Abstract
If plasma levels of antipsychotic drug could be related in some way to clinical outcome, the pharmacotherapy of schizophrenia might become less of a frontier profession. So far, all that appears to be firmly established is that plasma levels of antipsychotic drugs vary enormously between patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
P. R. A. May and T. Van Putten, Plasma and saliva levels of chlorpromazine in schizophrenia: a critical review of the literature. Arch. Gen. Psychiatr. 35:477, (1978).
J. M. Davis, S. Erickson and H. Dekirmenjian, Plasma levels of antipsychotic drugs and clinical response, in “Psychopharmacology: A Generation of Progress,” M. A. Lipton, A. DiMascio and K. F. Killam, eds., Raven, New York (1978).
M. W. Dysken, J. I. Javaid and S. S. Chang, Fluphenazine pharmacokinetics and therapeutic response, Psychopharmacology 73:205 (1981).
J. R. Magliozzi, L. E. Hollister, K. V. Arnold and G. M. Earle, Relationship of serum haloperidol levels to clinical response in schizophrenic patients, Am. J. Psychiatr. 138:365 (1981).
Extein, K. A. Augusthy and M. S. Gold, Plasma haloperidol levels and clinical response in acute schizophrenia, Psychopharm. Bull. 18:156 (1982).
R. C. Smith, What is the clinical value of a neuroleptic blood level? Presented at the American College of Neuropsycho-pharmacology, Dec. 17, 1981.
T. Van Putten, P. R. A. May, S. R. Marder, J. N. Wilkens and B. J. Rosenberg, Plasma levels of thiothixene by radioreceptor assays: clinical usefulness, Psychopharmacology 79:40 (1983).
T. Van Putten, P. R. A. May and D. J. Jenden, Does a plasma level of chlorpromazine help? Psychol. Med. 11:729 (1981).
P. R. A. May, T. Van Putten, D. J. Jenden, C. Yale, and W. J. Dixon, Chlorpromazine in blood and saliva levels and the outcome of treatment in schizophrenic patients, Arch. Gen. Psychiatr. 38, 202 (1981).
R. T. Ruben, A. Forsman and J. Heykantz, Serum haloperidol determinations in psychiatric patients: comparison of methods and correlation with serum prolactin, Arch. Gen. Psychiatr. 37:1069 (1980).
Creese, D. R. Burt and S. H. Snyder, A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood, Nature 270:180 (1977).
J. E. Overall and D. R. Gorham, The brief psychiatric rating scale, Psychol. Rep. 10:799 (1962).
G. Honigfeld and C. J. Klett, The nurses’ observation scale for inpatient evaluation: a new scale for measuring improvement in chronic schizophrenia J. Clin. Psychol. 21:65 (1965).
J. A. Yesavage, J. Becker and P. D. Werner, Serum level monitoring of thiothixine in schizophrenia: acute single-dose levels at fixed doses, Am. J. Psychiatr. 139:174 (1982).
L. Hollister, Plasma levels and the management of chronic refractory schizophrenics. Presented at VII World Congress of Psychiatry, Vienna, 12 July, 1983.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer Science+Business Media New York
About this chapter
Cite this chapter
Putten, T.V. (1985). Guidelines to use of Plasma Levels From a Clinical Perspective. In: Pichot, P., Berner, P., Wolf, R., Thau, K. (eds) Biological Psychiatry, Higher Nervous Activity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8329-1_74
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8329-1_74
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8331-4
Online ISBN: 978-1-4684-8329-1
eBook Packages: Springer Book Archive