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Alcohol Abuse and Fuel Homeostasis

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Alcoholism

Part of the book series: NATO ASI Series ((NSSA,volume 206))

Abstract

Ethanol has profound effects on whole-body fuel homeostasis and nutrition: Chronic alcohol abuse is recognised to be the primary cause of malnutrition in developed countries (see Lieber, 1988; World et al., 1985; Morgan and Levine, 1988; Halsted and Keen, 1990; Wheeler, 1990; Halsted, 1991). This is in part because fuel homeostasis in man is dependent on complex inter-organ relationships that govern the supply and utilization of energy substrates. The interaction of ethanol with fuel metabolism in any one specific tissue has the capacity to compromise these inter-organ axes in substrate supply and disposal and to have systemic effects on fuel homeostasis. It is therefore necessary to approach the question of alcohol-related malnutrition and impaired fuel metabolism from the perspective of whole-body fuel homeostasis.

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Authors and Affiliations

  1. Department of Biochemistry, University of Western Australia, Nedlands, Perth, Western Australia, 6009, Australia

    T. Norman Palmer & Paul G. Drake

  2. Department of Clinical Biochemistry, King’s College Hospital School of Medicine and Dentistry, London, UK

    Elisabeth B. Cook

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  1. T. Norman Palmer
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  2. Elisabeth B. Cook
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  3. Paul G. Drake
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  1. The University of Western Australia, Nedlands, Perth, Australia

    T. Norman Palmer

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© 1991 Plenum Press, New York

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Palmer, T.N., Cook, E.B., Drake, P.G. (1991). Alcohol Abuse and Fuel Homeostasis. In: Palmer, T.N. (eds) Alcoholism. NATO ASI Series, vol 206. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5946-3_24

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