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Regulatory Mechanism of Expression of LPS Binding Site(S) and Signaling Events by LPS in Macrophages

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Endotoxin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Lipopolysaccharide (LPS) from gram-negative microorganisms is a potent activator of macrophages. LPS induces macrophages to secrete immunoregulatory substances including interleukin 1 (IL 1), tumor necrosis factor (TNF), interferon, colony stimulating factors (CSFs) and, prostaglandins. Furthermore LPS activates tumor cytotoxicity of macrophages by itself or in combination with interferon.

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Author information

Authors and Affiliations

  1. Department of Cellular Immunology, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

    K. S. Akagawa, K. Kamoshita & T. Tokunaga

  2. The Medical Institute, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108, Japan

    T. Tomita & T. Yasuda

Authors
  1. K. S. Akagawa
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  2. K. Kamoshita
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  3. T. Tomita
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  4. T. Yasuda
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  5. T. Tokunaga
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Akagawa, K.S., Kamoshita, K., Tomita, T., Yasuda, T., Tokunaga, T. (1990). Regulatory Mechanism of Expression of LPS Binding Site(S) and Signaling Events by LPS in Macrophages. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_42

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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