Abstract
Gangliosides have been found in various organs and tissues, however they are localized in a rather high amount and with a great diversity in the central nervous system (see for review LEDEEN and YU, 1976). The synthesis of gangliosides occurs by different pathways, requiring glycosyltransferases and sialyltransferases. Activities of these enzymes were studied both in non-nervous and in nervous tissues, with respect to their subcellular localization and kinetic properties. It was postulated that sialic acid residues on cell surfaces are involved in membrane-related cellular phenomena such as cellular recognition and adhesion, malignant transformation, contact inhibition and cellular migration (see for review SCHAUER, 1973). Further sialosyl groups seem to be involved in the receptor function of gangliosides (YAMAKAWA and NAGAI, 1978). Moreover, it was hypothesized that the formation of an enzyme-substrate complex between a glycosyltransferase from one cell and one acceptor from another could be responsible for cellular recognition (ROSEMAN, 1970).
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© 1980 Plenum Press, New York
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Dreyfus, H., Harth, S., Yusufi, A.N.K., Urban, P.F., Mandel, P. (1980). Sialyltransferase Activities in Two Neuronal Models : Retina and Cultures of Isolated Neurons. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_22
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DOI: https://doi.org/10.1007/978-1-4684-7844-0_22
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