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Lessons to better understanding of hypoxia sensing

Acquired and congenital mutations resulting in polycythemia

  • Chapter
Hypoxia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 502))

Abstract

Adaptation of the organism to hypoxia has profound effect on multiple tissues including regulation of erythropoiesis, vasculogenesis, a proper regulation of embryogenesis as well as other functions. The elucidation of those congenital or acquired mutations giving rise to disease states affecting physiological systems devoted to oxygen homeostasis provides not only a practical diagnostic and potential therapeutic target, but also allows to identify the essential, non-redundant physiological pathways that may be hitherto unknown. The erythropoietin gene was the first gene expression found to be upregulated by hypoxia; the mechanism of this regulation lead to our current understanding of hypoxia sensing. Thus it is appropriate that the disorders resulting from augmented erythropoiesis are subject of this review.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA

    Josef T. Prchal

  2. Departments of Biology and Hematology/Oncology, Faculty of Medicine, Palacky University, Olomouc, 775 15, Czech Republic

    Vladimir Divoky

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  1. New Mexico Resonance, Montezuma, New Mexico, USA

    Robert C. Roach

  2. University of California, San Diego, La Jolla, California, USA

    Peter D. Wagner

  3. International Society for Mountain Medicine, Ridgeway, Colorado, USA

    Peter H. Hackett

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Prchal, J.T., Divoky, V. (2001). Lessons to better understanding of hypoxia sensing. In: Roach, R.C., Wagner, P.D., Hackett, P.H. (eds) Hypoxia. Advances in Experimental Medicine and Biology, vol 502. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3401-0_13

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  • DOI: https://doi.org/10.1007/978-1-4757-3401-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3374-4

  • Online ISBN: 978-1-4757-3401-0

  • eBook Packages: Springer Book Archive

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