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Glial Plasminogen Activators in Developing and Regenerating Neural Tissue

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Serine Proteases and Their Serpin Inhibitors in the Nervous System

Part of the book series: NATO ASI Series ((NSSA,volume 191))

Abstract

In the following chapter I would like to introduce the postulate that a population of neural cells -- the glia -- serve as construction/remodelling agents in morphogenetic processes during development and regeneration of the nervous system. The capacity of these glial cells to perform their plasticity function effectively is dependent on their potential to generate extracellular proteolytic activities, namely, to produce plasminogen activator (PA) of the urokinase type (u-PA). Previously published and new data are being presented in support of this hypothesis.

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Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021, USA

    Nurit Kalderon

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  1. Nurit Kalderon
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, University of Kansas Medical Center, 64128, Kansas City, Missouri, USA

    Barry W. Festoff M.D. (Director) (Director)

  2. I.N.S.E.R.M., Unité 153, 75005, Paris, France

    Daniel Hantaï M.D., Ph.D.

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© 1990 Plenum Press, New York

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Kalderon, N. (1990). Glial Plasminogen Activators in Developing and Regenerating Neural Tissue. In: Festoff, B.W., Hantaï, D. (eds) Serine Proteases and Their Serpin Inhibitors in the Nervous System. NATO ASI Series, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8357-4_19

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  • DOI: https://doi.org/10.1007/978-1-4684-8357-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8359-8

  • Online ISBN: 978-1-4684-8357-4

  • eBook Packages: Springer Book Archive

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