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Colon pp 17–44Cite as

Absorption and Secretion of Electrolytes by the Human Colon

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Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

An understanding of colonic function has developed more slowly than that of the stomach or small intestine. Although the recognition that the colon is “dispensable” in man no doubt contributed to this neglect, study of the colon in vivo has not been easy. Among the difficulties encountered are (1) a motor activity which is complex, which surely has important effects on absorption, but which is characterized poorly; (2) the existence in the large bowel of regions which differ in function; and (3) the billions of resident microorganisms whose identity and interrelationship with the host are unclear. However, it is clear that the metabolic actions of fecal flora modify colonic function in several important ways.

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References

  1. Phillis JW: Functions of the gastrointestinal tract, in Phillis JW (ed): Veterinary Physiology. Philadelphia, WB Saunders Co, 1976, pp. 401–415.

    Google Scholar 

  2. Stevens CE: Comparative physiology of the digestive system; in Swenson MJ (ed): Duke’s Physiology of Domestic Animals, 9. Ithaca, NY, Cornell University Press, 1977, pp. 216–232.

    Google Scholar 

  3. Garry RC: The movements of the large intestine. Physiol Rev 4:103–132, 1934.

    Google Scholar 

  4. Argenzio RA, Southworth M, Stevens CE: Sites of organic acid production and absorption in the equine gastrointestinal tract. Am J Physiol 226:1043–1050, 1974.

    PubMed  CAS  Google Scholar 

  5. Argenzio RA, Lowe JE, Pickard DW, et al: Digesta passage and water exchange in the equine large intestine. Am J Physiol 226:1035–1042, 1974.

    PubMed  CAS  Google Scholar 

  6. Christensen J: Colonic motility, Duthie HL (ed): in Gastrointestinal Motility in Health and Disease. MTP Press Ltd, 1978, pp. 367–377.

    Google Scholar 

  7. Schultz SG, Zalusky R: Ion transport in isolated rabbit ileum. I. Short circuit current and Na fluxes. J Gen Physiol 47:567–583, 1964.

    PubMed  CAS  Google Scholar 

  8. Ussing HH, Zerahn K: Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand 23:110–127, 1951.

    PubMed  CAS  Google Scholar 

  9. Powell DW: Transport in the large intestine, Giebisch G, Tosteson DC, Ussing HH (eds): in Membrane Transport in Biology. New York, Springer-Verlag New York Inc, 1978, pp. 781–809.

    Google Scholar 

  10. Parsons DS, Paterson CR: Fluid and solute transport across rat colonic mucosa. Q J Exp Physiol 50:220–231, 1965.

    CAS  Google Scholar 

  11. Parsons DS, Powis G: Some properties of a preparation of rat colon perfused in vitro through the vascular bed. J. Physiol 217:641–663, 1971.

    PubMed  CAS  Google Scholar 

  12. Parsons DS: Methods for investigation of intestinal absorption, in Code CF (ed): Handbook of Physiology: Section 6. Alimentary Canal, vol. 3, Intestinal Absorption. Washington, DC, American Physiological Society, 1968, pp. 1177–1216.

    Google Scholar 

  13. Diamond JM: Tight and leaky junctions of epithelia: A perspective on kisses in the dark. Fed Proc 33:2220–2224, 1974.

    PubMed  CAS  Google Scholar 

  14. Billich CO, Levitan R: Effect of sodium concentration and osmolality on water and electrolyte absorption from the intact human colon. J Clin Invest 48:1336–1347, 1969.

    PubMed  CAS  Google Scholar 

  15. Fordtran JS, Rector FC, Ewton MF, et al: Permeability characteristics of the human small intestine. J Clin Invest 44:1935–1944, 1965.

    PubMed  CAS  Google Scholar 

  16. Chadwick VS, Phillips SF, Hofmann AF: Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400) I. Chemical analysis and biological properties of PEG 400. Gastroenterology 73:241–246, 1977.

    PubMed  CAS  Google Scholar 

  17. Geall MG, Spencer RJ, Phillips SF: Transmural electrical potential difference of the human colon. Gut 10:921–923, 1969.

    PubMed  CAS  Google Scholar 

  18. Edmonds CJ: Electrical potential difference of colonic mucosa. Gut 16:315–318, 1975.

    PubMed  CAS  Google Scholar 

  19. Barry RJC: Electrical changes in relation to transport. Br Med Bull 23:266–269, 1967.

    PubMed  CAS  Google Scholar 

  20. Edmonds CJ, Richard P: Measurement of rectal electrical potential difference as an instant screening test for hyperaldosteronism. Lancet 2:624–627, 1970.

    PubMed  CAS  Google Scholar 

  21. Edmonds CJ, Pilcher D: Electrical potential difference and sodium and potassium fluxes across rectal mucosa in ulcerative colitis. Gut 14:784–789, 1973.

    PubMed  CAS  Google Scholar 

  22. Edmonds CJ: Electrical potentials of the sigmoid colon and rectum in irritable bowel syndrome and ulcerative colitis. Gut 11:867–874, 1970.

    PubMed  CAS  Google Scholar 

  23. Rask-Madsen J, Brix Jensen P: Electrolyte transport capacity and electrical potentials of the normal and the inflamed human rectum in vivo. Scand J Gastroenterol 8:169–175, 1973.

