Abstract
Moderator (Ivan Damjanov): The tumor models described by the two speakers are important for the understanding of cell to cell interactions and for how this interaction can modify the development or reversal of malignancy. In the case of ES cells produced in vitro from explanted embryos the moment of explantation could be considered as initiation. It is arguable whether there is any promotion or progression. It is, however, unquestionable that the embryo derived ES cells have all the features of “immortalized” neoplastic cells, although these characteristics are reversible. I think that is the beauty of this system. Obviously, one cannot monitor all the characteristics of the EC or ES cells, but the message obtained even in a limited experimental system is clear: the genetic determinants of malignancy can be overpowered by the epigenetic control mechanisms. These epigenetic factors may be within the embryo or the culture medium or in the in vivo environment traditionally called the tumor.
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© 1991 Plenum Press, New York
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Sudilovsky, O., Pitot, H.C., Liotta, L.A. (1991). Summary by Moderator. In: Sudilovsky, O., Pitot, H.C., Liotta, L.A. (eds) Boundaries between Promotion and Progression during Carcinogenesis. Basic Life Sciences, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5994-4_9
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DOI: https://doi.org/10.1007/978-1-4684-5994-4_9
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