Abstract
Pancreatic cancer is the fifth leading cause of death due to cancer in the United States,1 yet thus far the only strong etiological association with this disease is cigarette smoking.2 Hence, research into preventative strategies not only provides practical applications to public health recommendations, but may elucidate carcinogenesis mechanisms.
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References
E. Silverberg and J.A. Lubera, Cancer statistics, 1989, CA-Cancer J Clin. 39: 3 (1989).
T.M. Mack, Pancreas, in: “Cancer Epidemiology and Prevention,” D. Schottenfeld and J. Fraumeni, eds., W.B. Sanders Company, Philadelphia (1982).
D.H. Garabrant, J.M. Peters, T.M. Mack, and L. Bernstein, Job activity and colon cancer risk, Am J Epidem. 119: 1005 (1984).
M. Gerhardsson, S.E. Norell, H. Kiviranta, N.L. Pedersen, and A. Ahlbom, Sedentary jobs and colon cancer, Am J Epidem. 123: 775 (1986).
J.E. Vena, S. Graham, M. Zielezny, J. Brasure, and M.K. Swanson, Occupational exercise and risk of cancer, Am J Clin Nutr. 45: 318 (1987).
E.R. Eichner, Exercise, lymphokines, calories, and cancer, The Physician and Sportsmedicine. 15: 109 (1987).
R.E. Frisch, G. Wyshak, N.L. Albright, T.E. Albright, I. Schiff, J. Witschi, and M. Marguglio, Lower lifetime occurence of breast cancer and cancers of the reproductive system among former college athletes, Am J Clin Nutr. 45: 328 (1987).
M.M. Gauthier, Can exercise reduce the risk of cancer?, The Physician and Sportsmedicine. 14: 171 (1986).
R. Ballard-Barbash, A. Schatzkin, D. Albanes, M.H. Schiffman, B.E. Kreger, W.B. Kannei, K.M. Anderson, and W.E. Helsel, Physical activity and risk of large bowel cancer in the Framingham study, Cancer Res. 50: 3610 (1990).
R.S. Paffenbarger Jr., R.T. Hyde, A.L. Wing, and C. Hsieh, Physical activity, all-cause mortality, and longevity of college alumni, N Engl J Med. 314: 605 (1986).
L. Garfinkel, and S.D. Stellman, Mortality by relative weight and exercise, Cancer. 62: 1844 (1988).
J.O. Holloszy, E.K. Smith, M. Vining, and S. Adams, Effect of voluntary exercise on longevity of rats, J Appl Physiol. 59: 826 (1985).
B.D. Roebuck, J.D. Yager, and D.S. Longnecker, Dietary modulation of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41: 888 (1981).
B.D. Roebuck, J.D. Yager, D.S. Longnecker, and S.A. Wilpone, Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41: 3961 (1981).
D.M. Klurfeld, C.B. Welch, M.J. Davis, and D. Kritchevsky, Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase, J Nutr. 119: 286 (1989).
L.A. Cohen, K. Choi, and C. Wang, Influence of dietary fat, caloric restriction, and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats, Cancer Res. 48: 4276 (1988).
B.D. Roebuck, J. McCaffrey, and K. Baumgartner, Protective effects of voluntary exercise during the postinitiation phase of pancreatic carcinogenesis in the rat, Cancer Res. 50: 6811 (1990).
B.S. Reddy, S. Sugie and A. Lowenfels, Effect of voluntary exercise on azoxymethane-induced colon carcinogenesis in male F344 rats, Cancer Res. 48: 7079 (1988).
H.J. Thompson, A.M. Ronan, K.A. Ritacco, A.R. Tagliaferro, and L.D. Meeker, Effect of exercise on the induction of mammary carcinogenesis, Cancer Res 48: 2720 (1988).
H.J. Thompson, A.M. Ronan, K.A. Ritacco, and A.R. Tagliaferro, Effect of type and amount of dietary fat on the enhancement of rat mammary tumorigenesis of exercise, Cancer Res. 49: 1904 (1989).
J.C. Russell, W.F. Epling, D. Pierce, R.M. Amy, and D.P. Boer, Induction of voluntary prolonged running by rats, J Appl Physiol. 63: 2549 (1987).
B.D. Roebuck, K.J. Baumgartner, and D.S. Longnecker, Growth of pancreatic foci and development of pancreatic cancer with a single dose of azaserine in the rat, Carcinogenesis. 8: 1831 (1987).
G. Bieri, Report of the American Institute of Nutrition ad hoc Committee on standards of nutritional studies, J Nutr. 107: 1340 (1977).
G. Bieri, Second report of the ad hoc committee on standards for nutritional studies, J Nutr. 110: 1726 (1980).
M.S. Rao, M.P. Upton, V. Subbarao, and D.G. Scarpelli, Two populations of cells with differing proliferative capacities in atypical acinar cell foci induced by 4-hydroxyaminoquinoline-1-oxide in the rat pancreas, Lab Invest. 46: 527 (1982).
B.D. Roebuck, K.J. Baumgartner, and C.D. Thron, Characterization of two populations of pancreatic atypical acinar cell foci induced by azaserine in the rat, Lab Invest. 50: 141 (1984).
T.D. Pugh, J.H. King, H. Koen, D. Nychka, J. Choyer, G. Wahba, Y. He, and S. Goldfarb, Reliable stereological method for estimating the number of microscopic hepatocellular foci from their transections, Cancer Res. 43: 1261 (1983).
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© 1992 Plenum Press, New York
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Giles, T.C., Roebuck, B.D. (1992). Effects of Voluntary Exercise and/or Food Restriction on Pancreatic Tumorigenesis in Male Rats. In: Jacobs, M.M. (eds) Exercise, Calories, Fat and Cancer. Advances in Experimental Medicine and Biology, vol 322. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7953-9_3
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DOI: https://doi.org/10.1007/978-1-4684-7953-9_3
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