    PubMed  CAS  Google Scholar 

  24. Levitan R, Fordtran JS, Burrows B A, et al: Water and salt absorption in the human colon. J Clin Invest 41:1754–1759, 1962.

    PubMed  CAS  Google Scholar 

  25. Devroede GJ, Phillips SF, Code CF, et al: Regional differences in rates of insorption of sodium and water from the human large intestine. Can J Physiol Pharmacol 49:1023–1029, 1971.

    PubMed  CAS  Google Scholar 

  26. Gazet JC: The surgical significance of the ileo-caecal junction. Ann R Coll Surg Engl 43:19–38, 1968.

    PubMed  CAS  Google Scholar 

  27. Frizzell RA, Schultz SG: Models of electrolyte absorption and secretion by gastrointestinal epithelia, Crane RK (ed): in Gastrointestinal Physiology III, International Review of Physiology, Baltimore, University Park Press, 1979, pp. 205–225.

    Google Scholar 

  28. Binder HJ, Rawlins CL: Electrolyte transport across isolated large intestinal mucosa. Am J Physiol 225:1232–1239, 1973.

    PubMed  CAS  Google Scholar 

  29. Stoebel DP, Goldner AM: Ion transport across the rat colon abstracted. Physiologist 18:410, 1975.

    Google Scholar 

  30. Grady GF, Duhamel RC, Moore EW: Active transport of sodium by human colon in vitro. Gastroenterology 59:583–588, 1970.

    PubMed  CAS  Google Scholar 

  31. Archampong EQ, Harris J, Clark CG: The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro. Gut 13:880–886, 1972.

    PubMed  CAS  Google Scholar 

  32. Hawker PC, Mashiter KE, Turnberg LA: Mechanisms of transport of Na, Cl, and K in the human colon. Gastroenterology 74:1241–1247, 1978.

    PubMed  CAS  Google Scholar 

  33. Frizzell RA, Koch MJ, Schultz SG: Ion transport by rabbit colon. I. Active and passive components. J Membr Biol 27:297–316, 1976.

    PubMed  CAS  Google Scholar 

  34. Schultz SG, Frizzell RA, Nellans HN: Active sodium transport and the electrophysiology of rabbit colon. J Membr Biol 33:351–384, 1977.

    PubMed  CAS  Google Scholar 

  35. Schultz SG, Zalusky R: Interactions between active sodium transport and active amino-acid transport in isolated rabbit ileum. Nature (London) 205:292–294, 1965.

    CAS  Google Scholar 

  36. Schultz SG, Zalusky R: Ion transport in isolated rabbit ileum. II. The interaction between active sodium and active sugar transport. J Gen Physiol 47:1043–1059, 1964.

    PubMed  CAS  Google Scholar 

  37. Frizzell RA, Schultz SG: Effect of aldosterone on ion transport by rabbit colon in vitro. J Membr Biol 39:1–26, 1978.

    PubMed  CAS  Google Scholar 

  38. Frizzell RA, Turnheim K: Ion transport by rabbit colon. II, Unidirectional sodium influx and the effects of amphotericin B and amiloride. J Membr Biol 40:193–211, 1978.

    PubMed  CAS  Google Scholar 

  39. Carter MJ, Parsons DS: The isoenzymes of carbonic anhydrase: Tissue, subscellular distribution and functional significance, with particular reference to the intestinal tract. J Physiol 215:71–94, 1971.

    PubMed  CAS  Google Scholar 

  40. Phillips SF, Schmalz PF: Bicarbonate secretion by the rat colon: Effect of intraluminal chloride and acetazolamide. Proc Soc Exp Biol Med 135:116–122, 1970.

    PubMed  CAS  Google Scholar 

  41. Hubel KA: The ins and outs of bicarbonate in the alimentary tract. Gastroenterology 54:647–651, 1968.

    PubMed  CAS  Google Scholar 

  42. Hubel KA: The mechanism of bicarbonate secretion in rabbit ileum exposed to choleragen. J Clin Invest 53:964–970, 1974.

    PubMed  CAS  Google Scholar 

  43. Basti C, Kliger AS, Binder HJ, et al: Characteristics of potassium secretion in the mammalian colon. Am J Physiol 234(1):F48–53,1978.

    Google Scholar 

  44. Edmonds CJ, Nielsen OE: Transmembrane electrical potential differences and ionic composition of mucosal cells of rat colon. Acta Physiol Scand 72:338–349, 1968.

    PubMed  CAS  Google Scholar 

  45. Dawson AM, Holdsworth CD, Webb J: Absorption of short chain fatty acids in man. Proc Soc Exp Biol Med 117:97–100, 1964.

    PubMed  CAS  Google Scholar 

  46. Rubinstein R, Howard AV, Wrong OM: In vivo dialysis of faeces as a method of stool analysis. IV. The organic anion component. Clin Sci 37:549–564, 1969.

    PubMed  CAS  Google Scholar 

  47. Bjork JT, Soergel KH, Wood CM: The composition of “free” stool water, abstract ed. Gastroenterology 70:864, 1976.

    Google Scholar 

  48. Bustos-Fernandez L, Gonzales E, Marzi A, et al: Fecal acidorrhea. N Engl J Med 284:295–298, 1971.

    PubMed  CAS  Google Scholar 

  49. Torres-Pinedo R, Conde E, Robillard G, et al: Studies on infantile diarrhea. III. Changes in composition of saline and glucose-saline solutions instilled into the colon. Pediatrics 42:303–311, 1968.

    PubMed  CAS  Google Scholar 

  50. Fordtran JS: Organic anions in fecal contents. N Engl J Med 284:329–330, 1971.

    PubMed  CAS  Google Scholar 

  51. Argenzio RA, Miller N, von Engelhardt W: Effect of volatile fatty acids on water and ion absorption from the goat colon. Am J Physiol 229(4):997–1002, 1975.

    PubMed  CAS  Google Scholar 

  52. Argenzio RA, Southworth M, Stevens CE: Sites of organic acid production and absorption in the equine gastrointestinal tract. Am J Physiol 226(5): 1043–1050, 1974.

    PubMed  CAS  Google Scholar 

  53. Argenzio RA, Southworth M: Sites of organic acid production and absorption in the gastrointestinal tract of the pig. Am J Physiol 228(2):454–460, 1975.

    PubMed  CAS  Google Scholar 

  54. Yang MG, Manoharan K, Mickelsen O: Nutritional contribution of volatile fatty acids from the cecum of rats. J Nutr 100:545–550, 1970.

    PubMed  CAS  Google Scholar 

  55. Henning SJ, Hird FJR: Transport of acetate and butyrate in the hind-gut of rabbits. Biochem J 130:791–796, 1972.

    PubMed  CAS  Google Scholar 

  56. McNeil NI, Cummings JH, James WPT: Short chain fatty acid absorption by the human large intestine. Gut 19:819–822, 1978.

    PubMed  CAS  Google Scholar 

  57. Ruppin H, Bar-Meir S, Soergel KH, et al: Absorption of short-chain fatty acids by the colon. Gastroenterology 78:1500–1507, 1980.

    PubMed  CAS  Google Scholar 

  58. Bergman EN, Reid RS, Murray MG, et al: Interconversions and production of volatile fatty acids in the sheep rumen. Biochem J 97:53–58, 1965.

    PubMed  CAS  Google Scholar 

  59. Cummings JH: Short-chain fatty acids in the human colon. Gut 22:763–769, 1981.

    PubMed  CAS  Google Scholar 

  60. Argenzio RA, Whipp SC: Interrelationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig. J Physiol 295:365–381, 1979.

    PubMed  CAS  Google Scholar 

  61. Umesaki Y, Yajima T, Yokokura T, et al: Effect of organic acid absorption on bicarbonate transport in rat colon. Pflugers Arch 379:43–47, 1979.

    PubMed  CAS  Google Scholar 

  62. Argenzio RA, Southworth M, Lowe JE et al: Interrelationship of Na, HCO3 and volatile fatty acid transport by equine large intestine. Am J Physiol 233(6):E469–478, 1977.

    PubMed  CAS  Google Scholar 

  63. Henning SJ, Hird FJR: Ketogenesis from butyrate and acetate by the cecum and the colon of rabbits. Biochem J 130:785–790, 1972.

    PubMed  CAS  Google Scholar 

  64. Soergel KH, Goerg KJ, Wood CM: Propionate transport and metabolism by the short-circuited rat colon mucosa, abstracted. Clin Res 28:486A, 1980.

    Google Scholar 

  65. Field M: Intestinal secretion: Effect of cyclic AMP and its role in cholera. N Engl J Med 284:1137–1144, 1971.

    CAS  Google Scholar 

  66. Hendrix TR, Bayless RM: Digestion: Intestinal secretion. Ann Rev Physiol 32:139–164, 1970.

    CAS  Google Scholar 

  67. Ammon HV, Phillips SF: Inhibition of colonic water and electrolyte absorption by fatty acids in man. Gastroenterology 65:744–749, 1973.

    PubMed  CAS  Google Scholar 

  68. Bright-Asare P, Binder HJ: Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids. Gastroenterology 64:81–88, 1973.

    PubMed  CAS  Google Scholar 

  69. Racusen LC, Binder HJ: Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. J Clin Invest 63:743–749, 1979.

    PubMed  CAS  Google Scholar 

  70. Ewe K, Holker B: Einfluss eines diphenolischen Laxans (Bisacodyl) auf den Wasser- und Elektrolyttransport im menschlichen Colon. Klin Wochenschr 52:827–833, 1974.

    PubMed  CAS  Google Scholar 

  71. Donowitz M, Binder HJ: Effect of dioctyl sodium sulfosuccinate on structure and function of rodent and human intestine. Gastroenterology 69:941–950, 1975.

    PubMed  CAS  Google Scholar 

  72. Saunders DR, Sillery J. Rachmilewitz D: Effect of dioctyl sodium sulfosuccinate on structure and function of rodent and human intestine. Gastroenterology 69:380–386, 1975.

    PubMed  CAS  Google Scholar 

  73. Mekhjian HS, Phillips SF, Hofmann AF: Colonic secretion of water and electrolytes induced by bile acids: Perfusion studies in man. J Clin Invest 50:1569–1577, 1971.

    CAS  Google Scholar 

  74. Mekhjian HS, Phillips SF: Perfusion of the canine colon with unconjugated bile acids. Effect on water and electrolyte transport, morphology and bile acid absorption. Gastroenterology 59:120–129, 1970.

    PubMed  CAS  Google Scholar 

  75. Binder HJ, Rawlins CL: Effect of conjugated dihydroxy bile salts on electrolyte transport in rat colon. J Clin Invest 52:1460–1466, 1973.

    PubMed  CAS  Google Scholar 

  76. Wu ZC, O’Dorisio TM, Cataland S, et al: Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transport in vivo. Dig Dis Sci 24:625–630, 1979.

    PubMed  CAS  Google Scholar 

  77. Racusen LC, Binder HJ: Alteration of large intestinal electrolyte transport by vasoactive intestinal polypeptide in the rat. Gastroenterology 73:790–796, 1977.

    PubMed  CAS  Google Scholar 

  78. Krejs GJ: Effect of VIP infusion on water and ion transport in the human large intestine, abstracted. Gastroenterology 78:1200, 1980.

    Google Scholar 

  79. Donowitz M, Binder HJ: Effect of enterotoxins on Vibrio cholerae, Escherichia coli and Shigella dysenteriae Type 1 on fluid and electrolyte transport in the colon. J Infect Dis 134:135–143, 1976.

    PubMed  CAS  Google Scholar 

  80. Frizzell RA, Heintze K: Electrogenic chloride secretion by mammalian colon, in Binder HJ (ed): Mechanisms of Intestinal Secretion, New York, Alan R. Liss Inc, 1979, pp. 101–110.

    Google Scholar 

  81. Racusen LC, Binder HJ: Effect of prostaglandin on ion transport across isolated colonic mucosa. Dig Dis Sci 25:900–904, 1980.

    PubMed  CAS  Google Scholar 

  82. Frizzell RA: Active chloride secretion by rabbit colon: Calcium-dependent stimulation by ionophore A23187. J Membr Biol 35:175–187, 1977.

    PubMed  CAS  Google Scholar 

  83. Simon B, Czygan P, Spaan G et al: Hormone-sensitive adenylate cyclase in human colonic tissue. Digestion 17:229–233, 1978.

    PubMed  CAS  Google Scholar 

  84. Kimberg DV, Field M, Gershon E, et al: Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin. J Clin Invest 53:941–949, 1974.

    PubMed  CAS  Google Scholar 

  85. Buebler E, Juan H: Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin release by the rat colon. J Pharm Pharmacol 31:681–685, 1979.

    Google Scholar 

  86. Rachmilewitz D, Karmeli F: Effect of bisacodyl (BIS) and dioctyl sodium sulfosuccinate (DSS) on rat intestinal prostaglandin E2 (PGE2) content, Na-K-ATPase and adenyl cyclase activities, abstracted. Gastroenterology 76:1221, 1979.

    Google Scholar 

  87. Whalen GE, Harris JA, Greenen JE, et al: Sodium and water absorption from the human small intestine. The accuracy of the perfusion method. Gastroenterology 51:975–984, 1966.

    PubMed  CAS  Google Scholar 

  88. Phillips SF, Giller J: The contribution of the colon to electrolyte and water conservation in man. J Lab Clin Med 81:733–746, 1973.

    PubMed  CAS  Google Scholar 

  89. Holmberg C, Perheentupa J, Launiala K: Colonic electrolyte transport in health and in congenital chloride diarrhea. J Clin Invest 56:302–310, 1975.

    PubMed  CAS  Google Scholar 

  90. Debongnie JC, Phillips SF: Capacity of the human colon to absorb fluid. Gastroenterology 74:698–703, 1978.

    PubMed  CAS  Google Scholar 

  91. Milton-Thompson GJ, Cummings JH, Newman A, et al: Colonic and small intestinal response to intravenous prostaglandin F and E2 in man. Gut 16:42–46, 1975.

    PubMed  CAS  Google Scholar 

  92. Devroede GJ, Phillips SF: Studies of the perfusion technique for colonic absorption. Gastroenterology 56:92–100, 1969.

    PubMed  CAS  Google Scholar 

  93. Devroede GJ, Phillips SF: Conservation of sodium, chloride, and water by the human colon. Gastroenterology 56:101–109, 1969.

    PubMed  CAS  Google Scholar 

  94. Giller J, Phillips SF: Electrolyte absorption and secretion in the human colon. Am J Dig Dis 17:1003–1011, 1972.

    PubMed  CAS  Google Scholar 

  95. Fordtran JS, Rector FC, Carter NW: The mechanisms of sodium absorption in the human small intestine. J Clin Invest 47:884–900, 1968.

    PubMed  CAS  Google Scholar 

  96. Stamey TA: The pathogenesis and implications of the electrolyte imbalance in ureterosigmoidostomy. Surg Gynecol Obstet 103:736–758, 1956.

    PubMed  CAS  Google Scholar 

  97. Salas-Coll CA, Kermode JC, Edmonds CJ: Potassium transport across the distal colon in man. Clin Sci Mol Med 51:287–296, 1976.

    PubMed  CAS  Google Scholar 

  98. Wrong O, Metcalfe-Gibson A, Morrison RBI, et al: In vivo dialysis of faeces as a method of stool analysis. I. Technique and results in normal subjects. Clin Sci 28:357–375, 1965.

    PubMed  CAS  Google Scholar 

  99. Crane CW: Observations on the sodium and potassium content of mucus from the large intestine. Gut 6:439–443, 1965.

    PubMed  CAS  Google Scholar 

  100. Edmonds CJ: Kinetics of potassium in colonic mucosa of normal and sodium-depleted rats. J Physiol 203:533–554, 1969.

    PubMed  CAS  Google Scholar 

  101. Holloway WD, Tasman-Jones C, Lee SP: Digestion of certain fractions of dietary fiber in humans. Am J Clin Nutr 31:927–930, 1978.

    PubMed  CAS  Google Scholar 

  102. Raymond WF: The nutritive value of forage crops, Brady NC (ed): in Advances in Agronomy, Academic Press Inc, New York, 1969, vol 21, pp. 1–108.

    Google Scholar 

  103. Milton-Thompson GJ, Lewis B: The breakdown of dietary cellulose in man. Gut 12:853–854, 1971.

    PubMed  CAS  Google Scholar 

  104. Cummings JH, Southgate DAT, Branch WJ, et al: The digestion of pectin in the human gut and its effect on calcium absorption and large bowel function. Br J Nutr 41:477–485, 1979.

    PubMed  CAS  Google Scholar 

  105. Southgate DAT, Durnin JVGA: Calorie conversion factors. An experimental reassessment of the factors used in the calculation of the energy value of human diets. Br J Nutr 24:517–535, 1970.

    PubMed  CAS  Google Scholar 

  106. Eastwood MA, Mitchell WD: Physical properties of fiber: A biological evaluation, in Spiller GA, Amen RJ (eds): Fiber in Human Nutrition, New York, Plenum Press, 1976, pp. 109–129.

    Google Scholar 

  107. McConnell AA, Eastwood MA, Mitchell WD: Physical characteristics of vegetable foodstuffs that could influence bowel function. J Sci Food Agric 25:1457–1464, 1974.

    PubMed  CAS  Google Scholar 

  108. Stephen AM, Cummings JH: Effect on dietary fiber on fecal bacterial mass, abstracted. Gut 20:A457–458, 1979.

    Google Scholar 

  109. Bond JH, Currier BE, Buchwald H, et al: Colonie conservation of malabsorbed carbohydrate. Gastroenterology 78:444–447, 1980.

    PubMed  CAS  Google Scholar 

  110. Bond JH, Levitt MD: Fate of soluble carbohydrate in the colon of rats and man. J Clin Invest 57:1158–1164, 1976.

    PubMed  CAS  Google Scholar 

  111. Bond JH, Engel RR, Levitt MD: Factors influencing pulmonary methane excretion in man. J Exp Med 133:572–588, 1971.

    PubMed  CAS  Google Scholar 

  112. Levitt MD, Donaldson RM: Use of respiratory hydrogen (H2) excretion to detect carbohydrate malabsorption. J Lab Clin Med 75:937–945, 1970.

    PubMed  CAS  Google Scholar 

  113. Walser M, Bodenloss LJ: Urea metabolism in man. J Clin Invest 38:1617–1626, 1959.

    PubMed  CAS  Google Scholar 

  114. Gibson JA, Sladen GE, Damson AM: Studies in the role of the colon in urea metabolism, abstracted. Gut 14:816, 1973.

    PubMed  CAS  Google Scholar 

  115. Wolpert E, Phillips SF, Summerskill WHJ: Transport of urea and ammonia production in the human colon. Lancet 2:1387–1390, 1971.

    PubMed  CAS  Google Scholar 

  116. Down PF, Agostini L, Murison J, et al: The interrelations of fecal ammonia, pH and bicarbonate: Evidence of colonic absorption of ammonia by nonionic diffusion. Clin Sci 43:101–114, 1972.

    PubMed  CAS  Google Scholar 

  117. Wolpert E, Phillips SF, Summerskill WHJ: Ammonia production in the human colon. Effects of cleansing, neomycin and acetohydroxamic acid. N Engl J Med 283:159–164, 1970.

    PubMed  CAS  Google Scholar 

  118. Bond JH, Levitt MD: Investigations of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med 85:546–555, 1975.

    PubMed  CAS  Google Scholar 

  119. Zeegen R, Drinkwater JE, Fenton JCB, et al: Some observations on the effects of treatment with lactulose on patients with chronic hepatic encephalopathy. Q J Med 39:245–263, 1970.

    PubMed  CAS  Google Scholar 

  120. Agostini L. Down PF, Murison J, et al: Fecal ammonia and pH during lactulose administration in man: Comparison with other cathartics. Gut 13:859–866, 1972.

    PubMed  CAS  Google Scholar 

  121. Vince A, Killingley M, Wrong OM: Effect of lactulose on ammonia production in a fecal incubation system. Gastroenterology 74:544–549, 1978.

    PubMed  CAS  Google Scholar 

  122. Niiyama M, Deguchi E, Kagota K, et al: Appearance of 15N-labeled intestinal microbial amino acids in the venous blood of the pig colon. Am J Vet Res 40:716–718, 1979.

    PubMed  CAS  Google Scholar 

  123. Conn HO, Lactulose: A drug in search of a modus operandi. Gastroenterology 74:624–626, 1978.

    PubMed  CAS  Google Scholar 

  124. Resnick RH, Gray S J: Distribution of serotonin (5-hydroxy tryptamine) in the human gastrointestinal tract. Gastroenterology 41:119–121, 1961.

    PubMed  CAS  Google Scholar 

  125. Deschner E: Argentaffin cell incidence in the rectal mucosa of man, mouse, and hamster. Nature (London) 207:873–874, 1965.

    CAS  Google Scholar 

  126. Cristina ML, Lehy T, Zeitoun P, et al: Fine structural classification and comparative distribution of endocrine cells in normal human large intestine. Gastroenterology 75:20–28, 1978.

    PubMed  CAS  Google Scholar 

  127. Knudsen JB, Holst JJ, Asnares S, et al: Identification of cells with pancreatic-type and gut-type glucagon immunoreactivity in the human colon. Acta Pathol Microbiol Scand 83A:741–743, 1975.

    Google Scholar 

  128. Polak JM, Bloom SR, McCrossan MV, et al: Distribution of somatostatin producing D cells in the human intestine, abstracted. Gastroenterology 72:822, 1977.

    Google Scholar 

  129. Moxey PC: Is the human colon an endocrine organ? Gastroenterology 75:147–149, 1978.

    PubMed  CAS  Google Scholar 

  130. Levitan R, Ingelfinger FJ: Effect of d-aldosterone on salt and water absorption from the intact human colon. J Clin Invest 44:801–808, 1965.

    PubMed  CAS  Google Scholar 

  131. Shields R, Mulholland AT, Elmslie RG: Action of aldosterone upon the intestinal transport of potassium, sodium, and water. Gut 7:686–696, 1966.

    PubMed  CAS  Google Scholar 

  132. Silva P, Charney AN, Epstein FH: Potassium adaptation and Na-K ATPase activity in mucosa of colon. Am J Physiol 6:1576–1579, 1975.

    Google Scholar 

  133. Fisher KA, Binder HJ, Hayslett JP: Potassium secretion by colonic mucosal cells after potassium adaptation. Am J Physiol 231:987–994, 1976.

    PubMed  CAS  Google Scholar 

  134. Edmonds CJ, Marriott JC: The effect of adolsterone and adrenalectomy on the electrical potential difference of rat colon and on the transport of sodium, potassium, chloride and bicarbonate. J Endocrinol 39:517–531, 1967.

    PubMed  CAS  Google Scholar 

  135. Dolman D, Edmonds CJ: The effect of adolsterone and the renin-angiotensin system on sodium, potassium and chloride transport by proximal and distal rat colon in vivo. J Physiol 250:597–611, 1975.

    PubMed  CAS  Google Scholar 

  136. Field M: Corticosteroids, Na, K-ATPase and intestinal water and electrolyte transport. Gastroenterology 75:317–319, 1978.

    PubMed  CAS  Google Scholar 

  137. Charney AN, Silvia P, Besarab A, et al: Separate effects of aldosterone, DOCA, and methylprednisolone on renal Na-K-ATPase. Am J Physiol 227:345–350, 1974.

    PubMed  CAS  Google Scholar 

  138. Binder HJ: Effect of dexamethasone on electrolyte transport in the large intestine of the rat. Gastroenterology 75:212–217, 1978.

    PubMed  CAS  Google Scholar 

  139. Levitan R, Mauer I: Effect of intravenous antidiuretic hormone administration on salt and water absorption from the human colon. J Lab Clin Med 72:739–746, 1968.

    PubMed  CAS  Google Scholar 

  140. Soergel KH, Whalen GE, Harris JA, et al: Effect of antidiuretic hormone on human small intestinal water and solute transport. J Clin Invest 47:1071–1082, 1968.

    PubMed  CAS  Google Scholar 

  141. Aulsebrook KA: Effect of vasopressin on sodium transfer by rat colon in vitro. Endocrinology 68:1063–1065, 1961.

    PubMed  CAS  Google Scholar 

  142. Bloom SR, Polak JM, Pearse AGE: Vasoactive intestinal peptide and watery diarrhea syndrome. Lancet 2:14–16, 1973.

    PubMed  CAS  Google Scholar 

  143. Rambaud JC, Modigliani R, Matuchansky C, et al: Pancreatic cholera. Studies on tumoral secretions and pathophysiology of diarrhea. Gastroenterology 69:110–122, 1975.

    PubMed  CAS  Google Scholar 

  144. Binder HJ, Donowitz M: A new look at laxative action. Gastroenterology 69:1001–1005, 1975.

    PubMed  CAS  Google Scholar 

  145. Nell G, Overhoff H, Forth W, et al: The influence of water gradients and oxyphenisatin on the net transfer of sodium and water in the rat colon. Naunyn-Schmiedeberg’s Arch Pharmacol 277:363–372, 1973.

    CAS  Google Scholar 

  146. Ewe K: Effect of laxatives on intestinal water and electrolyte transport, abstracted. Eur J Clin Invest 2:283, 1972.

    Google Scholar 

  147. Saunders DR, Sillery J, Surawicz C, et al: Effect of Phenolphthalein on the function and structure of rodent and human intestine. Dig Dis Sci 23:909–913, 1978.

