Skip to main content

Characteristics of Stimulant Drug Reinforcement

  • Chapter
Stimulus Properties of Drugs

Abstract

A number of stimuli serve as reinforcers for operant behavior. These stimuli unify the many and varied responses leading to their presentation, and make the behavioral unit formed more likely to recur. Apart from these effects, however, reinforcers seemingly have little else in common. They differ physically over a wide range, including such dissimilar events as food, light and novel stimulus presentation, electric shock termination, and electrical stimulation of the brain. It is not surprising therefore that the functional properties of reinforcers also differ. In fact, each reinforcer appears to have a set of unique characteristics. In the present chapter, some of the characteristics of stimulant drugs as reinforcers are examined, with special consideration given to the behavior of the organism under such conditions and to factors influencing this behavior.

Preparation of this chapter was supported in part by USPHS Research Grants No. MH-14112 and MH-15349 to the University of Minnesota.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Axelrod, J. Metabolism of epinephrine and of the sympathomimetic amines. Physiol. Rev., 1959, 39, 751.

    PubMed  CAS  Google Scholar 

  • Davis, J.D. A method for chronic intravenous infusion in freely moving rats. J. Exp. Anal. Behav., 1966, 9, 385.

    Article  PubMed  CAS  Google Scholar 

  • Deneau, G.A., and Inoki, R. Nicotine self-administration in monkeys. Ann. N.Y. Acad. Sci., 1967, 242, 277.

    Article  Google Scholar 

  • Deneau, G.A., Yanagita, T., and Seevers, M.H. Self-administration of drugs by monkeys. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1964.

    Google Scholar 

  • Eddy, N.B., Halback, H., Isbell, H., and Seevers, M.H. Drug dependence: Its significance and characteristics. Bull. WHO, 1965, 32, 721.

    PubMed  CAS  Google Scholar 

  • Ellis, S. The metabolic effects of epinephrine and related amines. Pharmacol. Rev., 1956, 8, 485.

    PubMed  CAS  Google Scholar 

  • Estrada, U., Villarreal, J.E., and Schuster, C.R. Self-administration of stimulant drugs as a function of the dose per injection. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1967.

    Google Scholar 

  • Goth, A. Medical Pharmacology. St. Louis, The C.V. Mosby Co., 1968.

    Google Scholar 

  • Griffith, J. A study of illicit amphetamine drug traffic in Oklahoma City. Amer. J. Psychiat., 1966, 123, 560.

    PubMed  CAS  Google Scholar 

  • Jaffe, J.H. Drug addiction and drug abuse. In L.S. Foodman and A. Gilman, eds., The Pharmacological Basis of Therapeutics. New York, The Macmillan Company, 1965.

    Google Scholar 

  • Jarvik, M.E. Tobacco smoking in monkeys. Ann. N. Y. Acad. Sci., 1967, 142, 280.

    Article  Google Scholar 

  • Kosman, M.E., and Unna, K.R. Effects of chronic administration of the amphetamines and other stimulants on behavior. Clin. Pharmacol. Ther., 1968, 9, 240.

    PubMed  CAS  Google Scholar 

  • Kramer, J.C., Fischman, V.S., and Littlefield, D.C. Amphetamine abuse. JAMA, 1967, 201, 89.

    Article  Google Scholar 

  • Leake, C.D. The Amphetamines: Their Actions and Uses. Springfield, Ill., Charles C Thomas, Publisher, 1958.

    Google Scholar 

  • McGuire, L.E. Reinforcing effects of intravenously-infused morphine and 1-methamphetamine. Unpublished doctoral dissertation. University of Mississippi, 1966.

    Google Scholar 

  • Muscholl, E. Indirectly acting sympathomimetic amines. Pharmacol. Rev., 1966, 18, 551.

    PubMed  CAS  Google Scholar 

  • Pickens, R. Self-administration of stimulants by rats. The International Journal of the Addictions, 1968, 3, 215.

