Abstract
The effect of three platinum coordination complexes on wild type and repair deficient mutant of Escherichia coli has been investigated. The antitumor drug cis-platinum (II) diamminodichloride (cis-PDD) produces an inhibition of DNA synthesis and reduces the viability of excision repair and recombination defective mutants. The trans isomer (trans-PDD) has less effect than cis-PDD on all of these mutants while [Pt(dien)C1]C1 has no effect. Incorporation of radioactive precursors under non-replicating conditions and density gradient centrifugation analysis of DNA indicate that repair synthesis occurred after treatment of wild type cells with cis-PDD or trans-PDD.
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© 1981 Plenum Press, New York
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Alazard, R., Germanier, M. (1981). Effects of Platinum Coordination Complexes on Mutants of Escherichia coli Defective in DNA Repair and Genetic Recombination. In: Seeberg, E., Kleppe, K. (eds) Chromosome Damage and Repair. NATO Advanced Study Institutes Series, vol 40. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7956-0_61
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DOI: https://doi.org/10.1007/978-1-4684-7956-0_61
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