    CAS  Google Scholar 

  148. Gaginella TS, Phillips SF: Ricinoleic acid (castor oil) alters intestinal surface structure: A scanning electron microscopic study. Mayo Clin Proc 51:6–12, 1976.

    PubMed  CAS  Google Scholar 

  149. Gaginella TS, Chadwick VS, Debongnie JC et al: Perfusion of rabbit colon with ricinoleic acid: Dose-related mucosal injury, fluid secretion and increased permeability. Gastroenterology 73:95–101, 1977.

    PubMed  CAS  Google Scholar 

  150. Rachmilewitz D, Karmeli F, Okon E: Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine. Dig Dis Sci 25:602–608, 1980.

    PubMed  CAS  Google Scholar 

  151. Conley DR, Coyne MJ, Bonorris GG, et al: Bile acid stimulation of colonic adenylate cyclase and secretion in the rabbit. Am J Dig Dis 21:453–458, 1976.

    PubMed  CAS  Google Scholar 

  152. Conley D, Coyne MJ, Chung A, et al: Propranolol inhibits adenylate cyclase and secretion stimulated by deoxycholic acid in the rabbit colon. Gastroenterology 71:72–75, 1976.

    PubMed  CAS  Google Scholar 

  153. Chadwick VS, Gaginella TS, Carlson GL, et al: Effect of molecular structure on bile acid induced alterations in absorptive function, permeability, and morphology in perfused rabbit colon. J Lab Clin Med 94:661–674, 1979.

    PubMed  CAS  Google Scholar 

  154. Gordon SJ, Kinsey MD, Magen JS, et al: Structure of bile acids associated with secretion in the rat cecum. Gastroenterology 77:38–44, 1979.

    PubMed  CAS  Google Scholar 

  155. Thomas PJ: Identification of some enteric bacteria which convert oleic acid to hydroxystearic acid in vitro. Gastroenterology 62:430–435, 1972.

    PubMed  CAS  Google Scholar 

  156. Ammon HV, Thomas PJ, Phillips SF: Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. J Clin Invest 53:374–379, 1974.

    PubMed  CAS  Google Scholar 

  157. Ammon HV, Phillips SF: Inhibition of ileal water absorption by intraluminal fatty acids. J Clin Invest 53:205–210, 1974.

    PubMed  CAS  Google Scholar 

  158. Gaginella TS, Stewart JJ, Gullikson GW et al: Inhibition of small intestinal mucosal and smooth muscle cell function by ricinoleic acid and other surfactants. Life Sci 16:1595–1606, 1975.

    PubMed  CAS  Google Scholar 

  159. Binder HJ, Filburn C, Volpe BT: Bile salt alteration of colonic electrolyte transport: Role of cyclic adenosine monophosphate. Gastroenterology 68:503–508, 1975.

    PubMed  CAS  Google Scholar 

  160. Taub M, Bonorris G, Chung A, et al: Effect of propranolol on bile acid and cholera enterotoxin stimulated cAMP and secretion in rabbit intestine. Gastroenterology 72:101–105, 1977.

    PubMed  CAS  Google Scholar 

  161. Coyne MJ, Bonorris GG, Chung A, et al: Propranolol inhibits bile acid and fatty acid stimulation of cyclic AMP in human colon. Gastroenterology 73:971–974, 1977.

    PubMed  CAS  Google Scholar 

  162. Donowitz M, Charney AN: No effect of propranolol on chronic diarrhea, correspondence. N Engl J Med 300:201, 1979.

    PubMed  CAS  Google Scholar 

  163. Binder HJ, Dobbons JW, Racusen LC et al: Effect of propranolol on ricinoleic acid and deoxycholic acid induced changes of intestinal electrolyte movement and mucosal permeability. Gastroenterology 75:668–673, 1978.

    PubMed  CAS  Google Scholar 

  164. Phillips SF, Gaginella TS: Effects of fatty acids and bile acids on intestinal water and electrolyte transport, in Binder HJ (ed): Mechanisms of Intestinal Secretion, New York, Alan R. Liss Inc, 1979, pp. 287–294.

    Google Scholar 

  165. Phillips SF, Gaginella TS: Intestinal secretion as a mechanism in diarrheal disease, in Jerzy Glass GB (ed): Progress in Gastroenterology, New York, Grime & Stratton, 1977, vol 3, pp. 481–504.

    Google Scholar 

  166. Pak CYC, Fordtran JS: Disorders of mineral metabolism, in Sleisenger MH, Fordtran JS, (eds): Gastrointestinal Disease, 2. ed. Philadelphia, WB Saunders Co, 1978, vol 1; pp. 251–271.

    Google Scholar 

  167. Petith MM, Schedl HP: Intestinal adaptation to dietary calcium restriction: In vivo cecal and colonic calcium transport in the rat. Gastroenterology 71:1039–1042, 1976.

    PubMed  CAS  Google Scholar 

  168. Harrison HC, Harrison HE: Calcium transport by rat colon in vitro. Am J Physiol 217(1): 121–125, 1969.

    PubMed  CAS  Google Scholar 

  169. Wacker WEC, Parisi AF: Magnesium metabolism. N Engl J Med 278:658–663, 1968.

    PubMed  CAS  Google Scholar 

  170. Davies NT: Studies on the absorption of zinc by rat intestine. Br J Nutr 43:189–203, 1980.

    PubMed  CAS  Google Scholar 

  171. Banwell JG, Pierce NF, Mitra RC, et al: Intestinal fluid and electrolyte transport in human cholera. J Clin Invest 49:183–195, 1970.

    PubMed  CAS  Google Scholar 

  172. Hofmann AF, Poley JR: Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long-chain triglyceride by medium-chain triglyceride. Gastroenterology 62:918–934, 1972.

    PubMed  CAS  Google Scholar 

  173. Cummings JH, James WPT, Wiggins HS: Role of the colon in ileal-resection diarrhea. Lancet 1:344–347, 1973.

    PubMed  CAS  Google Scholar 

  174. Mitchell JE, Breuer RI, Zuckerman L, et al: The colon influences ileal resection diarrhea. Dig Dis Sci 25:33–41, 1980.

    PubMed  CAS  Google Scholar 

  175. Turnberg LA: Abnormalities in intestinal electrolyte transport in congenital chloridorrhoea. Gut 12:544–551, 1971.

    PubMed  CAS  Google Scholar 

  176. Harris J, Shields R: Absorption and secretion of water and electrolytes by the intact human colon in diffuse untreated proctocolitis. Gut 11:27–33, 1970.

    PubMed  CAS  Google Scholar 

  177. Duthie HL, Watts JM, De Dombal FT, et al: Serum electrolytes and colonic transfer of water and electrolytes in chronic ulcerative colitis. Gastroenterology 47:525–530, 1964.

    PubMed  CAS  Google Scholar 

  178. Rask-Madsen J, Hammersgaard EA, Knudsen E: Rectal electrolyte transport and mucosal permeability in ulcerative colitis and Crohn’s disease. J Lab Clin Med 81:342–353, 1973.

    PubMed  CAS  Google Scholar 

  179. Levitan R, Bikerman V, Burrows BA, et al: Rectosigmoidal absorption of phenolsulfonphthalein (PSP), sulfisoxazole diethanolamine (Gantrisin), and radioiodine (I131) in normal subjects and patients with idiopathic ulcerative colitis. J Lab Clin Med 62:639–645, 1963.

    PubMed  CAS  Google Scholar 

  180. Head LH, Heaton JW, Kivel RM; Absorption of water and electrolytes in Crohn’s disease of the colon. Gastroenterology 56:571–579, 1969.

    PubMed  CAS  Google Scholar 

  181. Sharon P, Ligumsky M, Rachmilewitz D, et al: Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75:638–640, 1978.

    PubMed  CAS  Google Scholar 

  182. Rampton DS, Sladen GE, Bhakoo KK, et al: Rectal mucosal prostaglandin E release and electrolyte transport in ulcerative colitis, in Samuelsson B, Ramwell PW, Paoletti R (eds): Advances in Prostaglandin and Thromboxane Research, New York, Raven Press, 1980, vol 8, pp. 1621–1625.

    Google Scholar 

  183. Keusch GT: Ecological control of the bacterial diarrheas: A scientific strategy. Am J Clin Nutr 31:2208–2218, 1978.

    PubMed  CAS  Google Scholar 

  184. Keusch GT: Shigellosis control—A rosy future? J Infect Dis 136:456–457, 1977.

    Google Scholar 

  185. Gianella RA, Gots RE, Charney AN, et al: Pathogenesis of salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin. Gastroenterology 69:1238–1245, 1975.

    Google Scholar 

  186. Giannella RA: Importance of the intestinal inflammatory reaction in salmonella-mediated intestinal secretion. Infect Immun 23:140–145, 1979.

    PubMed  CAS  Google Scholar 

  187. Rout WR, Formal SB, Dammin GJ, et al: Pathophysiology of salmonella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies. Gastroenterology 67:59–70, 1974.

    PubMed  CAS  Google Scholar 

  188. Shields R: Absorption and secretion of electrolytes and water by the human colon, with particular reference to benign adenoma and papilloma. Br J Surg 53:893–897, 1966.

    PubMed  CAS  Google Scholar 

  189. Salem AA, Prokipchuk EJ, Hendrix TR: Fecal electrolyte loss in villous adenoma of the colon: Its alteration by salt depletion. Bull Johns Hopkins Hosp 117:69–74, 1965.

    Google Scholar 

  190. Devroede G, Soffie M: Colonie absorption in idiopathic constipation. Gastroenterology 64:552–561, 1973.

    PubMed  CAS  Google Scholar 

  191. Dobbins JW, Binder HJ: Derangements of oxalate metabolism in gastrointestinal disease and their mechanisms, in Jerzy Glass GB (ed):Progress in Gastroenterology, New York, Grune & Stratton, Inc, 1977, vol 3, pp. 505–518.

    Google Scholar 

  192. Dobbins JW, Binder HJ: Importance of the colon in enteric hyperoxaluria. N Engl J Med 296:298–301, 1977.

    PubMed  CAS  Google Scholar 

  193. Morris AI, Turnberg LA: Surreptitious laxative abuse. Gastroenterology 77:780–786, 1979.

    PubMed  CAS  Google Scholar 

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Kerlin, P., Phillips, S. (1983). Absorption and Secretion of Electrolytes by the Human Colon. In: Bustos-Fernández, L. (eds) Colon. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0307-8_2

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