Abstract
The corpus striatum contains a massive cholinergic innervation which is mainly of intrinsic origin. Evidence has been provided that striatal acetylcholine (ACh) (inter)neurons may be regulated by the afferent nigrostriatal dopaminergic (13, 25) and raphe-striatal serotonergic pathways (5). Little is known, however, of a possible regulation of cholinergic neurons by GABA. Previous studies with Picrotoxin have suggested that GABA may affect the activity of cholinergic neurons indirectly via changes in the activity of the nigrostriatal dopaminergic pathway (10,12). Recent data obtained in our laboratory have also indicated the existence of a GABA-mediated inhibitory influence on cholinergic cells which is intrinsic to the striatum (17 18, 20). The present report reviews the available evidence for, and analyzes the possible functional implications of, this intrastriatal GABA-ACh link.
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© 1981 Plenum Press, New York
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Scatton, B., Bartholini, G. (1981). Gaba-Acetylcholine Interaction in the Rat Striatum. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_76
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DOI: https://doi.org/10.1007/978-1-4684-8643-8_76
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