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Different Doses of Fish — Oil Fatty Acid Ingestion in Active Rheumatoid Arthritis: A Prospective Study of Clinical and Immunological Parameters

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Dietary ω3 and ω6 Fatty Acids

Abstract

Lee, et al, have demonstrated that fish — oil ingestion leads to decreased production of leukotriene B4 (LTB4) derived from arachidonate through the 5-lipoxygenase pathway with the new production of leukotriene B5 (LTB5) from EPA(1). Since LTB4 is a potent inflammatory and chemotactic compound, a decrease in its production could favorably affect the clinical manifestations of an inflammatory disease like rheumatoid arthritis. It was not surprising, then, when we observed improvement in certain clinical manifestations of rheumatoid arthritis which were significantly correlated with decreased production of neutrophil LTB4 in patients receiving fish — oil(2).

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Authors and Affiliations

  1. Division of Rheumatology, Department of Microbiology/Immunology, Albany Medical College and Albany Veteran’s Administration Hospital, Albany, New York, USA

    Joel M. Kremer, David A. Lawrence & William Jubiz

Authors
  1. Joel M. Kremer
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  2. David A. Lawrence
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  3. William Jubiz
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Editor information

Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Claudio Galli

  2. ILSI Research Foundation, Washington, D.C., USA

    Artemis P. Simopoulos

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© 1989 Springer Science+Business Media New York

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Kremer, J.M., Lawrence, D.A., Jubiz, W. (1989). Different Doses of Fish — Oil Fatty Acid Ingestion in Active Rheumatoid Arthritis: A Prospective Study of Clinical and Immunological Parameters. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_31

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  • DOI: https://doi.org/10.1007/978-1-4757-2043-3_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2045-7

  • Online ISBN: 978-1-4757-2043-3

  • eBook Packages: Springer Book Archive

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