistic behavior, offense, in mice Behay. Genet. 26, 471–476.
Roubertoux, P.L., Mortaud, S., Tordjman, S., Le Roy,I. and Degrelle, H., 1998, Behavior-genetic analysis and aggression: the mouse as a prototype In Advances in Psychological Science: Biological and Cognitive Aspects. (M. Sabourin, F. Craik. and M. Robert eds,), Psychology Press, London, pp. 3–29.
Saudou, F., Amara, D. A., Dierich, A., Lemeur, M., Ramboz, S., Segu, L., Buhot, M.-C., and Hen, R., 1994, Enhanced aggressive behavior in mice lacking 5-HT I B receptor, Science, 265, 1875–1878.
König, M., Zimmer, A. M.,Steiner, H., Holmes, P., Crawley, J., Brownstein, M. J., and Zimmer, A., 1996,. Pain response and aggression in mice deficient in pre-proenkephalin. Nature 383: 535–538.
Chen, C., Rainnie, D. G., Greene, R W., and Tonegawa S., 1994, Abnormal fear responses and aggressive behavior in mutant mice deficient for a-calcium-calmodulin kinase-II. Science 266: 291–294.
Mathis, C., Paul, S. M., and Crawley, J. N., 1994, The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharm. 116: 201–206.
Cloninger, CR, 1987, Neurogenetic adaptive mechanisms in alcoholism Science, 236, 410–416
Kitties, R A, Long, J. C., Bergen, A. W., Eggert, M., Virkkunen, M., Linnoila, M., and Goldman, D., 1999, Cladistic association analysis of Y chromosome effectson alcohol dependence and related personality traits. Proc. Natl. Acad Sci. USA. 96: 4204–4209.
Lappalainen, J., Long, J.C., Eggert, M., Ozaki, N., Robin, R.W., Brown, G.L., Naukkarinen, H., Virkkunen, M., Linnoila, M., and Goldman, D., 1998, Linkage of antisocial alcoholism to the serotonin 5-HT! B receptor gene in 2 populations. Arch Gen. Psychiatry 55: 989–94.
Brunner, D, and Hen, R., 1997, Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Ann. N YAcad Sci. 836: 81–105.
Enoch, M. A. and Goldman, D., 1999, Genetics of alcoholism. In: Genetic Influences on neural and behavioral functions ( D. Pfaff, W. Berrettini, T. Joh, and S. Masson, eds.), CRC Press, Boca Raton, pp. 147–157.
Brunner, H. G., 1996, MAOA deficiency and abnormal behaviour: perspectives on an association. In: Genetics of Criminal and Antisocial Behaviour (G. R. Brock and J. A. Goode, eds.), Wiley, New York, pp. 155–64; discussion pp. 164–167.
Hauser P., McMillin, J. M. and Bhatara, V. S., 1996, Resistance to thyroid hormone: implications for neurodevelopmental research on the effects of thyroid hormone disruptors. Taxied! Ind Health 14: 85–101.
Blanchard, D. C., Hebert, M., and Blanchard, R. J., 1999, Continuity versus (political) correctness: animal models and human aggression. In Animal Models of Human Emotion and Cognition ( M. Haug and R. E. Whalen, eds.) American Psychological Association, Washington, DC, pp. 297–316.
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Maxson, S.C., Roubertoux, P.L., Guillot, P., Goldman, D. (2001). The genetics of aggression. In: Martinez, M. (eds) Prevention and Control of Aggression and the Impact on its Victims. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6238-9_8
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DOI: https://doi.org/10.1007/978-1-4757-6238-9_8
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