    Google Scholar 

  • Pickens, R. and Harris, W.C. Self-administration of d -amphetamine by rats. Psychopharmacologia, 1968, 12, 158.

    Article  PubMed  CAS  Google Scholar 

  • Pickens, R. and Thompson, T. Self-administration of amphetamine and cocaine by rats. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1967.

    Google Scholar 

  • Pickens, R. and Thompson, T. Cocaine-reinforced behavior in rats: Effects of reinforcement magnitude and fixed-ratio size. J. Pharmacol. Exp. Ther., 1968, 161, 122.

    PubMed  CAS  Google Scholar 

  • Pickens, R., Bloom, W., and Thompson, T. Response rate as a function of long session lengths and large reinforcement magnitudes. Proceedings American Psychological Association, 1969, 809–810.

    Google Scholar 

  • Pickens, R., Dougherty, J.A., and Thompson, T. Effects of volume and duration of infusion on cocaine reinforcement, with concurrent activity recording. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1969.

    Google Scholar 

  • Pickens, R., Meisch, R.A., and Dougherty, J.A. Effects of behavioral and biochemical manipulations on methamphetamine self-administration in the rat. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1968a.

    Google Scholar 

  • Pickens, R. , Meisch, R.A., and Dougherty, J.A. Chemical interactions in methamphetamine reinforcement. Psychol. Rep., 1968(b), 23, 1267.

    Article  PubMed  CAS  Google Scholar 

  • Pickens, R. , Meisch, R., and McGuire, L.E. Methamphetamine reinforcement in rats. Psychonomic Science, 1967, 8, 371.

    Google Scholar 

  • Schuster, C.R., Woods, J.H., and Seevers, M.H. Self-administration of central stimulants by the monkey. Presented at Symposium on Abuse of Central Stimulants, Karolinska Institute, Stockholm, Sweden, 1968.

    Google Scholar 

  • Seevers, M.H. and Deneau, G.A. Physiological aspects of tolerance and physical dependence. In W.S. Root and F.G. Hofmann, eds., Physiological Pharmacology. Volume I. New York, Academic Press, Inc., 1963, 565.

    Google Scholar 

  • Thompson, T., and Pickens, R. Drug self-administration and conditioning. In H. Steinberg, ed., Scientific Basis of Drug Dependence. London, J. & A. Churchill, Ltd., 1968.

    Google Scholar 

  • Seevers, M.H. and Pickens, R. Behavioral variables influencing drug self-administration. In R.T. Harris, W.M. Mclsaac, and C.R. Schuster, eds., Drug Dependence. Austin, University of Texas Press, 1970.

    Google Scholar 

  • Weiss, B., and Laties, V.G. Enhancement of human performance by caffeine and the amphetamines.Pharmacol. Rev., 1962, 14, 1.

    PubMed  CAS  Google Scholar 

  • Wilson, M.C., and Schuster, C.R. Pharmacological modification of the self-administration of cocaine and SPA in the rhesus monkey. Reported to the NAS-NRC Committee on Problems of Drug Dependence, 1968.

    Google Scholar 

  • Wilson, M.C., Hitomi, M., and Schuster, C.R. Further studies of the self-administration of psychomotor stimulants in the rhesus monkey. Reported to the Committee on Problems ofDrug Dependence, 1969.

    Google Scholar 

  • Woods, J.H., and Schuster, C.R. Reinforcement properties of morphine, cocaine, and SPA as a function of unit dose. The International Journal of the Addictions, 1968, 3, 231.

    Google Scholar 

  • Yanagita, T., Deneau, G.A., and Seevers, M.H. Evaluation of pharmacologic agents in the monkey by long term intravenous self or programmed administration. Excerpta Medica International Congress Series, 1965, 87, 453.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Pickens, R., Thompson, T. (1971). Characteristics of Stimulant Drug Reinforcement. In: Thompson, T., Pickens, R. (eds) Stimulus Properties of Drugs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0788-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0788-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0790-8

  • Online ISBN: 978-1-4757-0788-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics