Skip to main content

Part of the book series: Basic Life Sciences ((BLSC,volume 57))

  • 50 Accesses

Abstract

Moderator (Ivan Damjanov): The tumor models described by the two speakers are important for the understanding of cell to cell interactions and for how this interaction can modify the development or reversal of malignancy. In the case of ES cells produced in vitro from explanted embryos the moment of explantation could be considered as initiation. It is arguable whether there is any promotion or progression. It is, however, unquestionable that the embryo derived ES cells have all the features of “immortalized” neoplastic cells, although these characteristics are reversible. I think that is the beauty of this system. Obviously, one cannot monitor all the characteristics of the EC or ES cells, but the message obtained even in a limited experimental system is clear: the genetic determinants of malignancy can be overpowered by the epigenetic control mechanisms. These epigenetic factors may be within the embryo or the culture medium or in the in vivo environment traditionally called the tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Sudilovsky, O., Pitot, H.C., Liotta, L.A. (1991). Summary by Moderator. In: Sudilovsky, O., Pitot, H.C., Liotta, L.A. (eds) Boundaries between Promotion and Progression during Carcinogenesis. Basic Life Sciences, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5994-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5994-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5996-8

  • Online ISBN: 978-1-4684-5994-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics