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Mapping of Cholinergic Systems in Rostral Forebrain of the Rodent

  • Chapter
Cholinergic Mechanisms

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

Visualization of central cholinergic system has been hampered by technical difficulties. No suitable method is. yet available for the visualization of acetylcholine (ACh). The conventional histochemistry for acetylcholinesterase (AChE), as discussed in another chapter (9), is not a reliable marker for cholinergic neurons. Although the modified histochemistry for AChE has provided useful information (10) it is still not definitive for cholinergic perikarya nor applicable to the visualization of fibers and terminals. Several attempts have been made to visualize choline acetyltransferase (CAT), a specific marker enzyme for cholinergic systems in the CNS. A proposed histochemical method is not completely specific, since it is based on the precipitation of CaA which is produced not only by CAT but by several enzymes (2).

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Author information

Authors and Affiliations

  1. Kinsman Laboratory, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, British Columbia, Canada

    H. Kimura, P. L. McGeer, J. H. Peng & E. G. McGeer

Authors
  1. H. Kimura
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  2. P. L. McGeer
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  3. J. H. Peng
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  4. E. G. McGeer
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Kimura, H., McGeer, P.L., Peng, J.H., McGeer, E.G. (1981). Mapping of Cholinergic Systems in Rostral Forebrain of the Rodent. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_70

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_70

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

  • eBook Packages: Springer Book Archive

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